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TRAIL sensitivity of nasopharyngeal cancer cells involves redox dependent upregulation of TMTC2 and its interaction with membrane caspase-3.
Raman D, Tay P, Hirpara JL, Liu D, Pervaiz S. Raman D, et al. Redox Biol. 2021 Nov 20;48:102193. doi: 10.1016/j.redox.2021.102193. Online ahead of print. Redox Biol. 2021. PMID: 34839142 Free PMC article.
AIMS: Preferential expression of receptors for TNF-family related apoptosis inducing ligand (TRAIL), DR4 and DR5 makes TRAIL an attractive anti-cancer therapeutic. However, the efficacy of targeting death receptors has not been extensively studied in nasopharyngeal canc …
AIMS: Preferential expression of receptors for TNF-family related apoptosis inducing ligand (TRAIL), DR4 and DR5 makes TRAIL an attractive a …
A novel TMTC2-NTRK3 fusion in undifferentiated high-grade pleomorphic sarcoma.
Bai C, Zhang L, Wang Y, You X, Ju Y, Sun T, Fan Z. Bai C, et al. J Cancer Res Clin Oncol. 2022 Oct;148(10):2933-2937. doi: 10.1007/s00432-022-04249-x. Epub 2022 Aug 7. J Cancer Res Clin Oncol. 2022. PMID: 35933643
Herein, we present a 68-years old man with UHPS by pathological diagnosis. Next-generation sequencing (NGS) revealed a novel TMTC2-NTRK3 fusion, which was also detected by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). ...
Herein, we present a 68-years old man with UHPS by pathological diagnosis. Next-generation sequencing (NGS) revealed a novel TMTC2-NT …
Metastasizing Pleomorphic Adenoma: Recurrent PLAG1/HMGA2 Rearrangements and Identification of a Novel HMGA2-TMTC2 Fusion.
Wasserman JK, Dickson BC, Smith A, Swanson D, Purgina BM, Weinreb I. Wasserman JK, et al. Am J Surg Pathol. 2019 Aug;43(8):1145-1151. doi: 10.1097/PAS.0000000000001280. Am J Surg Pathol. 2019. PMID: 31094927
RNA sequencing performed on the index case demonstrated a novel HMGA2-TMTC2 translocation, which was confirmed by separate FISH break-apart assays for both genes. ...
RNA sequencing performed on the index case demonstrated a novel HMGA2-TMTC2 translocation, which was confirmed by separate FISH break …
Meta-analysis identifies seven susceptibility loci involved in the atopic march.
Marenholz I, Esparza-Gordillo J, Rüschendorf F, Bauerfeind A, Strachan DP, Spycher BD, Baurecht H, Margaritte-Jeannin P, Sääf A, Kerkhof M, Ege M, Baltic S, Matheson MC, Li J, Michel S, Ang WQ, McArdle W, Arnold A, Homuth G, Demenais F, Bouzigon E, Söderhäll C, Pershagen G, de Jongste JC, Postma DS, Braun-Fahrländer C, Horak E, Ogorodova LM, Puzyrev VP, Bragina EY, Hudson TJ, Morin C, Duffy DL, Marks GB, Robertson CF, Montgomery GW, Musk B, Thompson PJ, Martin NG, James A, Sleiman P, Toskala E, Rodriguez E, Fölster-Holst R, Franke A, Lieb W, Gieger C, Heinzmann A, Rietschel E, Keil T, Cichon S, Nöthen MM, Pennell CE, Sly PD, Schmidt CO, Matanovic A, Schneider V, Heinig M, Hübner N, Holt PG, Lau S, Kabesch M, Weidinger S, Hakonarson H, Ferreira MAR, Laprise C, Freidin MB, Genuneit J, Koppelman GH, Melén E, Dizier MH, Henderson AJ, Lee YA. Marenholz I, et al. Nat Commun. 2015 Nov 6;6:8804. doi: 10.1038/ncomms9804. Nat Commun. 2015. PMID: 26542096 Free PMC article.
Here we report two novel loci specific for the combined eczema plus asthma phenotype, which are associated with allergic disease for the first time; rs9357733 located in EFHC1 on chromosome 6p12.3 (OR 1.27; P=2.1 10(-8)) and rs993226 between TMTC2 and SLC6A15 on chromosome …
Here we report two novel loci specific for the combined eczema plus asthma phenotype, which are associated with allergic disease for the fir …