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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
1991 2
1992 4
1993 6
1994 15
1995 9
1996 9
1997 7
1998 15
1999 9
2000 9
2001 12
2002 10
2003 10
2004 8
2005 7
2006 9
2007 9
2008 14
2009 15
2010 12
2011 7
2012 8
2013 11
2014 15
2015 9
2016 6
2017 13
2018 19
2019 13
2020 17
2021 14
2022 21
2023 7
2024 3

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327 results

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Page 1
Oculocutaneous albinism.
Grønskov K, Ek J, Brondum-Nielsen K. Grønskov K, et al. Orphanet J Rare Dis. 2007 Nov 2;2:43. doi: 10.1186/1750-1172-2-43. Orphanet J Rare Dis. 2007. PMID: 17980020 Free PMC article. Review.
The degree of skin and hair hypopigmentation varies with the type of OCA. The incidence of skin cancer may be increased. All four types of OCA are inherited as autosomal recessive disorders. At least four genes are responsible for the different types of the disease (TYR, O …
The degree of skin and hair hypopigmentation varies with the type of OCA. The incidence of skin cancer may be increased. All four typ …
Human TYRP1: Two functions for a single gene?
Gautron A, Migault M, Bachelot L, Corre S, Galibert MD, Gilot D. Gautron A, et al. Pigment Cell Melanoma Res. 2021 Sep;34(5):836-852. doi: 10.1111/pcmr.12951. Epub 2021 Feb 16. Pigment Cell Melanoma Res. 2021. PMID: 33305505 Free article. Review.
In this review, we explore one important factor in pigmentation: the tyrosinase-related protein 1 (TYRP1) gene which is involved in eumelanin synthesis via the TYRP1 protein. ...Recently, we were able to explain this unexpected TYRP1 function by demonstrating …
In this review, we explore one important factor in pigmentation: the tyrosinase-related protein 1 (TYRP1) gene which is involved in e …
The Combination of Niacinamide, Vitamin C, and PDRN Mitigates Melanogenesis by Modulating Nicotinamide Nucleotide Transhydrogenase.
Park HJ, Byun KA, Oh S, Kim HM, Chung MS, Son KH, Byun K. Park HJ, et al. Molecules. 2022 Aug 2;27(15):4923. doi: 10.3390/molecules27154923. Molecules. 2022. PMID: 35956878 Free PMC article.
NVP-mix also decreased MC1R, MITF, TYRP1, TYRP2, RAB32, and RAB27A in melanocytes treated with CM from UV-irradiated keratinocytes. ...In conclusion, NVP-mix decreased mitochondrial oxidative stress by increasing NNT expression and decreased melanogenesis by decreasing MC1 …
NVP-mix also decreased MC1R, MITF, TYRP1, TYRP2, RAB32, and RAB27A in melanocytes treated with CM from UV-irradiated keratinocytes. . …
Ganoderma lucidum polysaccharide inhibits UVB-induced melanogenesis by antagonizing cAMP/PKA and ROS/MAPK signaling pathways.
Hu S, Huang J, Pei S, Ouyang Y, Ding Y, Jiang L, Lu J, Kang L, Huang L, Xiang H, Xiao R, Zeng Q, Chen J. Hu S, et al. J Cell Physiol. 2019 May;234(5):7330-7340. doi: 10.1002/jcp.27492. Epub 2018 Oct 26. J Cell Physiol. 2019. PMID: 30362532
The expression of melanogenesis genes such as microphthalmia-associated transcription factor (MITF), tyrosine (TYR), tyrosinase related protein 1 (TYRP1), tyrosinase related protein 2 (TYRP2), ras-related protein Rab-27A (Rab27A), and Myosin shows an upward trend after exp …
The expression of melanogenesis genes such as microphthalmia-associated transcription factor (MITF), tyrosine (TYR), tyrosinase related prot …
CAR-T cell therapy targeting surface expression of TYRP1 to treat cutaneous and rare melanoma subtypes.
Jilani S, Saco JD, Mugarza E, Pujol-Morcillo A, Chokry J, Ng C, Abril-Rodriguez G, Berger-Manerio D, Pant A, Hu J, Gupta R, Vega-Crespo A, Baselga-Carretero I, Chen JM, Shin DS, Scumpia P, Radu RA, Chen Y, Ribas A, Puig-Saus C. Jilani S, et al. Nat Commun. 2024 Feb 9;15(1):1244. doi: 10.1038/s41467-024-45221-2. Nat Commun. 2024. PMID: 38336975 Free PMC article.
TYRP1 is primarily located intracellularly in the melanosomes, with a small fraction being trafficked to the cell surface via vesicular transport. We develop a highly sensitive CAR-T cell therapy that detects surface TYRP1 in tumor cells with high TYRP1 overe …
TYRP1 is primarily located intracellularly in the melanosomes, with a small fraction being trafficked to the cell surface via vesicul …
Association of TYRP1 with hypoxia and its correlation with patient outcome in uveal melanoma.
Jha J, Singh MK, Singh L, Pushker N, Lomi N, Meel R, Chosdol K, Sen S, Bakhshi S, Kashyap S. Jha J, et al. Clin Transl Oncol. 2021 Sep;23(9):1874-1884. doi: 10.1007/s12094-021-02597-7. Epub 2021 Apr 3. Clin Transl Oncol. 2021. PMID: 33811629

Both TYRP1 and HIF-1alpha correlated well with high pigmentation and BAP1 (BRCA1 Associated Protein-1) loss (p < 0.05) at IHC level as well as transcriptional level. ...Further studies on melanogenesis markers associated with TYRP1 could provide us a better under

…

Both TYRP1 and HIF-1alpha correlated well with high pigmentation and BAP1 (BRCA1 Associated Protein-1) loss (p < 0.05) at IHC leve

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Tyrosinase related protein 1 (TYRP1/gp75) in human cutaneous melanoma.
Ghanem G, Fabrice J. Ghanem G, et al. Mol Oncol. 2011 Apr;5(2):150-5. doi: 10.1016/j.molonc.2011.01.006. Epub 2011 Feb 3. Mol Oncol. 2011. PMID: 21324755 Free PMC article. Review.
The present review focuses on human tyrosinase related protein 1 also known as gp75 glycoprotein (Tyrp1/gp75), a melanosomal protein involved in the pigmentary machinery of the melanocyte and often used as differentiation marker, with a special emphasis on its emerging rol …
The present review focuses on human tyrosinase related protein 1 also known as gp75 glycoprotein (Tyrp1/gp75), a melanosomal protein …
Bispecific antibodies redirect synthetic agonistic receptor modified T cells against melanoma.
Märkl F, Benmebarek MR, Keyl J, Cadilha BL, Geiger M, Karches C, Obeck H, Schwerdtfeger M, Michaelides S, Briukhovetska D, Stock S, Jobst J, Müller PJ, Majed L, Seifert M, Klüver AK, Lorenzini T, Grünmeier R, Thomas M, Gottschlich A, Klaus R, Marr C, von Bergwelt-Baildon M, Rothenfusser S, Levesque MP, Heppt MV, Endres S, Klein C, Kobold S. Märkl F, et al. J Immunother Cancer. 2023 May;11(5):e006436. doi: 10.1136/jitc-2022-006436. J Immunother Cancer. 2023. PMID: 37208128 Free PMC article.
The approach was validated in murine, human and patient-derived cancer models expressing the melanoma-associated target antigens tyrosinase-related protein 1 (TYRP1) and melanoma-associated chondroitin sulfate proteoglycan (MCSP) (CSPG4). ...The presence of target c …
The approach was validated in murine, human and patient-derived cancer models expressing the melanoma-associated target antigens tyro …
TYRP1 mRNA level is stable and MITF-M-independent in drug-naive, vemurafenib- and trametinib-resistant BRAF(V600E) melanoma cells.
Hartman ML, Czyz M. Hartman ML, et al. Arch Dermatol Res. 2020 Jul;312(5):385-392. doi: 10.1007/s00403-019-01995-w. Epub 2019 Oct 17. Arch Dermatol Res. 2020. PMID: 31624899 Free PMC article.
TYRP1 mRNA is of interest due to its potential non-coding role as a sponge sequestering tumor-suppressive miRs in melanoma. ...A time-lapse fluorescence microscope was used to rate proliferation, qRT-PCR and Western blotting were used to assess TYRP1 expression and …
TYRP1 mRNA is of interest due to its potential non-coding role as a sponge sequestering tumor-suppressive miRs in melanoma. ...A time …
The tyrosinase related protein-1 (Tyrp1) promoter in transgenic experiments: targeted expression to the retinal pigment epithelium.
Beermann F. Beermann F. Cell Mol Biol (Noisy-le-grand). 1999 Nov;45(7):961-8. Cell Mol Biol (Noisy-le-grand). 1999. PMID: 10644000 Review.
We have chosen 1.4 kb and 4 kb from the promoter of the tyrosinase-related protein 1 gene (Tyrp1) for RPE-specific expression, since Tyrp1 mRNA and protein are detected already at midgestation in this epithelial layer. ...In addition, Tyrp1-Rfp/Ret expression …
We have chosen 1.4 kb and 4 kb from the promoter of the tyrosinase-related protein 1 gene (Tyrp1) for RPE-specific expression, since …
327 results