Functional interrogation of twenty type 2 diabetes-associated genes using isogenic hESC-derived β-like cells.
Xue D, Narisu N, Taylor DL, Zhang M, Grenko C, Taylor HJ, Yan T, Tang X, Sinha N, Zhu J, Vandana JJ, Chong ACN, Lee A, Mansell EC, Swift AJ, Erdos MR, Zhou T, Bonnycastle LL, Zhong A, Chen S, Collins FS.
Xue D, et al.
bioRxiv [Preprint]. 2023 May 8:2023.05.07.539774. doi: 10.1101/2023.05.07.539774.
bioRxiv. 2023.
PMID: 37214922
Free PMC article.
Updated.
Preprint.
In addition, we performed integrative association analyses and identified four genes ( CP, RNASE1, PCSK1N and GSTA2 ) associated with insulin production, and two genes ( TAGLN3 and DHRS2 ) associated with sensitivity to lipotoxicity. Finally, we leveraged deep ATAC-seq rea …
In addition, we performed integrative association analyses and identified four genes ( CP, RNASE1, PCSK1N and GSTA2 ) associated with insuli …