Tachibana K - Search Results

1

Design and synthesis of an androgen receptor pure antagonist (CH5137291) for the treatment of castration-resistant prostate cancer.

Yoshino H, Sato H, Shiraishi T, Tachibana K, Emura T, Honma A, Ishikura N, Tsunenari T, Watanabe M, Nishimoto A, Nakamura R, Nakagawa T, Ohta M, Takata N, Furumoto K, Kimura K, Kawata H. Yoshino H, et al. Among authors: tachibana k. Bioorg Med Chem. 2010 Dec 1;18(23):8150-7. doi: 10.1016/j.bmc.2010.10.023. Epub 2010 Oct 15. Bioorg Med Chem. 2010. PMID: 21050768

2

Discovery of 7alpha-substituted dihydrotestosterones as androgen receptor pure antagonists and their structure-activity relationships.

Tachibana K, Imaoka I, Yoshino H, Emura T, Kodama H, Furuta Y, Kato N, Nakamura M, Ohta M, Taniguchi K, Ishikura N, Nagamuta M, Onuma E, Sato H. Tachibana K, et al. Bioorg Med Chem. 2007 Jan 1;15(1):174-85. doi: 10.1016/j.bmc.2006.09.072. Epub 2006 Oct 4. Bioorg Med Chem. 2007. PMID: 17064916

3

Discovery and structure-activity relationships of new steroidal compounds bearing a carboxy-terminal side chain as androgen receptor pure antagonists.

Tachibana K, Imaoka I, Yoshino H, Kato N, Nakamura M, Ohta M, Kawata H, Taniguchi K, Ishikura N, Nagamuta M, Onuma E, Sato H. Tachibana K, et al. Bioorg Med Chem Lett. 2007 Oct 15;17(20):5573-6. doi: 10.1016/j.bmcl.2007.07.090. Epub 2007 Aug 22. Bioorg Med Chem Lett. 2007. PMID: 17804229

4

Discovery of an orally-active nonsteroidal androgen receptor pure antagonist and the structure-activity relationships of its derivatives.

Tachibana K, Imaoka I, Shiraishi T, Yoshino H, Nakamura M, Ohta M, Kawata H, Taniguchi K, Ishikura N, Tsunenari T, Saito H, Nagamuta M, Nakagawa T, Takanashi K, Onuma E, Sato H. Tachibana K, et al. Chem Pharm Bull (Tokyo). 2008 Nov;56(11):1555-61. doi: 10.1248/cpb.56.1555. Chem Pharm Bull (Tokyo). 2008. PMID: 18981605 Free article.

5

Structure-activity relationships of bioisosteric replacement of the carboxylic acid in novel androgen receptor pure antagonists.

Yoshino H, Sato H, Tachibana K, Shiraishi T, Nakamura M, Ohta M, Ishikura N, Nagamuta M, Onuma E, Nakagawa T, Arai S, Ahn KH, Jung KY, Kawata H. Yoshino H, et al. Among authors: tachibana k. Bioorg Med Chem. 2010 May 1;18(9):3159-68. doi: 10.1016/j.bmc.2010.03.036. Epub 2010 Mar 19. Bioorg Med Chem. 2010. PMID: 20381361

6

Biological properties of androgen receptor pure antagonist for treatment of castration-resistant prostate cancer: optimization from lead compound to CH5137291.

Kawata H, Arai S, Nakagawa T, Ishikura N, Nishimoto A, Yoshino H, Shiraishi T, Tachibana K, Nakamura R, Sato H. Kawata H, et al. Among authors: tachibana k. Prostate. 2011 Sep;71(12):1344-56. doi: 10.1002/pros.21351. Epub 2011 Feb 9. Prostate. 2011. PMID: 21308717

7

CH5137291, an androgen receptor nuclear translocation-inhibiting compound, inhibits the growth of castration-resistant prostate cancer cells.

Ishikura N, Kawata H, Nishimoto A, Nakamura R, Tsunenari T, Watanabe M, Tachibana K, Shiraishi T, Yoshino H, Honma A, Emura T, Ohta M, Nakagawa T, Houjo T, Corey E, Vessella RL, Aoki Y, Sato H. Ishikura N, et al. Among authors: tachibana k. Int J Oncol. 2015 Apr;46(4):1560-72. doi: 10.3892/ijo.2015.2860. Epub 2015 Jan 30. Int J Oncol. 2015. PMID: 25634071

8

Efficient asymmetric synthesis of novel gastrin receptor antagonist AG-041R via highly stereoselective alkylation of oxindole enolates.

Emura T, Esaki T, Tachibana K, Shimizu M. Emura T, et al. Among authors: tachibana k. J Org Chem. 2006 Oct 27;71(22):8559-64. doi: 10.1021/jo061541v. J Org Chem. 2006. PMID: 17064034

9

2(1H)-quinolinone derivatives as novel anti-arteriostenotic agents showing anti-thrombotic and anti-hyperplastic activities.

Koga Y, Kihara Y, Okada M, Inoue Y, Tochizawa S, Toga K, Tachibana K, Kimura Y, Nishi T, Hidaka H. Koga Y, et al. Among authors: tachibana k. Bioorg Med Chem Lett. 1998 Jun 16;8(12):1471-6. doi: 10.1016/s0960-894x(98)00246-7. Bioorg Med Chem Lett. 1998. PMID: 9873372

10

Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity.

Sudo T, Tachibana K, Toga K, Tochizawa S, Inoue Y, Kimura Y, Hidaka H. Sudo T, et al. Among authors: tachibana k. Biochem Pharmacol. 2000 Feb 15;59(4):347-56. doi: 10.1016/s0006-2952(99)00346-9. Biochem Pharmacol. 2000. PMID: 10644042

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