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1995 19
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2001 30
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988 results

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Page 1
Human TYRP1: Two functions for a single gene?
Gautron A, Migault M, Bachelot L, Corre S, Galibert MD, Gilot D. Gautron A, et al. Pigment Cell Melanoma Res. 2021 Sep;34(5):836-852. doi: 10.1111/pcmr.12951. Epub 2021 Feb 16. Pigment Cell Melanoma Res. 2021. PMID: 33305505 Free article. Review.
In this review, we explore one important factor in pigmentation: the tyrosinase-related protein 1 (TYRP1) gene which is involved in eumelanin synthesis via the TYRP1 protein. ...Recently, we were able to explain this unexpected TYRP1 function by demonstrating …
In this review, we explore one important factor in pigmentation: the tyrosinase-related protein 1 (TYRP1) gene which is involved in e …
Tyrp1 and oculocutaneous albinism type 3.
Sarangarajan R, Boissy RE. Sarangarajan R, et al. Pigment Cell Res. 2001 Dec;14(6):437-44. doi: 10.1034/j.1600-0749.2001.140603.x. Pigment Cell Res. 2001. PMID: 11775055 Review.
Mutations in the mouse Tyrp1 gene are associated with brown pelage, and in the human TYRP1 gene with oculocutaneous albinism type 3 (OCA3). In the murine system, Tyrp1 expresses significant dihydroxyindole carboxylic acid oxidase (i.e. ...
Mutations in the mouse Tyrp1 gene are associated with brown pelage, and in the human TYRP1 gene with oculocutaneous albinism t …
Epigenetic regulation of melanogenesis.
Zhou S, Zeng H, Huang J, Lei L, Tong X, Li S, Zhou Y, Guo H, Khan M, Luo L, Xiao R, Chen J, Zeng Q. Zhou S, et al. Ageing Res Rev. 2021 Aug;69:101349. doi: 10.1016/j.arr.2021.101349. Epub 2021 May 10. Ageing Res Rev. 2021. PMID: 33984527 Review.
DNA methylation regulates the expression of key genes such as tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), dopachrome tautomerase (DCT) and microphthalmia-associated transcription factor (MITF), as well as paracrine factors such as stem cell factor (SCF) and end …
DNA methylation regulates the expression of key genes such as tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), dopachrome taut …
Pigmentation and TYRP1 expression are mediated by zinc through the early secretory pathway-resident ZNT proteins.
Wagatsuma T, Suzuki E, Shiotsu M, Sogo A, Nishito Y, Ando H, Hashimoto H, Petris MJ, Kinoshita M, Kambe T. Wagatsuma T, et al. Commun Biol. 2023 Apr 18;6(1):403. doi: 10.1038/s42003-023-04640-5. Commun Biol. 2023. PMID: 37072620 Free PMC article.
Although there is experimental evidence for a copper cofactor in TYR, delivered via the copper transporter, ATP7A, the presence of copper in TYRP1 and TYRP2 has not been demonstrated. Here, we report that the expression and function of TYRP1 requires zinc, mediated …
Although there is experimental evidence for a copper cofactor in TYR, delivered via the copper transporter, ATP7A, the presence of copper in …
Oculocutaneous Albinism and Ocular Albinism Overview.
Thomas MG, Zippin J, Brooks BP. Thomas MG, et al. 2023 Apr 13. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2023 Apr 13. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 37053367 Free Books & Documents. Review.
Tyrp1 Mutant Variants Associated with OCA3: Computational Characterization of Protein Stability and Ligand Binding.
Patel MH, Dolinska MB, Sergeev YV. Patel MH, et al. Int J Mol Sci. 2021 Sep 22;22(19):10203. doi: 10.3390/ijms221910203. Int J Mol Sci. 2021. PMID: 34638544 Free PMC article.
Here, for the first time, four OCA3-causing mutations of Tyrp1, C30R, H215Y, D308N, and R326H, were investigated computationally to understand Tyrp1 protein stability and catalytic activity. Using the Tyrp1 crystal structure (PDB:5M8L), global mutagenesis was …
Here, for the first time, four OCA3-causing mutations of Tyrp1, C30R, H215Y, D308N, and R326H, were investigated computationally to u …
TYRP1 Protects Against the Apoptosis and Oxidative Stress of Retinal Ganglion Cells by Binding to PMEL.
Gao Y, Liu L, Zhang Z, Qin C, Yang B, Ke Y. Gao Y, et al. Ocul Immunol Inflamm. 2023 Jul;31(5):1024-1034. doi: 10.1080/09273948.2022.2081862. Epub 2022 Jun 16. Ocul Immunol Inflamm. 2023. PMID: 35708352
RESULTS: TYRP1 and PMEL expression was poor in glaucoma patients, COH rats, and OGD-RGCs. Mechanistically, TYRP1 interacted with PMEL to upregulate PMEL in OGD-RGCs. TYRP1 overexpression enhanced viability and diminished apoptosis and oxidative stress of OGD- …
RESULTS: TYRP1 and PMEL expression was poor in glaucoma patients, COH rats, and OGD-RGCs. Mechanistically, TYRP1 interacted wi …
TYRP1 mRNA level is stable and MITF-M-independent in drug-naive, vemurafenib- and trametinib-resistant BRAF(V600E) melanoma cells.
Hartman ML, Czyz M. Hartman ML, et al. Arch Dermatol Res. 2020 Jul;312(5):385-392. doi: 10.1007/s00403-019-01995-w. Epub 2019 Oct 17. Arch Dermatol Res. 2020. PMID: 31624899 Free PMC article.
TYRP1 mRNA is of interest due to its potential non-coding role as a sponge sequestering tumor-suppressive miRs in melanoma. ...A time-lapse fluorescence microscope was used to rate proliferation, qRT-PCR and Western blotting were used to assess TYRP1 expression and …
TYRP1 mRNA is of interest due to its potential non-coding role as a sponge sequestering tumor-suppressive miRs in melanoma. ...A time …
Oculocutaneous albinism.
Grønskov K, Ek J, Brondum-Nielsen K. Grønskov K, et al. Orphanet J Rare Dis. 2007 Nov 2;2:43. doi: 10.1186/1750-1172-2-43. Orphanet J Rare Dis. 2007. PMID: 17980020 Free PMC article. Review.
At least four genes are responsible for the different types of the disease (TYR, OCA2, TYRP1 and MATP). Diagnosis is based on clinical findings of hypopigmentation of the skin and hair, in addition to the characteristic ocular symptoms. ...Molecular genetic testing of TYR …
At least four genes are responsible for the different types of the disease (TYR, OCA2, TYRP1 and MATP). Diagnosis is based on clinica …
Biophysical Compatibility of a Heterotrimeric Tyrosinase-TYRP1-TYRP2 Metalloenzyme Complex.
Lavinda O, Manga P, Orlow SJ, Cardozo T. Lavinda O, et al. Front Pharmacol. 2021 Apr 28;12:602206. doi: 10.3389/fphar.2021.602206. eCollection 2021. Front Pharmacol. 2021. PMID: 33995009 Free PMC article.
Accordingly, to investigate whether TYR, TYRP1, and TYRP2 are biophysically compatible with various heterocomplexes, we computationally docked a high-quality 3D model of TYR to the crystal structure of TYRP1 and to a high-quality 3D model of TYRP2. Remarkably, the r …
Accordingly, to investigate whether TYR, TYRP1, and TYRP2 are biophysically compatible with various heterocomplexes, we computational …
988 results