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A tumor-suppressing role of TSPYL2 in thyroid cancer: Through interacting with SIRT1 and repressing SIRT1/AKT pathway.
Zhang X, Wu X, Yao W, Wang YH. Zhang X, et al. Exp Cell Res. 2023 Nov 1;432(1):113777. doi: 10.1016/j.yexcr.2023.113777. Epub 2023 Sep 9. Exp Cell Res. 2023. PMID: 37696385
Thyroid cancer is one of the most common endocrine cancers. Testis-specific protein, Y-encoded-like 2 (TSPYL2) belongs to the TSPY family. Studies show that TSPYL2 plays as a cancer suppressor in several cancers. However, the role of T …
Thyroid cancer is one of the most common endocrine cancers. Testis-specific protein, Y-encoded-like 2 (TSPYL2) belongs …
TSPYL2 reduced gefitinib resistance and DNA damage repair via suppressing SIRT1-mediated FOXO3 deacetylation.
Liu Z, Li C, Yu C, Chen Z, Zhao C, Ye L. Liu Z, et al. Future Med Chem. 2022 Mar;14(6):407-419. doi: 10.4155/fmc-2021-0136. Epub 2022 Feb 22. Future Med Chem. 2022. PMID: 35192400
Background: Colorectal cancer (CRC) is a malignancy with high mortality. TSPYL2 participates in tumor suppression but its role in CRC remains unknown. ...Conclusion: TSPYL2 reduced resistance to GEF and suppressed DNA damage through downregulating SIRT1-media …
Background: Colorectal cancer (CRC) is a malignancy with high mortality. TSPYL2 participates in tumor suppression but its role …
Sex specific regulation of TSPY-Like 2 in the DNA damage response of cancer cells.
Cardano M, Magni M, Alfieri R, Chan SY, Sabbioneda S, Buscemi G, Zannini L. Cardano M, et al. Cell Death Dis. 2023 Mar 15;14(3):197. doi: 10.1038/s41419-023-05722-2. Cell Death Dis. 2023. PMID: 36918555 Free PMC article.
Conversely, in cancer cells, TSPYL2 accumulates only in females or in those male cancer cells that lost the Y-chromosome during the oncogenic process. ...Accordingly, TSPYL2 has been found more frequently mutated in female-specific cancers. ...
Conversely, in cancer cells, TSPYL2 accumulates only in females or in those male cancer cells that lost the Y-chromosom …
CRL2(APPBP2)-mediated TSPYL2 degradation counteracts human mesenchymal stem cell senescence.
Huang D, Zhao Q, Yang K, Lei J, Jing Y, Li H, Zhang C, Ma S, Sun S, Cai Y, Wang G, Qu J, Zhang W, Wang S, Liu GH. Huang D, et al. Sci China Life Sci. 2024 Mar;67(3):460-474. doi: 10.1007/s11427-023-2451-3. Epub 2023 Dec 7. Sci China Life Sci. 2024. PMID: 38170390
Importantly, we identified that CUL2 targets and promotes ubiquitin proteasome-mediated degradation of TSPYL2 (a known negative regulator of proliferation) through the substrate receptor protein APPBP2, which in turn down-regulates one of the canonical aging marker-P21(waf …
Importantly, we identified that CUL2 targets and promotes ubiquitin proteasome-mediated degradation of TSPYL2 (a known negative regul …
TSPYL2 is an essential component of the REST/NRSF transcriptional complex for TGFbeta signaling activation.
Epping MT, Lunardi A, Nachmani D, Castillo-Martin M, Thin TH, Cordon-Cardo C, Pandolfi PP. Epping MT, et al. Cell Death Differ. 2015 Aug;22(8):1353-62. doi: 10.1038/cdd.2014.226. Epub 2015 Jan 23. Cell Death Differ. 2015. PMID: 25613376 Free PMC article.
REST/NRSF is a transcriptional repressor of neuronal genes that has been implicated in development and cancer. In epithelial tissues, REST acts as a tumor suppressor and in breast cancer, loss of REST is associated with disease recurrence and poor prognosis. ...We s …
REST/NRSF is a transcriptional repressor of neuronal genes that has been implicated in development and cancer. In epithelial tissues, …
TSPYL2 Regulates the Expression of EZH2 Target Genes in Neurons.
Liu H, Peng L, So J, Tsang KH, Chong CH, Mak PHS, Chan KM, Chan SY. Liu H, et al. Mol Neurobiol. 2019 Apr;56(4):2640-2652. doi: 10.1007/s12035-018-1238-y. Epub 2018 Jul 26. Mol Neurobiol. 2019. PMID: 30051352 Free PMC article.
We have previously shown that Tspyl2 knockout mice had impaired learning and sensorimotor gating, and TSPYL2 facilitates the expression of Grin2a and Grin2b through interaction with CREB-binding protein. To identify other genes regulated by TSPYL2, here, we s …
We have previously shown that Tspyl2 knockout mice had impaired learning and sensorimotor gating, and TSPYL2 facilitates the e …
TSPYL2 is a novel regulator of SIRT1 and p300 activity in response to DNA damage.
Magni M, Buscemi G, Maita L, Peng L, Chan SY, Montecucco A, Delia D, Zannini L. Magni M, et al. Cell Death Differ. 2019 May;26(5):918-931. doi: 10.1038/s41418-018-0168-6. Epub 2018 Jul 26. Cell Death Differ. 2019. PMID: 30050056 Free PMC article.
Here we identify the nucleosome assembly protein TSPY-Like 2 (TSPYL2, also known as TSPX, DENTT, and CDA1) as a novel regulator of SIRT1 and p300 function. ...Collectively, our results shed new light on the regulation of p53 acetylation and activation and reveal a novel …
Here we identify the nucleosome assembly protein TSPY-Like 2 (TSPYL2, also known as TSPX, DENTT, and CDA1) as a novel regulator of SI …
The role of Testis-Specific Protein Y-encoded-Like 2 in kidney injury.
Sui M, Yan S, Zhang P, Li Y, Chen K, Li Y, Lu H, Li Y, Zhao W, Zeng L. Sui M, et al. iScience. 2024 Mar 27;27(5):109594. doi: 10.1016/j.isci.2024.109594. eCollection 2024 May 17. iScience. 2024. PMID: 38665207 Free PMC article.
However, the role of TSPYL2 in IRI-induced kidney damage is not entirely clear. In this study, we found that the expression of TSPYL2 was upregulated in a mouse model of AKI and in the hypoxia/reoxygenation (H/R) cell model. Knockdown of TSPYL2 attenuated kid …
However, the role of TSPYL2 in IRI-induced kidney damage is not entirely clear. In this study, we found that the expression of TSP …
Ginsenoside Rg3 increases gemcitabine sensitivity of pancreatic adenocarcinoma via reducing ZFP91 mediated TSPYL2 destabilization.
Pan H, Yang L, Bai H, Luo J, Deng Y. Pan H, et al. J Ginseng Res. 2022 Sep;46(5):636-645. doi: 10.1016/j.jgr.2021.08.004. Epub 2021 Aug 30. J Ginseng Res. 2022. PMID: 36090681 Free PMC article.
ZFP91 interacted with Testis-Specific Y-Encoded-Like Protein 2 (TSPYL2), induced its poly-ubiquitination, and promoted proteasomal degradation. Ginsenoside Rg3 treatment weakened ZFP91-induced TSPYL2 poly-ubiquitination and degradation. Enforced TSPYL2 expres …
ZFP91 interacted with Testis-Specific Y-Encoded-Like Protein 2 (TSPYL2), induced its poly-ubiquitination, and promoted proteasomal de …
Unique structural features of the adenylate kinase hCINAP/AK6 and its multifaceted functions in carcinogenesis and tumor progression.
Xu R, Yang Y, Zheng X. Xu R, et al. FEBS Lett. 2021 Aug;595(16):2071-2084. doi: 10.1002/1873-3468.14158. Epub 2021 Jul 20. FEBS Lett. 2021. PMID: 34245011 Free article. Review.
Human coilin-interacting nuclear ATPase protein (hCINAP), also known as adenylate kinase 6 (AK6), is an atypical adenylate kinase with critical roles in many biological processes, including gene transcription, ribosome synthesis, cell metabolism, cell proliferation and apoptosis, …
Human coilin-interacting nuclear ATPase protein (hCINAP), also known as adenylate kinase 6 (AK6), is an atypical adenylate kinase with criti …
29 results