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Transcriptomic and proteomic study of cancer cell lines exposed to actinomycin D and nutlin-3a reveals numerous, novel candidates for p53-regulated genes.
Łasut-Szyszka B, Gdowicz-Kłosok A, Małachowska B, Krześniak M, Będzińska A, Gawin M, Pietrowska M, Rusin M. Łasut-Szyszka B, et al. Chem Biol Interact. 2024 Apr 1;392:110946. doi: 10.1016/j.cbi.2024.110946. Epub 2024 Mar 7. Chem Biol Interact. 2024. PMID: 38460933
Moreover, several identified genes code for antagonists of WNT/beta-catenin signalling pathways, which suggests new connections between these two cancer-related signalling systems. One of these antagonists is DRAXIN. ...Thus, this protein functions not only in the developm …
Moreover, several identified genes code for antagonists of WNT/beta-catenin signalling pathways, which suggests new connections between thes …
Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism.
Yamashita A, Ignatenko O, Nguyen M, Lambert R, Watt K, Daneault C, Robillard-Frayne I, Topisirovic I, Rosiers CD, McBride HM. Yamashita A, et al. Biol Direct. 2023 Sep 22;18(1):60. doi: 10.1186/s13062-023-00416-3. Biol Direct. 2023. PMID: 37736739 Free PMC article.
Depletion of LONP2 triggered the accumulation of its substrate TYSND1 protease, while the overall expression of peroxisomal proteins, as well as TYSND1-dependent ACOX1 processing appeared normal, reflecting early stages of peroxisomal proteotoxic stress. ...
Depletion of LONP2 triggered the accumulation of its substrate TYSND1 protease, while the overall expression of peroxisomal proteins, …