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Dendrimer-2PMPA selectively blocks upregulated microglial GCPII activity and improves cognition in a mouse model of multiple sclerosis.
Hollinger KR, Sharma A, Tallon C, Lovell L, Thomas AG, Zhu X, Wiseman R, Wu Y, Kambhampati SP, Liaw K, Sharma R, Rojas C, Rais R, Kannan S, Kannan RM, Slusher BS. Hollinger KR, et al. Among authors: tallon c. Nanotheranostics. 2022 Jan 1;6(2):126-142. doi: 10.7150/ntno.63158. eCollection 2022. Nanotheranostics. 2022. PMID: 34976589 Free PMC article.
Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer's Disease.
Šála M, Hollinger KR, Thomas AG, Dash RP, Tallon C, Veeravalli V, Lovell L, Kögler M, Hřebabecký H, Procházková E, Nešuta O, Donoghue A, Lam J, Rais R, Rojas C, Slusher BS, Nencka R. Šála M, et al. Among authors: tallon c. J Med Chem. 2020 Jun 11;63(11):6028-6056. doi: 10.1021/acs.jmedchem.0c00278. Epub 2020 May 27. J Med Chem. 2020. PMID: 32298582 Free PMC article.
Inhibition of neutral sphingomyelinase 2 reduces extracellular vesicle release from neurons, oligodendrocytes, and activated microglial cells following acute brain injury.
Tallon C, Picciolini S, Yoo SW, Thomas AG, Pal A, Alt J, Carlomagno C, Gualerzi A, Rais R, Haughey NJ, Bedoni M, Slusher BS. Tallon C, et al. Biochem Pharmacol. 2021 Dec;194:114796. doi: 10.1016/j.bcp.2021.114796. Epub 2021 Oct 20. Biochem Pharmacol. 2021. PMID: 34678224 Free PMC article.
Dendrimer-Conjugated nSMase2 Inhibitor Reduces Tau Propagation in Mice.
Tallon C, Bell BJ, Sharma A, Pal A, Malvankar MM, Thomas AG, Yoo SW, Hollinger KR, Coleman K, Wilkinson EL, Kannan S, Haughey NJ, Kannan RM, Rais R, Slusher BS. Tallon C, et al. Pharmaceutics. 2022 Sep 28;14(10):2066. doi: 10.3390/pharmaceutics14102066. Pharmaceutics. 2022. PMID: 36297501 Free PMC article.
Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug.
Rais R, Lemberg KM, Tenora L, Arwood ML, Pal A, Alt J, Wu Y, Lam J, Aguilar JMH, Zhao L, Peters DE, Tallon C, Pandey R, Thomas AG, Dash RP, Seiwert T, Majer P, Leone RD, Powell JD, Slusher BS. Rais R, et al. Among authors: tallon c. Sci Adv. 2022 Nov 18;8(46):eabq5925. doi: 10.1126/sciadv.abq5925. Epub 2022 Nov 16. Sci Adv. 2022. PMID: 36383674 Free PMC article.
60 results