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TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons.
Zhao S, Lu J, Pan B, Fan H, Byrum SD, Xu C, Kim A, Guo Y, Kanchi KL, Gong W, Sun T, Storey AJ, Burkholder NT, Mackintosh SG, Kuhlers PC, Edmondson RD, Strahl BD, Diao Y, Tackett AJ, Raab JR, Cai L, Song J, Wang GG. Zhao S, et al. Nature. 2023 Nov;623(7987):633-642. doi: 10.1038/s41586-023-06688-z. Epub 2023 Nov 8. Nature. 2023. PMID: 37938770 Free PMC article.
Biochemical, biophysical and structural studies identified the carboxy-terminal bromo-adjacent homology (BAH) domain of TNRC18 (TNRC18(BAH)) as an H3K9me3-specific reader. Moreover, the amino-terminal segment of TNRC18 is a platform for the direct recruitment …
Biochemical, biophysical and structural studies identified the carboxy-terminal bromo-adjacent homology (BAH) domain of TNRC18 (TN …
Molecular subtype classification of papillary renal cell cancer using miRNA expression.
Yu C, Dai D, Xie J. Yu C, et al. Onco Targets Ther. 2019 Mar 29;12:2311-2322. doi: 10.2147/OTT.S193808. eCollection 2019. Onco Targets Ther. 2019. PMID: 31015763 Free PMC article.
In the differential molecular subtypes, we performed an integrated analysis of survival, DE genes, biological function and somatic mutations on the cohort of KIRP patients from The Cancer Genome Atlas. RESULTS: From solutions with 2, 3, 4, 5, 6 and 7 clusters we selected t …
In the differential molecular subtypes, we performed an integrated analysis of survival, DE genes, biological function and somatic mutations …
Identification of a novel TNRC18-RARA fusion in acute promyelocytic leukemia lacking t(15;17)(q24;q12)/PML-RARA.
Wang Z, Wen L, Zhang L, Xu X, Chen X, Yao L, Wang M, Shen Z, Mo G, Wang Y, Zhao D, Cai W, Shen J, Chi X, Xu Y, Zeng Z, Pan J, Ruan C, Wu D, Jia Z, Chen S. Wang Z, et al. Mol Carcinog. 2021 Feb;60(2). doi: 10.1002/mc.23276. Epub 2021 Jan 11. Mol Carcinog. 2021. PMID: 33428799
Acute promyelocytic leukemia (APL) is a unique disease entity in acute myeloid leukemia, characterized by PML-RARA fusion gene, which is generated by chromosomal translocation t(15;17)(q24;q21). We identified TNRC18-RARA as novel RARA fusion in resembling APL. Our study hi …
Acute promyelocytic leukemia (APL) is a unique disease entity in acute myeloid leukemia, characterized by PML-RARA fusion gene, which is gen …
Venetoclax overcomes resistance to all-trans retinoic acid in a variant acute promyelocytic leukemia with TNRC18::RARA fusion.
Xu J, Li H, Wang Z, Wang M, Li Q, Hang X, Xu J, Ji J, Chen C, Liu Y, Niu T. Xu J, et al. Mol Carcinog. 2024 Apr;63(4):553-557. doi: 10.1002/mc.23671. Epub 2023 Dec 22. Mol Carcinog. 2024. PMID: 38131515
Acute promyelocytic leukemia (APL) is generally driven by PML::RARA, but approximately 2% of variant APL patients do not contain this fusion gene and pose challenges in diagnosis and treatment. Here, we reported an aggressive APL patient with variant TNRC18::RARA fusion ge …
Acute promyelocytic leukemia (APL) is generally driven by PML::RARA, but approximately 2% of variant APL patients do not contain this fusion …
Distinct genomic landscape of Chinese pediatric acute myeloid leukemia impacts clinical risk classification.
Liu T, Rao J, Hu W, Cui B, Cai J, Liu Y, Sun H, Chen X, Tang Y, Chen J, Wang X, Wang H, Qian W, Mao B, Guo S, Wang R, Liu Y, Shen S. Liu T, et al. Nat Commun. 2022 Mar 28;13(1):1640. doi: 10.1038/s41467-022-29336-y. Nat Commun. 2022. PMID: 35347147 Free PMC article.
Here we present the genomic landscape of driver alterations of Chinese pediatric AML and discover previously undescribed genomic aberrations, including the XPO1-TNRC18 fusion. Comprehensively comparing between the Chinese and Western AML cohorts reveal a substantially dist …
Here we present the genomic landscape of driver alterations of Chinese pediatric AML and discover previously undescribed genomic aberrations …