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1995 1
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279 results

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Page 1
N(6)-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma.
Chen Y, Lu Z, Qi C, Yu C, Li Y, Huan W, Wang R, Luo W, Shen D, Ding L, Ren L, Xie H, Xue D, Wang M, Ni K, Xia L, Qian J, Li G. Chen Y, et al. Mol Cancer. 2022 May 10;21(1):111. doi: 10.1186/s12943-022-01549-1. Mol Cancer. 2022. PMID: 35538475 Free PMC article.
Silencing TRAF1 increased sunitinib-induced apoptotic and antiangiogenic effects. Mechanistically, the upregulated level of TRAF1 in sunitinib-resistant cells was derived from increased TRAF1 RNA stability, which was caused by an increased level of N6-methyla …
Silencing TRAF1 increased sunitinib-induced apoptotic and antiangiogenic effects. Mechanistically, the upregulated level of TRAF1 …
TRAF1 Signaling in Human Health and Disease.
Edilova MI, Abdul-Sater AA, Watts TH. Edilova MI, et al. Front Immunol. 2018 Dec 18;9:2969. doi: 10.3389/fimmu.2018.02969. eCollection 2018. Front Immunol. 2018. PMID: 30619326 Free PMC article. Review.
TRAF1 has diverse roles in human disease. TRAF1 is overexpressed in many B cell related cancers and single nucleotide polymorphisms (SNPs) in TRAF1 have been linked to non-Hodgkin's lymphoma. ...Then we discuss the role of TRAF1 in human disease …
TRAF1 has diverse roles in human disease. TRAF1 is overexpressed in many B cell related cancers and single nucleotide p …
[Construction of RNAi targeting TRAF1 gene and effect of TRAF1 on gastric cancer cells].
Wang F, Yang Y, Feng Q, Bu G, Huang L, Lu H, Guo Q, Xu C, Shen S. Wang F, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012 Sep;37(9):876-82. doi: 10.3969/j.issn.1672-7347.2012.09.003. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012. PMID: 23000760 Chinese.
METHODS: We detected the expression of TRAF1 in BGC823, SGC7901, and MGC803 gastric cancer cell lines through the real-time PCR and Western blot; then we constructed three pLVXshRNA- TRAF1-shRNAs expression vector targeting TRAF1. ...The interference t …
METHODS: We detected the expression of TRAF1 in BGC823, SGC7901, and MGC803 gastric cancer cell lines through the real-time PC …
TRAP1 Chaperones the Metabolic Switch in Cancer.
Wengert LA, Backe SJ, Bourboulia D, Mollapour M, Woodford MR. Wengert LA, et al. Biomolecules. 2022 Jun 4;12(6):786. doi: 10.3390/biom12060786. Biomolecules. 2022. PMID: 35740911 Free PMC article. Review.
TRAP1 attenuation induces apoptosis in cellular models of cancer, identifying TRAP1 as a potential therapeutic target in cancer. ...Here, we will discuss the consequence of TRAP1 deregulation in cancer and the impact of post-translational modification on the …
TRAP1 attenuation induces apoptosis in cellular models of cancer, identifying TRAP1 as a potential therapeutic target in cancer …
TRAF1 Is Critical for Regulating the BRAF/MEK/ERK Pathway in Non-Small Cell Lung Carcinogenesis.
Wang Q, Gao G, Zhang T, Yao K, Chen H, Park MH, Yamamoto H, Wang K, Ma W, Malakhova M, Bode AM, Dong Z. Wang Q, et al. Cancer Res. 2018 Jul 15;78(14):3982-3994. doi: 10.1158/0008-5472.CAN-18-0429. Epub 2018 May 10. Cancer Res. 2018. PMID: 29748372 Free PMC article.
However, the role of TRAF1 in non-small cell lung cancer (NSCLC) remains unknown. In this study, we report that TRAF1 is overexpressed in human lung cancer cells and tissues. ...Overall, our work suggests that TRAF1 plays a novel role in the reg …
However, the role of TRAF1 in non-small cell lung cancer (NSCLC) remains unknown. In this study, we report that TRAF1 i …
Mir-483 inhibits colon cancer cell proliferation and migration by targeting TRAF1.
Niu ZY, Li WL, Jiang DL, Li YS, Xie XJ. Niu ZY, et al. Kaohsiung J Med Sci. 2018 Sep;34(9):479-486. doi: 10.1016/j.kjms.2018.04.005. Epub 2018 May 24. Kaohsiung J Med Sci. 2018. PMID: 30173777 Free article.
The target gene of miR-483 was predicted by target scan software and identified by a dual fluorescence reporter system which showed that TRAF1 was a direct target gene of miR-483 in SW480 cell line. These data suggest that miR-483 is a colorectal cancer suppressor w …
The target gene of miR-483 was predicted by target scan software and identified by a dual fluorescence reporter system which showed that …
TRAF1 Is Critical for DMBA/Solar UVR-Induced Skin Carcinogenesis.
Yamamoto H, Ryu J, Min E, Oi N, Bai R, Zykova TA, Yu DH, Moriyama K, Bode AM, Dong Z. Yamamoto H, et al. J Invest Dermatol. 2017 Jun;137(6):1322-1332. doi: 10.1016/j.jid.2016.12.026. Epub 2017 Jan 25. J Invest Dermatol. 2017. PMID: 28131816 Free PMC article.
Although aberrant TRAF1 expression in tumors has been reported, the role of TRAF1 remains elusive. ...Targeting TRAF1 function might lead to strategies for preventing and treating skin cancer....
Although aberrant TRAF1 expression in tumors has been reported, the role of TRAF1 remains elusive. ...Targeting TRAF1 f …
Colorectal Cancer-Associated Immune Exhaustion Involves T and B Lymphocytes and Conventional NK Cells and Correlates With a Shorter Overall Survival.
Sorrentino C, D'Antonio L, Fieni C, Ciummo SL, Di Carlo E. Sorrentino C, et al. Front Immunol. 2021 Dec 16;12:778329. doi: 10.3389/fimmu.2021.778329. eCollection 2021. Front Immunol. 2021. PMID: 34975867 Free PMC article.
Colorectal cancer (CRC) is one of the most common cancer worldwide, with a growing impact on public health and clinical management. Immunotherapy has shown promise in the treatment of advanced cancers, but needs to be improved for CRC, since only a limited fr …
Colorectal cancer (CRC) is one of the most common cancer worldwide, with a growing impact on public health and clinical manage …
The relationship between TRAF6 and tumors.
Li J, Liu N, Tang L, Yan B, Chen X, Zhang J, Peng C. Li J, et al. Cancer Cell Int. 2020 Sep 3;20:429. doi: 10.1186/s12935-020-01517-z. eCollection 2020. Cancer Cell Int. 2020. PMID: 32905356 Free PMC article. Review.
Tumor necrosis factor receptor (TNFR)-related factors (TRAFs) are important linker molecules in the tumor necrosis factor superfamily (TNFSF) and the Toll-like/interleukin-1 receptor (TLR/ILR) superfamily. There are seven members: TRAF1-TRAF7, among those members, tumor ne …
Tumor necrosis factor receptor (TNFR)-related factors (TRAFs) are important linker molecules in the tumor necrosis factor superfamily (TNFSF …
TNFR2/BIRC3-TRAF1 signaling pathway as a novel NK cell immune checkpoint in cancer.
Ivagnès A, Messaoudene M, Stoll G, Routy B, Fluckiger A, Yamazaki T, Iribarren K, Duong CPM, Fend L, Caignard A, Cremer I, LeCesne A, Adam J, Honoré C, Mir O, Chaigneau L, Berger A, Validire P, Christidis C, Brun-Ly VL, Smyth MJ, Mariette X, Salomon BL, Kroemer G, Rusakiewicz S, Zitvogel L. Ivagnès A, et al. Oncoimmunology. 2017 Oct 11;7(12):e1386826. doi: 10.1080/2162402X.2017.1386826. eCollection 2018. Oncoimmunology. 2017. PMID: 30524877 Free PMC article.
Here, we show a deleterious role of the TNFalpha/TNFR2/BIRC3/TRAF1 signaling cascade in NK cells from the tumor microenvironment (TME). ...
Here, we show a deleterious role of the TNFalpha/TNFR2/BIRC3/TRAF1 signaling cascade in NK cells from the tumor microenvironment (TME …
279 results