Tanaka H - Search Results

1

4'-Ethynylstavudine (4'-Ed4T) has potent anti-HIV-1 activity with reduced toxicity and shows a unique activity profile against drug-resistant mutants.

Tanaka H, Haraguchi K, Kumamoto H, Baba M, Cheng YC. Tanaka H, et al. Antivir Chem Chemother. 2005;16(4):217-21. doi: 10.1177/095632020501600402. Antivir Chem Chemother. 2005. PMID: 16130520 Free article.

2

Simple entry to 3'-substituted analogues of anti-HIV agent stavudine based on an anionic O --> C stannyl migration.

Kumamoto H, Tanaka H. Kumamoto H, et al. Among authors: tanaka h. J Org Chem. 2002 May 31;67(11):3541-7. doi: 10.1021/jo0107958. J Org Chem. 2002. PMID: 12027663

3

Synthesis of a highly active new anti-HIV agent 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine.

Haraguchi K, Takeda S, Tanaka H, Nitanda T, Baba M, Dutschman GE, Cheng YC. Haraguchi K, et al. Among authors: tanaka h. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3775-7. doi: 10.1016/j.bmcl.2003.07.009. Bioorg Med Chem Lett. 2003. PMID: 14552777

4

Synthesis and anti-HIV activity of 4'-cyano-2',3'-didehydro-3'-deoxythymidine.

Haraguchi K, Itoh Y, Takeda S, Honma Y, Tanaka H, Nitanda T, Baba M, Dutschman GE, Cheng YC. Haraguchi K, et al. Among authors: tanaka h. Nucleosides Nucleotides Nucleic Acids. 2004;23(4):647-54. doi: 10.1081/NCN-120030721. Nucleosides Nucleotides Nucleic Acids. 2004. PMID: 15200028

5

Synthesis of (+/-)-4'-ethynyl and 4'-cyano carbocyclic analogues of stavudine (d4T).

Kumamoto H, Haraguchi K, Tanaka H, Nitanda T, Baba M, Dutschman GE, Cheng YC, Kato K. Kumamoto H, et al. Among authors: tanaka h. Nucleosides Nucleotides Nucleic Acids. 2005;24(2):73-83. doi: 10.1081/NCN-51900. Nucleosides Nucleotides Nucleic Acids. 2005. PMID: 15822615

6

Anti-human immunodeficiency virus type 1 activity and resistance profile of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine in vitro.

Nitanda T, Wang X, Kumamoto H, Haraguchi K, Tanaka H, Cheng YC, Baba M. Nitanda T, et al. Among authors: tanaka h. Antimicrob Agents Chemother. 2005 Aug;49(8):3355-60. doi: 10.1128/AAC.49.8.3355-3360.2005. Antimicrob Agents Chemother. 2005. PMID: 16048947 Free PMC article.

7

A new approach to the synthesis of 4'-carbon-substituted nucleosides: development of a highly active anti-HIV agent 2', 3'-didehydro-3'-deoxy-4'-ethynylthymidine.

Haraguchi K, Takeda S, Sumino M, Tanaka H, Dutschman GE, Cheng YC, Nitanda T, Baba M. Haraguchi K, et al. Among authors: tanaka h. Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):343-7. doi: 10.1081/ncn-200059774. Nucleosides Nucleotides Nucleic Acids. 2005. PMID: 16247949

8

Nucleophilic substitution at the 4'-position of nucleosides: new access to a promising anti-HIV agent 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine.

Haraguchi K, Sumino M, Tanaka H. Haraguchi K, et al. Among authors: tanaka h. J Org Chem. 2006 Jun 9;71(12):4433-8. doi: 10.1021/jo060194m. J Org Chem. 2006. PMID: 16749771

9

3'-Carbon-substituted pyrimidine nucleosides having a 2',3'-dideoxy and 2',3'-didehydro-2',3'-dideoxy structure: synthesis and antiviral evaluation.

Kumamoto H, Onuma S, Tanaka H, Dutschman GE, Cheng YC. Kumamoto H, et al. Among authors: tanaka h. Antivir Chem Chemother. 2006;17(4):225-34. doi: 10.1177/095632020601700406. Antivir Chem Chemother. 2006. PMID: 17066900 Free article.

10

Synthesis of carbocyclic analogues of 4'-ethynyl- and 4'-cyano-d4T.

Kumamoto H, Kato K, Haraguchi K, Tanaka H, Nitanda T, Baba M, Dutschman GE, Cheng YC. Kumamoto H, et al. Among authors: tanaka h. Nucleic Acids Symp Ser (Oxf). 2004;(48):41-2. doi: 10.1093/nass/48.1.41. Nucleic Acids Symp Ser (Oxf). 2004. PMID: 17150468

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