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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1997 1
1999 2
2000 3
2001 3
2002 5
2003 6
2004 7
2005 12
2006 9
2007 20
2008 12
2009 20
2010 32
2011 39
2012 40
2013 41
2014 45
2015 62
2016 45
2017 39
2018 45
2019 47
2020 52
2021 41
2022 17
2023 11
2024 9

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602 results

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Page 1
Association between the TP53BP1 rs2602141 A/C polymorphism and cancer risk: a systematic review and meta-analysis.
Liu L, Zhang D, Jiao JH, Wang Y, Wu JY, Huang DS. Liu L, et al. Asian Pac J Cancer Prev. 2014;15(6):2917-22. doi: 10.7314/apjcp.2014.15.6.2917. Asian Pac J Cancer Prev. 2014. PMID: 24761925 Free article. Review.
BACKGROUND: The p53-binding protein 1 (TP53BP1) gene may be involved in the development of cancer through disrupting DNA repair. However, investigation of associations between TP53BP1 rs2602141 A/C polymorphism and cancer have yielded contradictory and …
BACKGROUND: The p53-binding protein 1 (TP53BP1) gene may be involved in the development of cancer through disrupting DNA repai …
Lack of association of the TP53BP1 Glu353Asp polymorphism with risk of cancer: a systematic review and meta-analysis.
Liu L, Jiao J, Wang Y, Zhang D, Wu J, Huang D. Liu L, et al. PLoS One. 2014 Mar 6;9(3):e90931. doi: 10.1371/journal.pone.0090931. eCollection 2014. PLoS One. 2014. PMID: 24603722 Free PMC article. Review.
OBJECTIVE: The TP53BP1 gene may be involved in the development of cancer through disrupting DNA repair. ...The results indicated that the Glu353Asp (rs560191) polymorphism in TP53BP1 gene had no association with cancer risk for all genetic models. ...
OBJECTIVE: The TP53BP1 gene may be involved in the development of cancer through disrupting DNA repair. ...The results indicat …
The antitumorigenic roles of BRCA1-BARD1 in DNA repair and replication.
Tarsounas M, Sung P. Tarsounas M, et al. Nat Rev Mol Cell Biol. 2020 May;21(5):284-299. doi: 10.1038/s41580-020-0218-z. Epub 2020 Feb 24. Nat Rev Mol Cell Biol. 2020. PMID: 32094664 Free PMC article. Review.
The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA double-strand break (DSB) repair by homologous recombination and protects DNA replication forks from attrition. ...Understanding the functional crosstalk between BRCA1-BARD1 and its cofa …
The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA double-strand break (DSB) repair by homologous …
Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.
Hu Q, Botuyan MV, Zhao D, Cui G, Mer E, Mer G. Hu Q, et al. Nature. 2021 Aug;596(7872):438-443. doi: 10.1038/s41586-021-03716-8. Epub 2021 Jul 28. Nature. 2021. PMID: 34321665 Free PMC article.
These data provide a structural framework to evaluate BARD1 variants and help to identify mutations that drive the development of cancer....
These data provide a structural framework to evaluate BARD1 variants and help to identify mutations that drive the development of cancer …
RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer.
Cruz C, Castroviejo-Bermejo M, Gutiérrez-Enríquez S, Llop-Guevara A, Ibrahim YH, Gris-Oliver A, Bonache S, Morancho B, Bruna A, Rueda OM, Lai Z, Polanska UM, Jones GN, Kristel P, de Bustos L, Guzman M, Rodríguez O, Grueso J, Montalban G, Caratú G, Mancuso F, Fasani R, Jiménez J, Howat WJ, Dougherty B, Vivancos A, Nuciforo P, Serres-Créixams X, Rubio IT, Oaknin A, Cadogan E, Barrett JC, Caldas C, Baselga J, Saura C, Cortés J, Arribas J, Jonkers J, Díez O, O'Connor MJ, Balmaña J, Serra V. Cruz C, et al. Ann Oncol. 2018 May 1;29(5):1203-1210. doi: 10.1093/annonc/mdy099. Ann Oncol. 2018. PMID: 29635390 Free PMC article.
Their efficacy in germline BRCA1/2 (gBRCA1/2)-mutated metastatic breast cancers has been recently confirmed in clinical trials. Numerous mechanisms of PARPi resistance have been described, whose clinical relevance in gBRCA-mutated breast cancer is unknown. ...In PAR …
Their efficacy in germline BRCA1/2 (gBRCA1/2)-mutated metastatic breast cancers has been recently confirmed in clinical trials. Numer …
Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance.
Zatreanu D, Robinson HMR, Alkhatib O, Boursier M, Finch H, Geo L, Grande D, Grinkevich V, Heald RA, Langdon S, Majithiya J, McWhirter C, Martin NMB, Moore S, Neves J, Rajendra E, Ranzani M, Schaedler T, Stockley M, Wiggins K, Brough R, Sridhar S, Gulati A, Shao N, Badder LM, Novo D, Knight EG, Marlow R, Haider S, Callen E, Hewitt G, Schimmel J, Prevo R, Alli C, Ferdinand A, Bell C, Blencowe P, Bot C, Calder M, Charles M, Curry J, Ekwuru T, Ewings K, Krajewski W, MacDonald E, McCarron H, Pang L, Pedder C, Rigoreau L, Swarbrick M, Wheatley E, Willis S, Wong AC, Nussenzweig A, Tijsterman M, Tutt A, Boulton SJ, Higgins GS, Pettitt SJ, Smith GCM, Lord CJ. Zatreanu D, et al. Nat Commun. 2021 Jun 17;12(1):3636. doi: 10.1038/s41467-021-23463-8. Nat Commun. 2021. PMID: 34140467 Free PMC article.
To identify approaches to target DNA repair vulnerabilities in cancer, we discovered nanomolar potent, selective, low molecular weight (MW), allosteric inhibitors of the polymerase function of DNA polymerase Polteta, including ART558. ...
To identify approaches to target DNA repair vulnerabilities in cancer, we discovered nanomolar potent, selective, low molecular weigh …
Cancer-specific gene therapy.
Lo HW, Day CP, Hung MC. Lo HW, et al. Adv Genet. 2005;54:235-55. doi: 10.1016/S0065-2660(05)54010-0. Adv Genet. 2005. PMID: 16096014 Review.
Cancer cells transcriptionally activate many genes that are important for uncontrolled proliferation and cell death. ...Additionally, tumor-specific translation of tumor-killing genes has been also exploited in cancer gene therapy. Based on these rationales, canc …
Cancer cells transcriptionally activate many genes that are important for uncontrolled proliferation and cell death. ...Additionally, …
Functional interrogation of DNA damage response variants with base editing screens.
Cuella-Martin R, Hayward SB, Fan X, Chen X, Huang JW, Taglialatela A, Leuzzi G, Zhao J, Rabadan R, Lu C, Shen Y, Ciccia A. Cuella-Martin R, et al. Cell. 2021 Feb 18;184(4):1081-1097.e19. doi: 10.1016/j.cell.2021.01.041. Cell. 2021. PMID: 33606978 Free PMC article.
Mutations in DNA damage response (DDR) genes endanger genome integrity and predispose to cancer and genetic disorders. Here, using CRISPR-dependent cytosine base editing screens, we identify > 2,000 sgRNAs that generate nucleotide variants in 86 DDR genes, resulting in …
Mutations in DNA damage response (DDR) genes endanger genome integrity and predispose to cancer and genetic disorders. Here, using CR …
Cigarette smoking, TP53 Arg72Pro, TP53BP1 Asp353Glu and the risk of lung cancer in a Japanese population.
Kiyohara C, Horiuchi T, Miyake Y, Takayama K, Nakanishi Y. Kiyohara C, et al. Oncol Rep. 2010 May;23(5):1361-8. doi: 10.3892/or_00000772. Oncol Rep. 2010. PMID: 20372852
DNA damage-dependent interaction between TP53 and TP53BP1 may contribute to lung cancer risk. We aimed to assess whether or not TP53 and TP53BP1 genetic polymorphisms modulate lung cancer susceptibility in a Japanese population. We investigated the rel …
DNA damage-dependent interaction between TP53 and TP53BP1 may contribute to lung cancer risk. We aimed to assess whether or no …
DNA repair genes PAXIP1 and TP53BP1 expression is associated with breast cancer prognosis.
De Gregoriis G, Ramos JA, Fernandes PV, Vignal GM, Brianese RC, Carraro DM, Monteiro AN, Struchiner CJ, Suarez-Kurtz G, Vianna-Jorge R, de Carvalho MA. De Gregoriis G, et al. Cancer Biol Ther. 2017 Jun 3;18(6):439-449. doi: 10.1080/15384047.2017.1323590. Epub 2017 May 5. Cancer Biol Ther. 2017. PMID: 28475402 Free PMC article.
We investigated the expression profile of 7 tBRCT genes (BARD1, BRCA1, LIG4, ECT2, MDC1, PAXIP1/PTIP and TP53BP1) in breast cancer specimens and observed a high correlation between PAXIP1 and TP53BP1 gene expression in tumor samples. ...Taken together our fin …
We investigated the expression profile of 7 tBRCT genes (BARD1, BRCA1, LIG4, ECT2, MDC1, PAXIP1/PTIP and TP53BP1) in breast cancer …
602 results