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Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation.
Tanaka S, Fukumoto Y, Nochioka K, Minami T, Kudo S, Shiba N, Takai Y, Williams CL, Liao JK, Shimokawa H. Tanaka S, et al. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1591-600. doi: 10.1161/ATVBAHA.112.300922. Epub 2013 May 2. Arterioscler Thromb Vasc Biol. 2013. PMID: 23640485 Free PMC article. Clinical Trial.
Rho-Kinase Inhibition During Early Cardiac Development Causes Arrhythmogenic Right Ventricular Cardiomyopathy in Mice.
Ellawindy A, Satoh K, Sunamura S, Kikuchi N, Suzuki K, Minami T, Ikeda S, Tanaka S, Shimizu T, Enkhjargal B, Miyata S, Taguchi Y, Handoh T, Kobayashi K, Kobayashi K, Nakayama K, Miura M, Shimokawa H. Ellawindy A, et al. Among authors: tanaka s. Arterioscler Thromb Vasc Biol. 2015 Oct;35(10):2172-84. doi: 10.1161/ATVBAHA.115.305872. Epub 2015 Aug 27. Arterioscler Thromb Vasc Biol. 2015. PMID: 26315406
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