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Raloxifene inhibits estrogen-induced up-regulation of telomerase activity in a human breast cancer cell line.
Kawagoe J, Ohmichi M, Takahashi T, Ohshima C, Mabuchi S, Takahashi K, Igarashi H, Mori-Abe A, Saitoh M, Du B, Ohta T, Kimura A, Kyo S, Inoue M, Kurachi H. Kawagoe J, et al. Among authors: takahashi k, takahashi t. J Biol Chem. 2003 Oct 31;278(44):43363-72. doi: 10.1074/jbc.M304363200. Epub 2003 Aug 13. J Biol Chem. 2003. PMID: 12917431 Free article.
Inhibition of inhibitor of nuclear factor-kappaB phosphorylation increases the efficacy of paclitaxel in in vitro and in vivo ovarian cancer models.
Mabuchi S, Ohmichi M, Nishio Y, Hayasaka T, Kimura A, Ohta T, Kawagoe J, Takahashi K, Yada-Hashimoto N, Seino-Noda H, Sakata M, Motoyama T, Kurachi H, Testa JR, Tasaka K, Murata Y. Mabuchi S, et al. Among authors: takahashi k. Clin Cancer Res. 2004 Nov 15;10(22):7645-54. doi: 10.1158/1078-0432.CCR-04-0958. Clin Cancer Res. 2004. PMID: 15569997
Both estrogen and raloxifene protect against beta-amyloid-induced neurotoxicity in estrogen receptor alpha-transfected PC12 cells by activation of telomerase activity via Akt cascade.
Du B, Ohmichi M, Takahashi K, Kawagoe J, Ohshima C, Igarashi H, Mori-Abe A, Saitoh M, Ohta T, Ohishi A, Doshida M, Tezuka N, Takahashi T, Kurachi H. Du B, et al. Among authors: takahashi k, takahashi t. J Endocrinol. 2004 Dec;183(3):605-15. doi: 10.1677/joe.1.05775. J Endocrinol. 2004. PMID: 15590986
Growth factors change nuclear distribution of estrogen receptor-alpha via mitogen-activated protein kinase or phosphatidylinositol 3-kinase cascade in a human breast cancer cell line.
Takahashi T, Ohmichi M, Kawagoe J, Ohshima C, Doshida M, Ohta T, Saitoh M, Mori-Abe A, Du B, Igarashi H, Takahashi K, Kurachi H. Takahashi T, et al. Among authors: takahashi k. Endocrinology. 2005 Sep;146(9):4082-9. doi: 10.1210/en.2005-0302. Epub 2005 Jun 9. Endocrinology. 2005. PMID: 15947004
Medroxyprogesterone acetate induces cell proliferation through up-regulation of cyclin D1 expression via phosphatidylinositol 3-kinase/Akt/nuclear factor-kappaB cascade in human breast cancer cells.
Saitoh M, Ohmichi M, Takahashi K, Kawagoe J, Ohta T, Doshida M, Takahashi T, Igarashi H, Mori-Abe A, Du B, Tsutsumi S, Kurachi H. Saitoh M, et al. Among authors: takahashi k, takahashi t. Endocrinology. 2005 Nov;146(11):4917-25. doi: 10.1210/en.2004-1535. Epub 2005 Aug 25. Endocrinology. 2005. PMID: 16123159
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