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Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.
Staels B, Rubenstrunk A, Noel B, Rigou G, Delataille P, Millatt LJ, Baron M, Lucas A, Tailleux A, Hum DW, Ratziu V, Cariou B, Hanf R. Staels B, et al. Among authors: tailleux a. Hepatology. 2013 Dec;58(6):1941-52. doi: 10.1002/hep.26461. Epub 2013 Oct 29. Hepatology. 2013. PMID: 23703580 Clinical Trial.
The RXR agonist bexarotene improves cholesterol homeostasis and inhibits atherosclerosis progression in a mouse model of mixed dyslipidemia.
Lalloyer F, Fiévet C, Lestavel S, Torpier G, van der Veen J, Touche V, Bultel S, Yous S, Kuipers F, Paumelle R, Fruchart JC, Staels B, Tailleux A. Lalloyer F, et al. Among authors: tailleux a. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2731-7. doi: 10.1161/01.ATV.0000248101.93488.84. Epub 2006 Sep 28. Arterioscler Thromb Vasc Biol. 2006. PMID: 17008586
Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives.
Charton J, Deprez-Poulain R, Hennuyer N, Tailleux A, Staels B, Deprez B. Charton J, et al. Among authors: tailleux a. Bioorg Med Chem Lett. 2009 Jan 15;19(2):489-92. doi: 10.1016/j.bmcl.2008.11.040. Epub 2008 Nov 18. Bioorg Med Chem Lett. 2009. PMID: 19058965 Free article.
Rexinoid bexarotene modulates triglyceride but not cholesterol metabolism via gene-specific permissivity of the RXR/LXR heterodimer in the liver.
Lalloyer F, Pedersen TA, Gross B, Lestavel S, Yous S, Vallez E, Gustafsson JA, Mandrup S, Fiévet C, Staels B, Tailleux A. Lalloyer F, et al. Among authors: tailleux a. Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1488-95. doi: 10.1161/ATVBAHA.109.189506. Epub 2009 Jul 10. Arterioscler Thromb Vasc Biol. 2009. PMID: 19592467 Free PMC article.
Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARγ and LXRα pathways.
Chinetti-Gbaguidi G, Baron M, Bouhlel MA, Vanhoutte J, Copin C, Sebti Y, Derudas B, Mayi T, Bories G, Tailleux A, Haulon S, Zawadzki C, Jude B, Staels B. Chinetti-Gbaguidi G, et al. Among authors: tailleux a. Circ Res. 2011 Apr 15;108(8):985-95. doi: 10.1161/CIRCRESAHA.110.233775. Epub 2011 Feb 24. Circ Res. 2011. PMID: 21350215 Free PMC article.
Peroxisome proliferator-activated receptor-alpha gene level differently affects lipid metabolism and inflammation in apolipoprotein E2 knock-in mice.
Lalloyer F, Wouters K, Baron M, Caron S, Vallez E, Vanhoutte J, Baugé E, Shiri-Sverdlov R, Hofker M, Staels B, Tailleux A. Lalloyer F, et al. Among authors: tailleux a. Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1573-9. doi: 10.1161/ATVBAHA.110.220525. Epub 2011 Apr 7. Arterioscler Thromb Vasc Biol. 2011. PMID: 21474829 Free PMC article.
105 results