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Identification of N-substituted 8-azatetrahydroquinolone derivatives as selective and orally active M(1) and M(4) muscarinic acetylcholine receptors agonists.
Takai K, Inoue Y, Konishi Y, Suwa A, Uruno Y, Matsuda H, Nakako T, Sakai M, Nishikawa H, Hashimoto G, Enomoto T, Kitamura A, Uematsu Y, Kiyoshi A, Sumiyoshi T. Takai K, et al. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4644-7. doi: 10.1016/j.bmcl.2013.06.013. Epub 2013 Jun 13. Bioorg Med Chem Lett. 2013. PMID: 23816371
Discovery of N-substituted 7-azaindoline derivatives as potent, orally available M1 and M4 muscarinic acetylcholine receptors selective agonists.
Takai K, Inoue Y, Konishi Y, Suwa A, Uruno Y, Matsuda H, Nakako T, Sakai M, Nishikawa H, Hashimoto G, Enomoto T, Kitamura A, Uematsu Y, Kiyoshi A, Sumiyoshi T. Takai K, et al. Bioorg Med Chem Lett. 2014 Jul 15;24(14):3189-93. doi: 10.1016/j.bmcl.2014.04.085. Epub 2014 May 10. Bioorg Med Chem Lett. 2014. PMID: 24856064
Discovery of novel N-substituted oxindoles as selective m1 and m4 muscarinic acetylcholine receptors partial agonists.
Sumiyoshi T, Enomoto T, Takai K, Takahashi Y, Konishi Y, Uruno Y, Tojo K, Suwa A, Matsuda H, Nakako T, Sakai M, Kitamura A, Uematsu Y, Kiyoshi A. Sumiyoshi T, et al. Among authors: takai k. ACS Med Chem Lett. 2013 Jan 27;4(2):244-8. doi: 10.1021/ml300372f. eCollection 2013 Feb 14. ACS Med Chem Lett. 2013. PMID: 24900656 Free PMC article.
Switching from blonanserin oral tablets/powders to transdermal patches alleviates extrapyramidal symptoms in patients with schizophrenia: A 52-week open-label study.
Ohi K, Takai K, Kuramitsu A, Sugiyama S, Shioiri T. Ohi K, et al. Among authors: takai k. Prog Neuropsychopharmacol Biol Psychiatry. 2022 Mar 8;113:110470. doi: 10.1016/j.pnpbp.2021.110470. Epub 2021 Nov 3. Prog Neuropsychopharmacol Biol Psychiatry. 2022. PMID: 34740708 Free article. Clinical Trial.
1,024 results