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Year Number of Results
2001 2
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2005 2
2006 2
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2014 1
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2018 2
2019 1
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2023 2
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Page 1
APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-kappaB activation.
Arnaud L, Benech P, Greetham L, Stephan D, Jimenez A, Jullien N, García-González L, Tsvetkov PO, Devred F, Sancho-Martinez I, Izpisua Belmonte JC, Baranger K, Rivera S, Nivet E. Arnaud L, et al. Cell Rep. 2022 Aug 16;40(7):111200. doi: 10.1016/j.celrep.2022.111200. Cell Rep. 2022. PMID: 35977506 Free article.
We show that APOE4 exerts a dominant negative effect to prime astrocytes toward a pro-inflammatory state that is pharmacologically reversible by TAGLN3 supplementation. We further confirm that TAGLN3 is downregulated in the brain of patients with sAD. Our findings h …
We show that APOE4 exerts a dominant negative effect to prime astrocytes toward a pro-inflammatory state that is pharmacologically reversibl …
Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells.
Xue D, Narisu N, Taylor DL, Zhang M, Grenko C, Taylor HJ, Yan T, Tang X, Sinha N, Zhu J, Vandana JJ, Nok Chong AC, Lee A, Mansell EC, Swift AJ, Erdos MR, Zhong A, Bonnycastle LL, Zhou T, Chen S, Collins FS. Xue D, et al. Cell Metab. 2023 Nov 7;35(11):1897-1914.e11. doi: 10.1016/j.cmet.2023.09.013. Epub 2023 Oct 18. Cell Metab. 2023. PMID: 37858332 Free article.
Additionally, the integrative association analyses identified four genes (CP, RNASE1, PCSK1N, and GSTA2) associated with insulin production, and two genes (TAGLN3 and DHRS2) associated with beta cell sensitivity to lipotoxicity. ...
Additionally, the integrative association analyses identified four genes (CP, RNASE1, PCSK1N, and GSTA2) associated with insulin production, …
Epigenetic signature of preterm birth in adult twins.
Tan Q, Li S, Frost M, Nygaard M, Soerensen M, Larsen M, Christensen K, Christiansen L. Tan Q, et al. Clin Epigenetics. 2018 Jun 27;10:87. doi: 10.1186/s13148-018-0518-8. eCollection 2018. Clin Epigenetics. 2018. PMID: 29983834 Free PMC article.
RESULTS: Association analysis detected three genomic regions annotated to the SDHAP3, TAGLN3 and GSTT1 genes on chromosomes 5, 3 and 22 (FWER: 0.01, 0.02 and 0.04) respectively. ...
RESULTS: Association analysis detected three genomic regions annotated to the SDHAP3, TAGLN3 and GSTT1 genes on chromosomes 5, 3 and …
Functional interrogation of twenty type 2 diabetes-associated genes using isogenic hESC-derived β-like cells.
Xue D, Narisu N, Taylor DL, Zhang M, Grenko C, Taylor HJ, Yan T, Tang X, Sinha N, Zhu J, Vandana JJ, Chong ACN, Lee A, Mansell EC, Swift AJ, Erdos MR, Zhou T, Bonnycastle LL, Zhong A, Chen S, Collins FS. Xue D, et al. bioRxiv [Preprint]. 2023 May 8:2023.05.07.539774. doi: 10.1101/2023.05.07.539774. bioRxiv. 2023. PMID: 37214922 Free PMC article. Updated. Preprint.
In addition, we performed integrative association analyses and identified four genes ( CP, RNASE1, PCSK1N and GSTA2 ) associated with insulin production, and two genes ( TAGLN3 and DHRS2 ) associated with sensitivity to lipotoxicity. Finally, we leveraged deep ATAC-seq rea …
In addition, we performed integrative association analyses and identified four genes ( CP, RNASE1, PCSK1N and GSTA2 ) associated with insuli …
Dynamic expression of Notch-dependent neurogenic markers in the chick embryonic nervous system.
Ratié L, Ware M, Jagline H, David V, Dupé V. Ratié L, et al. Front Neuroanat. 2014 Dec 18;8:158. doi: 10.3389/fnana.2014.00158. eCollection 2014. Front Neuroanat. 2014. PMID: 25565981 Free PMC article.
Their temporal and spatial expression were compared with the neuronal markers Nescient Helix-Loop-Helix 1 (Nhlh1), Stathmin 2 (Stmn2) and HuC/D. We show that Tagln3 is an early marker for post-mitotic neurons whereas Chga and Cntn2 are expressed in mature neurons. We demon …
Their temporal and spatial expression were compared with the neuronal markers Nescient Helix-Loop-Helix 1 (Nhlh1), Stathmin 2 (Stmn2) and Hu …
TAGLN2 polymerizes G-actin in a low ionic state but blocks Arp2/3-nucleated actin branching in physiological conditions.
Kim HR, Kwon MS, Lee S, Mun Y, Lee KS, Kim CH, Na BR, Kim BNR, Piragyte I, Lee HS, Jun Y, Jin MS, Hyun YM, Jung HS, Mun JY, Jun CD. Kim HR, et al. Sci Rep. 2018 Apr 3;8(1):5503. doi: 10.1038/s41598-018-23816-2. Sci Rep. 2018. PMID: 29615809 Free PMC article.
However, their fundamental characteristics in regulation of the actin-based cytoskeleton are not fully understood. Here we show that TAGLN2 (including TAGLN1 and TAGLN3) extensively nucleates G-actin polymerization under low-salt conditions, where polymerization would be c …
However, their fundamental characteristics in regulation of the actin-based cytoskeleton are not fully understood. Here we show that TAGLN2 …
Long non-coding RNA LINC01018 inhibits human glioma cell proliferation and metastasis by directly targeting miRNA-182-5p.
Su H, Hailin Z, Dongdong L, Jiang Y, Shuncheng H, Shun Z, Dan L, Biao P. Su H, et al. J Neurooncol. 2022 Oct;160(1):67-78. doi: 10.1007/s11060-022-04113-5. Epub 2022 Sep 12. J Neurooncol. 2022. PMID: 36094613
Lastly, the bioinformatics analyses revealed that LINC01018/miR-182-5p axis mediated a cluster of downstream genes (ADRA2C, RAB6B, RAB27B, RAPGEF5, STEAP2, TAGLN3, and UNC13C), which were potential key factors in the development of glioma. ...
Lastly, the bioinformatics analyses revealed that LINC01018/miR-182-5p axis mediated a cluster of downstream genes (ADRA2C, RAB6B, RAB27B, R …
The canonical smooth muscle cell marker TAGLN is present in endothelial cells and is involved in angiogenesis.
Tsuji-Tamura K, Morino-Koga S, Suzuki S, Ogawa M. Tsuji-Tamura K, et al. J Cell Sci. 2021 Aug 1;134(15):jcs254920. doi: 10.1242/jcs.254920. Epub 2021 Aug 2. J Cell Sci. 2021. PMID: 34338296
Genetic disruption of TAGLN augmented angiogenic behaviors of HUVECs, as did the disruption of TAGLN2 and TAGLN3 genes. Tagln expression was found in ECs in mouse embryos. ...
Genetic disruption of TAGLN augmented angiogenic behaviors of HUVECs, as did the disruption of TAGLN2 and TAGLN3 genes. Tagln express …
Novel genes upregulated when NOTCH signalling is disrupted during hypothalamic development.
Ratié L, Ware M, Barloy-Hubler F, Romé H, Gicquel I, Dubourg C, David V, Dupé V. Ratié L, et al. Neural Dev. 2013 Dec 23;8:25. doi: 10.1186/1749-8104-8-25. Neural Dev. 2013. PMID: 24360028 Free PMC article.
Most importantly, we have taken advantage of this model to identify novel targets of Notch signalling, such as Tagln3 and Chga, which were expressed in hypothalamic neuronal nuclei. ...
Most importantly, we have taken advantage of this model to identify novel targets of Notch signalling, such as Tagln3 and Chga, which …
20 results