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Mutational processes shape the landscape of TP53 mutations in human cancer.
Giacomelli AO, Yang X, Lintner RE, McFarland JM, Duby M, Kim J, Howard TP, Takeda DY, Ly SH, Kim E, Gannon HS, Hurhula B, Sharpe T, Goodale A, Fritchman B, Steelman S, Vazquez F, Tsherniak A, Aguirre AJ, Doench JG, Piccioni F, Roberts CWM, Meyerson M, Getz G, Johannessen CM, Root DE, Hahn WC. Giacomelli AO, et al. Nat Genet. 2018 Oct;50(10):1381-1387. doi: 10.1038/s41588-018-0204-y. Epub 2018 Sep 17. Nat Genet. 2018. PMID: 30224644 Free PMC article.
Unlike most tumor suppressor genes, the most common genetic alterations in tumor protein p53 (TP53) are missense mutations(1,2). Mutant p53 protein is often abundantly expressed in cancers and specific allelic variants exhibit dominant-negative or gain-of-function a …
Unlike most tumor suppressor genes, the most common genetic alterations in tumor protein p53 (TP53) are missense mutations(1,2). Muta …
Should mutant TP53 be targeted for cancer therapy?
Wang Z, Strasser A, Kelly GL. Wang Z, et al. Cell Death Differ. 2022 May;29(5):911-920. doi: 10.1038/s41418-022-00962-9. Epub 2022 Mar 24. Cell Death Differ. 2022. PMID: 35332311 Free PMC article. Review.
Mutations in the TP53 tumour suppressor gene are found in ~50% of human cancers [1-6]. ...Most mutations in TP53 in human cancers cause a single amino acid substitution, usually within the DNA binding domain of the TP53 protein. ...
Mutations in the TP53 tumour suppressor gene are found in ~50% of human cancers [1-6]. ...Most mutations in TP53 in hum …
TP53 mutations in nonsmall cell lung cancer.
Mogi A, Kuwano H. Mogi A, et al. J Biomed Biotechnol. 2011;2011:583929. doi: 10.1155/2011/583929. Epub 2011 Jan 18. J Biomed Biotechnol. 2011. PMID: 21331359 Free PMC article. Review.
The tumor suppressor gene TP53 is frequently mutated in human cancers. Abnormality of the TP53 gene is one of the most significant events in lung cancers and plays an important role in the tumorigenesis of lung epithelial cells. Human lung cancers …
The tumor suppressor gene TP53 is frequently mutated in human cancers. Abnormality of the TP53 gene is one of the most …
Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas.
Donehower LA, Soussi T, Korkut A, Liu Y, Schultz A, Cardenas M, Li X, Babur O, Hsu TK, Lichtarge O, Weinstein JN, Akbani R, Wheeler DA. Donehower LA, et al. Cell Rep. 2019 Jul 30;28(5):1370-1384.e5. doi: 10.1016/j.celrep.2019.07.001. Cell Rep. 2019. PMID: 31365877 Free PMC article.
The TP53 tumor suppressor gene is frequently mutated in human cancers. ...A mutant TP53 RNA expression signature shows significant correlation with reduced survival in 11 cancer types. ...
The TP53 tumor suppressor gene is frequently mutated in human cancers. ...A mutant TP53 RNA expression signature shows …
TP53 mutations in human cancers: origins, consequences, and clinical use.
Olivier M, Hollstein M, Hainaut P. Olivier M, et al. Cold Spring Harb Perspect Biol. 2010 Jan;2(1):a001008. doi: 10.1101/cshperspect.a001008. Cold Spring Harb Perspect Biol. 2010. PMID: 20182602 Free PMC article. Review.
Somatic mutations in the TP53 gene are one of the most frequent alterations in human cancers, and germline mutations are the underlying cause of Li-Fraumeni syndrome, which predisposes to a wide spectrum of early-onset cancers. ...All mutations found in human …
Somatic mutations in the TP53 gene are one of the most frequent alterations in human cancers, and germline mutations are the u …
Germline TP53 pathogenic variants and breast cancer: A narrative review.
Blondeaux E, Arecco L, Punie K, Graffeo R, Toss A, De Angelis C, Trevisan L, Buzzatti G, Linn SC, Dubsky P, Cruellas M, Partridge AH, Balmaña J, Paluch-Shimon S, Lambertini M. Blondeaux E, et al. Cancer Treat Rev. 2023 Mar;114:102522. doi: 10.1016/j.ctrv.2023.102522. Epub 2023 Jan 31. Cancer Treat Rev. 2023. PMID: 36739824 Free article. Review.
Multiple breast cancer predisposing genes, including TP53, are responsible for the increased breast cancer risk. ...Some studies suggest that patients with breast cancer and germline TP53 PV might have worse survival outcomes compared to patient …
Multiple breast cancer predisposing genes, including TP53, are responsible for the increased breast cancer risk. ...Som …
Convergent TP53 loss and evolvability in cancer.
Mansur MB, Greaves M. Mansur MB, et al. BMC Ecol Evol. 2023 Sep 25;23(1):54. doi: 10.1186/s12862-023-02146-6. BMC Ecol Evol. 2023. PMID: 37743495 Free PMC article. Review.
Genomic scrutiny of patient samples reveals an extraordinary diversity of mutational profiles both between patients with similar cancers and within the cancer cell population of individual patients. ...Major evolutionary innovations or adaptations in different speci …
Genomic scrutiny of patient samples reveals an extraordinary diversity of mutational profiles both between patients with similar cancers …
Cancer incidence, patterns, and genotype-phenotype associations in individuals with pathogenic or likely pathogenic germline TP53 variants: an observational cohort study.
de Andrade KC, Khincha PP, Hatton JN, Frone MN, Wegman-Ostrosky T, Mai PL, Best AF, Savage SA. de Andrade KC, et al. Lancet Oncol. 2021 Dec;22(12):1787-1798. doi: 10.1016/S1470-2045(21)00580-5. Epub 2021 Nov 12. Lancet Oncol. 2021. PMID: 34780712 Free PMC article.
We aimed to characterise and quantify cancer incidence, patterns, and genotype-phenotype associations in individuals with pathogenic or likely pathogenic germline TP53 variants. ...Multiple cancers were diagnosed within a short timeframe in some individuals, …
We aimed to characterise and quantify cancer incidence, patterns, and genotype-phenotype associations in individuals with pathogenic …
The Role of TP53 in Adaptation and Evolution.
Voskarides K, Giannopoulou N. Voskarides K, et al. Cells. 2023 Feb 3;12(3):512. doi: 10.3390/cells12030512. Cells. 2023. PMID: 36766853 Free PMC article. Review.
The TP53 gene is a major player in cancer formation, and it is considered the most important tumor suppressor gene. ...It is not clear why these driver mutations do not transform these tissues into cancerous ones. Other studies have shown that elephants have …
The TP53 gene is a major player in cancer formation, and it is considered the most important tumor suppressor gene. ...It is n …
p53, cancer and the immune response.
Blagih J, Buck MD, Vousden KH. Blagih J, et al. J Cell Sci. 2020 Mar 6;133(5):jcs237453. doi: 10.1242/jcs.237453. J Cell Sci. 2020. PMID: 32144194 Review.
The importance of cancer-cell-autonomous functions of the tumour suppressor p53 (encoded by TP53) has been established in many studies, but it is now clear that the p53 status of the cancer cell also has a profound impact on the immune response. Loss or mutat …
The importance of cancer-cell-autonomous functions of the tumour suppressor p53 (encoded by TP53) has been established in many …
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