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2006 4
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Page 1
TAAR1 and Psychostimulant Addiction.
Liu J, Wu R, Li JX. Liu J, et al. Cell Mol Neurobiol. 2020 Mar;40(2):229-238. doi: 10.1007/s10571-020-00792-8. Epub 2020 Jan 23. Cell Mol Neurobiol. 2020. PMID: 31974906 Free PMC article. Review.
In the last decade, many preclinical models of psychostimulant addiction such as drug-induced behavioral sensitization, drug-induced conditioned place preference, drug self-administration, drug discrimination, and relapse models were used to assess the effects of TAAR1 ago …
In the last decade, many preclinical models of psychostimulant addiction such as drug-induced behavioral sensitization, drug-induced conditi …
TAAR1 in Addiction: Looking Beyond the Tip of the Iceberg.
Liu JF, Li JX. Liu JF, et al. Front Pharmacol. 2018 Mar 27;9:279. doi: 10.3389/fphar.2018.00279. eCollection 2018. Front Pharmacol. 2018. PMID: 29636691 Free PMC article. Review.
Trace-amine associated receptor 1 (TAAR1) is the best-characterized member of the family of TAARs. TAAR1 is broadly expressed in the brain, especially within the monoaminergic systems. ...In addition, the alternative cellular mechanism such as an interaction between …
Trace-amine associated receptor 1 (TAAR1) is the best-characterized member of the family of TAARs. TAAR1 is broadly expressed …
Trace amine-associated receptor 1 (TAAR1) agonism as a new treatment strategy for schizophrenia and related disorders.
Halff EF, Rutigliano G, Garcia-Hidalgo A, Howes OD. Halff EF, et al. Trends Neurosci. 2023 Jan;46(1):60-74. doi: 10.1016/j.tins.2022.10.010. Epub 2022 Nov 8. Trends Neurosci. 2023. PMID: 36369028 Free article. Review.
We then consider how the localisation and function of the trace amine-associated receptor 1 (TAAR1) position it to modulate key brain circuits for the disorder. Studies in rodents using Taar1 knockout (TAAR1-KO) and overexpression models show that TAAR1 …
We then consider how the localisation and function of the trace amine-associated receptor 1 (TAAR1) position it to modulate key brain …
Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP. Shang P, et al. Cell. 2023 Nov 22;186(24):5347-5362.e24. doi: 10.1016/j.cell.2023.10.014. Epub 2023 Nov 13. Cell. 2023. PMID: 37963465
Here, we systematically profiled the signaling properties of TAAR1 activation and present nine structures of TAAR1-Gs/Gq in complex with EAMs, clinical drugs, and synthetic compounds. ...Our results provided a structural and signaling framework for molecular recogni …
Here, we systematically profiled the signaling properties of TAAR1 activation and present nine structures of TAAR1-Gs/Gq in co …
TAAR1 as an emerging target for the treatment of psychiatric disorders.
Liu J, Wu R, Li JX. Liu J, et al. Pharmacol Ther. 2024 Jan;253:108580. doi: 10.1016/j.pharmthera.2023.108580. Epub 2023 Dec 22. Pharmacol Ther. 2024. PMID: 38142862 Review.
We also discuss the potential TAAR1-dependent signaling pathways and the cellular mechanisms underlying the inhibitory effects of TAAR1 activation on drug addiction. We conclude that TAAR1 is an emerging target for the treatment of psychiatric disorders....
We also discuss the potential TAAR1-dependent signaling pathways and the cellular mechanisms underlying the inhibitory effects of …
Recognition of methamphetamine and other amines by trace amine receptor TAAR1.
Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, Xu HE, Xu F. Liu H, et al. Nature. 2023 Dec;624(7992):663-671. doi: 10.1038/s41586-023-06775-1. Epub 2023 Nov 7. Nature. 2023. PMID: 37935377
Given its unique physiological role in the brain, TAAR1 is also an emerging target for a range of neurological disorders including schizophrenia, depression and drug addiction(2,4,5). Here we report structures of human TAAR1-G-protein complexes bound to methamphetam …
Given its unique physiological role in the brain, TAAR1 is also an emerging target for a range of neurological disorders including sc …
Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z. Xu Z, et al. Nature. 2023 Dec;624(7992):672-681. doi: 10.1038/s41586-023-06804-z. Epub 2023 Nov 7. Nature. 2023. PMID: 37935376
These structures reveal a rigid consensus binding motif in TAAR1 that binds to endogenous trace amine stimuli and two extended binding pockets that accommodate diverse chemotypes. Combined with mutational analysis, functional assays and molecular dynamic simulations, we el …
These structures reveal a rigid consensus binding motif in TAAR1 that binds to endogenous trace amine stimuli and two extended bindin …
The Case for TAAR1 as a Modulator of Central Nervous System Function.
Rutigliano G, Accorroni A, Zucchi R. Rutigliano G, et al. Front Pharmacol. 2018 Jan 10;8:987. doi: 10.3389/fphar.2017.00987. eCollection 2017. Front Pharmacol. 2018. PMID: 29375386 Free PMC article. Review.
However, the subcellular distribution of TAAR1 is still unclear, since TAAR1 signal is largely intracellular. ...In conclusion, the bulk of evidence points to a significant physiological role of TAAR1 in the modulation of central nervous system function and a …
However, the subcellular distribution of TAAR1 is still unclear, since TAAR1 signal is largely intracellular. ...In conclusion …
Trace amine associated receptor 1 (TAAR1) modulators: a patent review (2010-present).
Tonelli M, Cichero E. Tonelli M, et al. Expert Opin Ther Pat. 2020 Feb;30(2):137-145. doi: 10.1080/13543776.2020.1708900. Epub 2019 Dec 25. Expert Opin Ther Pat. 2020. PMID: 31865810 Review.
Introduction: The greater interest in TAAR1-mediated potential for the treatment of different pathologies, especially those related to CNS disorders, has given a considerable boost to the search for developing TAAR1-selective small molecules.Areas covered: During th …
Introduction: The greater interest in TAAR1-mediated potential for the treatment of different pathologies, especially those related t …
Therapeutic Potential of TAAR1 Agonists in Schizophrenia: Evidence from Preclinical Models and Clinical Studies.
Dedic N, Dworak H, Zeni C, Rutigliano G, Howes OD. Dedic N, et al. Int J Mol Sci. 2021 Dec 7;22(24):13185. doi: 10.3390/ijms222413185. Int J Mol Sci. 2021. PMID: 34947997 Free PMC article. Review.
Clinical trial data for TAAR1 drug candidates are reviewed and contrasted with antipsychotics. The identification of endogenous TAAR1 ligands and subsequent development of small-molecule agonists has revealed antipsychotic-, anxiolytic-, and antidepressant-like prop …
Clinical trial data for TAAR1 drug candidates are reviewed and contrasted with antipsychotics. The identification of endogenous TA …
349 results