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TINF2 is a haploinsufficient tumor suppressor that limits telomere length.
Schmutz I, Mensenkamp AR, Takai KK, Haadsma M, Spruijt L, de Voer RM, Choo SS, Lorbeer FK, van Grinsven EJ, Hockemeyer D, Jongmans MC, de Lange T. Schmutz I, et al. Among authors: takai kk. Elife. 2020 Dec 1;9:e61235. doi: 10.7554/eLife.61235. Elife. 2020. PMID: 33258446 Free PMC article.
Telomere protection by mammalian Pot1 requires interaction with Tpp1.
Hockemeyer D, Palm W, Else T, Daniels JP, Takai KK, Ye JZ, Keegan CE, de Lange T, Hammer GD. Hockemeyer D, et al. Among authors: takai kk. Nat Struct Mol Biol. 2007 Aug;14(8):754-61. doi: 10.1038/nsmb1270. Epub 2007 Jul 15. Nat Struct Mol Biol. 2007. PMID: 17632522
In vivo stoichiometry of shelterin components.
Takai KK, Hooper S, Blackwood S, Gandhi R, de Lange T. Takai KK, et al. J Biol Chem. 2010 Jan 8;285(2):1457-67. doi: 10.1074/jbc.M109.038026. Epub 2009 Oct 28. J Biol Chem. 2010. PMID: 19864690 Free PMC article.
Break-induced replication promotes fragile telomere formation.
Yang Z, Takai KK, Lovejoy CA, de Lange T. Yang Z, et al. Among authors: takai kk. Genes Dev. 2020 Oct 1;34(19-20):1392-1405. doi: 10.1101/gad.328575.119. Epub 2020 Sep 3. Genes Dev. 2020. PMID: 32883681 Free PMC article.
Structural variant evolution after telomere crisis.
Dewhurst SM, Yao X, Rosiene J, Tian H, Behr J, Bosco N, Takai KK, de Lange T, Imieliński M. Dewhurst SM, et al. Among authors: takai kk. Nat Commun. 2021 Apr 7;12(1):2093. doi: 10.1038/s41467-021-21933-7. Nat Commun. 2021. PMID: 33828097 Free PMC article.
17 results