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Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
Penning TD, Talley JJ, Bertenshaw SR, Carter JS, Collins PW, Docter S, Graneto MJ, Lee LF, Malecha JW, Miyashiro JM, Rogers RS, Rogier DJ, Yu SS, AndersonGD, Burton EG, Cogburn JN, Gregory SA, Koboldt CM, Perkins WE, Seibert K, Veenhuizen AW, Zhang YY, Isakson PC. Penning TD, et al. Among authors: talley jj. J Med Chem. 1997 Apr 25;40(9):1347-65. doi: 10.1021/jm960803q. J Med Chem. 1997. PMID: 9135032
Pharmacological analysis of cyclooxygenase-1 in inflammation.
Smith CJ, Zhang Y, Koboldt CM, Muhammad J, Zweifel BS, Shaffer A, Talley JJ, Masferrer JL, Seibert K, Isakson PC. Smith CJ, et al. Among authors: talley jj. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13313-8. doi: 10.1073/pnas.95.22.13313. Proc Natl Acad Sci U S A. 1998. PMID: 9789085 Free PMC article.
4,5-Diaryloxazole inhibitors of cyclooxygenase-2 (COX-2).
Talley JJ, Bertenshaw SR, Brown DL, Carter JS, Graneto MJ, Koboldt CM, Masferrer JL, Norman BH, Rogier DJ Jr, Zwwifel BS, Seibert K. Talley JJ, et al. Med Res Rev. 1999 May;19(3):199-208. doi: 10.1002/(sici)1098-1128(199905)19:3<199::aid-med1>3.0.co;2-7. Med Res Rev. 1999. PMID: 10232649 Review.
Mechanism of inhibition of novel COX-2 inhibitors.
Gierse J, Kurumbail R, Walker M, Hood B, Monahan J, Pawlitz J, Stegeman R, Stevens A, Kiefer J, Koboldt C, Moreland K, Rowlinson S, Marnett L, Pierce J, Carter J, Talley J, Isakson P, Seibert K. Gierse J, et al. Adv Exp Med Biol. 2002;507:365-9. doi: 10.1007/978-1-4615-0193-0_56. Adv Exp Med Biol. 2002. PMID: 12664611 No abstract available.
The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: the second clinical candidate having a shorter and favorable human half-life.
Wang JL, Limburg D, Graneto MJ, Springer J, Hamper JR, Liao S, Pawlitz JL, Kurumbail RG, Maziasz T, Talley JJ, Kiefer JR, Carter J. Wang JL, et al. Among authors: talley jj. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7159-63. doi: 10.1016/j.bmcl.2010.07.054. Epub 2010 Jul 24. Bioorg Med Chem Lett. 2010. PMID: 20709553
25 results