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(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors.
Chonan T, Oi T, Yamamoto D, Yashiro M, Wakasugi D, Tanaka H, Ohoka-Sugita A, Io F, Koretsune H, Hiratate A. Chonan T, et al. Among authors: tanaka h. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6645-8. doi: 10.1016/j.bmcl.2009.10.012. Epub 2009 Oct 8. Bioorg Med Chem Lett. 2009. PMID: 19853443
Discovery of novel (4-piperidinyl)-piperazines as potent and orally active acetyl-CoA carboxylase 1/2 non-selective inhibitors: F-Boc and triF-Boc groups are acid-stable bioisosteres for the Boc group.
Chonan T, Wakasugi D, Yamamoto D, Yashiro M, Oi T, Tanaka H, Ohoka-Sugita A, Io F, Koretsune H, Hiratate A. Chonan T, et al. Among authors: tanaka h. Bioorg Med Chem. 2011 Mar 1;19(5):1580-93. doi: 10.1016/j.bmc.2011.01.041. Epub 2011 Jan 27. Bioorg Med Chem. 2011. PMID: 21324704
Identification of 2-[2-(4-tert-Butylphenyl)ethyl]-N-[4-(3-cyclopentylpropyl)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide as an Orally Active MGAT2 Inhibitor.
Busujima T, Tanaka H, Iwakiri K, Shirasaki Y, Munetomo E, Saito M, Masuko A, Kitano K, Io F, Kato K, Kamigaso S, Nozoe A, Sato N. Busujima T, et al. Among authors: tanaka h. Chem Pharm Bull (Tokyo). 2016;64(3):228-38. doi: 10.1248/cpb.c15-00803. Chem Pharm Bull (Tokyo). 2016. PMID: 26936050 Free article.
Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition.
Kawamura M, Kobashi Y, Tanaka H, Bohno-Mikami A, Hamada M, Ito Y, Hirata T, Ohara H, Kojima N, Koretsune H, Gunji E, Fukunaga T, Inatani S, Hasegawa Y, Suzuki A, Takahashi T, Kakinuma H. Kawamura M, et al. Among authors: tanaka h. J Med Chem. 2022 Nov 10;65(21):14599-14613. doi: 10.1021/acs.jmedchem.2c01089. Epub 2022 Nov 1. J Med Chem. 2022. PMID: 36318660
Association of a Transitional Heart Failure Management Program With Readmission and End-of-Life Care in Rural Japan.
Kinugasa Y, Nakamura K, Hirai M, Manba M, Ishiga N, Sota T, Nakayama N, Ohta T, Kato M, Adachi T, Fukuki M, Hirota Y, Mizuta E, Mura E, Nozaka Y, Omodani H, Tanaka H, Tanaka Y, Watanabe I, Mikami M, Yamamoto K. Kinugasa Y, et al. Among authors: tanaka h. Circ Rep. 2024 Apr 20;6(5):168-177. doi: 10.1253/circrep.CR-24-0030. eCollection 2024 May 10. Circ Rep. 2024. PMID: 38736846 Free PMC article.
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