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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2005 2
2006 1
2007 2
2008 4
2009 1
2010 3
2011 5
2012 4
2013 10
2014 13
2015 8
2016 11
2017 7
2018 5
2019 10
2020 6
2021 15
2022 11
2023 7
2024 3

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114 results

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Page 1
TMPRSS4: an emerging potential therapeutic target in cancer.
de Aberasturi AL, Calvo A. de Aberasturi AL, et al. Br J Cancer. 2015 Jan 6;112(1):4-8. doi: 10.1038/bjc.2014.403. Epub 2014 Sep 9. Br J Cancer. 2015. PMID: 25203520 Free PMC article. Review.
The transmembrane protease, serine 4 (TMPRSS4) is closely related to other cancer-associated proteases, such as hepsin, TMPRSS2 and matriptase. We review in this study up-to-date information about expression, role, regulation and clinical relevance of TMPRSS4 …
The transmembrane protease, serine 4 (TMPRSS4) is closely related to other cancer-associated proteases, such as hepsin, TMPRSS …
TMPRSS4, a type II transmembrane serine protease, as a potential therapeutic target in cancer.
Kim S. Kim S. Exp Mol Med. 2023 Apr;55(4):716-724. doi: 10.1038/s12276-023-00975-5. Epub 2023 Apr 3. Exp Mol Med. 2023. PMID: 37009799 Free PMC article. Review.
Based on its broad expression profile in cancer, TMPRSS4 has been the focus of attention in anticancer research. This review summarizes up-to-date information regarding the expression, regulation, and clinical relevance of TMPRSS4, as well as its role in path …
Based on its broad expression profile in cancer, TMPRSS4 has been the focus of attention in anticancer research. This review s …
TMPRSS4 promotes cancer stem-like properties in prostate cancer cells through upregulation of SOX2 by SLUG and TWIST1.
Lee Y, Yoon J, Ko D, Yu M, Lee S, Kim S. Lee Y, et al. J Exp Clin Cancer Res. 2021 Nov 22;40(1):372. doi: 10.1186/s13046-021-02147-7. J Exp Clin Cancer Res. 2021. PMID: 34809669 Free PMC article.
BACKGROUND: Transmembrane serine protease 4 (TMPRSS4) is a cell surface-anchored serine protease. Elevated expression of TMPRSS4 correlates with poor prognosis in colorectal cancer, gastric cancer, prostate cancer, non-small cell lung cancer …
BACKGROUND: Transmembrane serine protease 4 (TMPRSS4) is a cell surface-anchored serine protease. Elevated expression of TMPRSS4 …
Role of TMPRSS4 Modulation in Breast Cancer Cell Proliferation.
Assani G, Yessoufou A, Xiong Y, Segbo J, Yu X, Zhou F, Zhou Y. Assani G, et al. Asian Pac J Cancer Prev. 2019 Jun 1;20(6):1849-1856. doi: 10.31557/APJCP.2019.20.6.1849. Asian Pac J Cancer Prev. 2019. PMID: 31244309 Free PMC article.
However, TMPRSS4 functions in breast cancer remain poor understand. The present study investigated the function of TMPRSS4 in the breast cancer cells and the potential mechanistic action underling. ...Conclusion: TMPRSS4 plays important roles in …
However, TMPRSS4 functions in breast cancer remain poor understand. The present study investigated the function of TMPRSS4 …
TMPRSS4 induces cancer cell invasion through pro-uPA processing.
Min HJ, Lee MK, Lee JW, Kim S. Min HJ, et al. Biochem Biophys Res Commun. 2014 Mar 28;446(1):1-7. doi: 10.1016/j.bbrc.2014.01.013. Epub 2014 Jan 14. Biochem Biophys Res Commun. 2014. PMID: 24434139
Previously, we demonstrated that TMPRSS4 mediates cancer cell invasion, epithelial-mesenchymal transition, and metastasis and that increased TMPRSS4 expression correlates with colorectal cancer progression. We also demonstrated that TMPRSS4 upre …
Previously, we demonstrated that TMPRSS4 mediates cancer cell invasion, epithelial-mesenchymal transition, and metastasis and …
Role of TMPRSS4 during cancer progression.
Choi SY, Shin HC, Kim SY, Park YW. Choi SY, et al. Drug News Perspect. 2008 Oct;21(8):417-23. doi: 10.1358/dnp.2008.21.8.1272135. Drug News Perspect. 2008. PMID: 19034347 Free article. Review.
In this review, we describe the characteristics of TTSPs and their role in many human cancers. Among the many TTSPs, we discuss TMPRSS4/MT-SP2 in the greatest detail. ...Regulation of the EMT by proteases such as TMPRSS4 may provide novel therapeutic targets …
In this review, we describe the characteristics of TTSPs and their role in many human cancers. Among the many TTSPs, we discuss TM …
Clinical significance of TMPRSS4 in prostate cancer.
Shi G, Yang X, Dai B, Zhang H, Shen Y, Zhu Y, Zhu Y, Xiao W, Ma C, Wen L, Qin X, Cao D, Ye D. Shi G, et al. Int J Clin Exp Pathol. 2014 Oct 15;7(11):8053-8. eCollection 2014. Int J Clin Exp Pathol. 2014. PMID: 25550850 Free PMC article.
This study aimed to investigate both the expression of TMPRSS4 and its clinical significance in prostate cancer. The expression of TMPRSS4 was evaluated in 73 pairs of prostate cancer and adjacent non-cancerous tissues by immunohistochemistry. T …
This study aimed to investigate both the expression of TMPRSS4 and its clinical significance in prostate cancer. The expressio …
TMPRSS4 promotes invasiveness of human gastric cancer cells through activation of NF-kappaB/MMP-9 signaling.
Jin J, Shen X, Chen L, Bao LW, Zhu LM. Jin J, et al. Biomed Pharmacother. 2016 Feb;77:30-6. doi: 10.1016/j.biopha.2015.11.002. Epub 2015 Dec 11. Biomed Pharmacother. 2016. PMID: 26796262
However, little is known about the biological roles of TMPRSS4 in gastric cancer. In this study, we examined the effect of TMPRSS4 on gastric cancer cell proliferation, migration, and invasion. ...Our study provides the rationale for targeting TMPRS …
However, little is known about the biological roles of TMPRSS4 in gastric cancer. In this study, we examined the effect of …
Prognostic significance of TMPRSS4 in gastric cancer.
Sheng H, Shen W, Zeng J, Xi L, Deng L. Sheng H, et al. Neoplasma. 2014;61(2):213-7. doi: 10.4149/neo_2014_027. Neoplasma. 2014. PMID: 24299317
Transmembrane protease, serine 4 (TMPRSS4), is a novel type of II transmembrane serine protease that is highly expressed in multiple cancers. However the expression pattern and clinical significance of TMPRSS4 in gastric cancer (GC) remain unclear. We …
Transmembrane protease, serine 4 (TMPRSS4), is a novel type of II transmembrane serine protease that is highly expressed in multiple …
Overexpression of TMPRSS4 promotes tumor proliferation and aggressiveness in breast cancer.
Li XM, Liu WL, Chen X, Wang YW, Shi DB, Zhang H, Ma RR, Liu HT, Guo XY, Hou F, Li M, Gao P. Li XM, et al. Int J Mol Med. 2017 Apr;39(4):927-935. doi: 10.3892/ijmm.2017.2893. Epub 2017 Feb 17. Int J Mol Med. 2017. PMID: 28259959 Free PMC article.
Transmembrane protease serine 4 (TMPRSS4) is a novel type II transmembrane serine protease that is overexpressed in various types of human cancers and has an important function in cancer progression. ...To conclude, TMPRSS4 may be a potential therapeut …
Transmembrane protease serine 4 (TMPRSS4) is a novel type II transmembrane serine protease that is overexpressed in various types of …
114 results