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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1984 1
1988 2
1989 2
1991 5
1993 2
1994 2
1995 5
1996 2
1997 7
1998 5
1999 12
2000 12
2001 9
2002 13
2003 10
2004 18
2005 11
2006 16
2007 15
2008 13
2009 21
2010 29
2011 36
2012 31
2013 22
2014 36
2015 38
2016 28
2017 34
2018 30
2019 52
2020 57
2021 58
2022 57
2023 49
2024 23

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684 results

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Page 1
CECR2 drives breast cancer metastasis by promoting NF-kappaB signaling and macrophage-mediated immune suppression.
Zhang M, Liu ZZ, Aoshima K, Cai WL, Sun H, Xu T, Zhang Y, An Y, Chen JF, Chan LH, Aoshima A, Lang SM, Tang Z, Che X, Li Y, Rutter SJ, Bossuyt V, Chen X, Morrow JS, Pusztai L, Rimm DL, Yin M, Yan Q. Zhang M, et al. Sci Transl Med. 2022 Feb 2;14(630):eabf5473. doi: 10.1126/scitranslmed.abf5473. Epub 2022 Feb 2. Sci Transl Med. 2022. PMID: 35108062 Free PMC article.
Metastasis is the major cause of cancer-related deaths due to the lack of effective therapies. Emerging evidence suggests that certain epigenetic and transcriptional regulators drive cancer metastasis and could be targeted for metastasis treatment. ...Consistent wit …
Metastasis is the major cause of cancer-related deaths due to the lack of effective therapies. Emerging evidence suggests that certai …
Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.
Hoshino A, Kim HS, Bojmar L, Gyan KE, Cioffi M, Hernandez J, Zambirinis CP, Rodrigues G, Molina H, Heissel S, Mark MT, Steiner L, Benito-Martin A, Lucotti S, Di Giannatale A, Offer K, Nakajima M, Williams C, Nogués L, Pelissier Vatter FA, Hashimoto A, Davies AE, Freitas D, Kenific CM, Ararso Y, Buehring W, Lauritzen P, Ogitani Y, Sugiura K, Takahashi N, Alečković M, Bailey KA, Jolissant JS, Wang H, Harris A, Schaeffer LM, García-Santos G, Posner Z, Balachandran VP, Khakoo Y, Raju GP, Scherz A, Sagi I, Scherz-Shouval R, Yarden Y, Oren M, Malladi M, Petriccione M, De Braganca KC, Donzelli M, Fischer C, Vitolano S, Wright GP, Ganshaw L, Marrano M, Ahmed A, DeStefano J, Danzer E, Roehrl MHA, Lacayo NJ, Vincent TC, Weiser MR, Brady MS, Meyers PA, Wexler LH, Ambati SR, Chou AJ, Slotkin EK, Modak S, Roberts SS, Basu EM, Diolaiti D, Krantz BA, Cardoso F, Simpson AL, Berger M, Rudin CM, Simeone DM, Jain M, Ghajar CM, Batra SK, Stanger BZ, Bui J, Brown KA, Rajasekhar VK, Healey JH, de Sousa M, Kramer K, Sheth S, Baisch J, Pascual V, Heaton TE, La Quaglia MP, Pisapia DJ, Schwartz R, Zhang H, Liu Y, Shukla A, Blavier L, DeClerck YA, LaBarge M, Bissell MJ, Caffrey TC, Grandgenett PM, Hollingsw… See abstract for full author list ➔ Hoshino A, et al. Cell. 2020 Aug 20;182(4):1044-1061.e18. doi: 10.1016/j.cell.2020.07.009. Epub 2020 Aug 13. Cell. 2020. PMID: 32795414 Free PMC article.
There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection. We investigated the proteomic profile of extracellular vesicles and particles (EVPs) in 426 human samples from tissue explants (TEs), plasma, and other bodily fluids. ...Thus, …
There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection. We investigated the proteomic profi …
Genomic heterogeneity as a barrier to precision oncology in urothelial cancer.
Clinton TN, Chen Z, Wise H, Lenis AT, Chavan S, Donoghue MTA, Almassi N, Chu CE, Dason S, Rao P, Rodrigues JA, Vasani NB, Ridouani F, Rosenberg JE, Bajorin DF, Teo MY, Bochner BH, Berger MF, Ostrovnaya I, Pietzak EJ, Iyer G, Gao SP, Hu W, Al-Ahmadie HA, Solit DB. Clinton TN, et al. Cell Rep. 2022 Dec 20;41(12):111859. doi: 10.1016/j.celrep.2022.111859. Cell Rep. 2022. PMID: 36543146 Free PMC article.
Precision oncology relies on the accurate molecular characterization of individual patients with cancer at the time of treatment initiation. However, tumor molecular profiles are not static, and cancers continually evolve because of ongoing mutagenesis and clonal se …
Precision oncology relies on the accurate molecular characterization of individual patients with cancer at the time of treatment init …
Effect of activating cancer-associated fibroblasts biomarker TNC on immune cell infiltration and prognosis in breast cancer.
Huang T, Lu C, Zhang Y, Lin BY, Zhang ZJ, Zhu D, Wang L, Lu Y. Huang T, et al. Ann Med. 2023;55(2):2250987. doi: 10.1080/07853890.2023.2250987. Epub 2023 Nov 6. Ann Med. 2023. PMID: 38375814 Free PMC article.
Immunohistochemical (IHC) staining was used to determine the expression levels of TNC in 160 breast cancer samples pathologically diagnosed as invasive ductal carcinoma that were not otherwise specified (IDC-NOS). ...Fibroblasts in breast cancer are activated …
Immunohistochemical (IHC) staining was used to determine the expression levels of TNC in 160 breast cancer samples pathologica …
Tenascin-C and integrins in cancer.
Yoshida T, Akatsuka T, Imanaka-Yoshida K. Yoshida T, et al. Cell Adh Migr. 2015;9(1-2):96-104. doi: 10.1080/19336918.2015.1008332. Cell Adh Migr. 2015. PMID: 25793576 Free PMC article. Review.
Tenascin-C (TNC) is highly expressed in cancer tissues. Its cellular sources are cancer and stromal cells, including fibroblasts/myofibroblasts, and also vascular cells. TNC expressed in cancer tissues dominantly contains large splice variants. …
Tenascin-C (TNC) is highly expressed in cancer tissues. Its cellular sources are cancer and stromal cells, including fi …
Tumor-derived Cav-1 promotes pre-metastatic niche formation and lung metastasis in breast cancer.
Wang Y, Li Y, Zhong J, Li M, Zhou Y, Lin Q, Zong S, Luo W, Wang J, Wang K, Wang J, Xiong L. Wang Y, et al. Theranostics. 2023 Mar 13;13(5):1684-1697. doi: 10.7150/thno.79250. eCollection 2023. Theranostics. 2023. PMID: 37056561 Free PMC article.
Rationale: Breast cancer (BC), as one of the most frequently diagnosed cancer, has a poor prognosis due to the development of distant metastasis. ...Although studies have revealed that Cav-1 levels were elevated in patients with advanced cancer, whether Cav-1 …
Rationale: Breast cancer (BC), as one of the most frequently diagnosed cancer, has a poor prognosis due to the development of …
Advances on the roles of tenascin-C in cancer.
Yilmaz A, Loustau T, Salomé N, Poilil Surendran S, Li C, Tucker RP, Izzi V, Lamba R, Koch M, Orend G. Yilmaz A, et al. J Cell Sci. 2022 Sep 15;135(18):jcs260244. doi: 10.1242/jcs.260244. Epub 2022 Sep 14. J Cell Sci. 2022. PMID: 36102918 Free PMC article.
This supports potential roles for TNC in immunity control. Advances using murine models with engineered TNC levels were instrumental in the discovery of important functions of TNC as a danger-associated molecular pattern (DAMP) molecule in tissue repair and r …
This supports potential roles for TNC in immunity control. Advances using murine models with engineered TNC levels were instru …
Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs.
Hongu T, Pein M, Insua-Rodríguez J, Gutjahr E, Mattavelli G, Meier J, Decker K, Descot A, Bozza M, Harbottle R, Trumpp A, Sinn HP, Riedel A, Oskarsson T. Hongu T, et al. Nat Cancer. 2022 Apr;3(4):486-504. doi: 10.1038/s43018-022-00353-6. Epub 2022 Apr 25. Nat Cancer. 2022. PMID: 35469015 Free PMC article.
Disseminated cancer cells frequently lodge near vasculature in secondary organs. ...Here, we identify intercellular machinery governing formation of a pro-metastatic vascular niche during breast cancer colonization in the lung. We show that specific secreted factors …
Disseminated cancer cells frequently lodge near vasculature in secondary organs. ...Here, we identify intercellular machinery governi …
CircIPO7 Promotes Nasopharyngeal Carcinoma Metastasis and Cisplatin Chemoresistance by Facilitating YBX1 Nuclear Localization.
Hong X, Li Q, Li J, Chen K, He Q, Zhao Y, Liang Y, Zhao Y, Qiao H, Liu N, Ma J, Li Y. Hong X, et al. Clin Cancer Res. 2022 Oct 14;28(20):4521-4535. doi: 10.1158/1078-0432.CCR-22-0991. Clin Cancer Res. 2022. PMID: 35917517
Mechanistically, circIPO7 binds to Y-box binding protein-1 (YBX1) protein in the cytoplasm and facilitates its phosphorylation at serine 102 (p-YBX1S102) by the kinase AKT, which further promotes YBX1 nuclear translocation and activates FGFR1, TNC, and NTRK1 transcription. …
Mechanistically, circIPO7 binds to Y-box binding protein-1 (YBX1) protein in the cytoplasm and facilitates its phosphorylation at serine 102 …
Inaugurating High-Throughput Profiling of Extracellular Vesicles for Earlier Ovarian Cancer Detection.
Jo A, Green A, Medina JE, Iyer S, Ohman AW, McCarthy ET, Reinhardt F, Gerton T, Demehin D, Mishra R, Kolin DL, Zheng H, Cheon J, Crum CP, Weinberg RA, Rueda BR, Castro CM, Dinulescu DM, Lee H. Jo A, et al. Adv Sci (Weinh). 2023 Sep;10(27):e2301930. doi: 10.1002/advs.202301930. Epub 2023 Jul 23. Adv Sci (Weinh). 2023. PMID: 37485618 Free PMC article.
In serially-drawn blood of tumor-bearing mice, mFT-EV markers increase with tumor initiation, supporting their potential use in early cancer detection. A pilot clinical study (n = 51) further narrows EV markers to five candidates, EpCAM, CD24, VCAN, HE4, and TNC. Th …
In serially-drawn blood of tumor-bearing mice, mFT-EV markers increase with tumor initiation, supporting their potential use in early can …
684 results