Tang J - Search Results

1

Structure-based design of highly selective β-secretase inhibitors: synthesis, biological evaluation, and protein-ligand X-ray crystal structure.

Ghosh AK, Venkateswara Rao K, Yadav ND, Anderson DD, Gavande N, Huang X, Terzyan S, Tang J. Ghosh AK, et al. Among authors: tang j. J Med Chem. 2012 Nov 8;55(21):9195-207. doi: 10.1021/jm3008823. Epub 2012 Sep 6. J Med Chem. 2012. PMID: 22954357 Free PMC article.

2

Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase).

Ghosh AK, Devasamudram T, Hong L, DeZutter C, Xu X, Weerasena V, Koelsch G, Bilcer G, Tang J. Ghosh AK, et al. Among authors: tang j. Bioorg Med Chem Lett. 2005 Jan 3;15(1):15-20. doi: 10.1016/j.bmcl.2004.10.084. Bioorg Med Chem Lett. 2005. PMID: 15582402

3

Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors.

Ghosh AK, Kumaragurubaran N, Hong L, Lei H, Hussain KA, Liu CF, Devasamudram T, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J. Ghosh AK, et al. Among authors: tang j. J Am Chem Soc. 2006 Apr 26;128(16):5310-1. doi: 10.1021/ja058636j. J Am Chem Soc. 2006. PMID: 16620080 Free PMC article.

4

Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands.

Ghosh AK, Kumaragurubaran N, Hong L, Kulkarni SS, Xu X, Chang W, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J. Ghosh AK, et al. Among authors: tang j. J Med Chem. 2007 May 17;50(10):2399-407. doi: 10.1021/jm061338s. Epub 2007 Apr 14. J Med Chem. 2007. PMID: 17432843

5

Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation.

Ghosh AK, Kumaragurubaran N, Hong L, Kulkarni S, Xu X, Miller HB, Reddy DS, Weerasena V, Turner R, Chang W, Koelsch G, Tang J. Ghosh AK, et al. Among authors: tang j. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1031-6. doi: 10.1016/j.bmcl.2007.12.028. Epub 2008 Jan 3. Bioorg Med Chem Lett. 2008. PMID: 18180160 Free PMC article.

6

Memapsin 2 (beta-secretase) inhibitors: drug development.

Ghosh AK, Kumaragurubaran N, Hong L, Koelsh G, Tang J. Ghosh AK, et al. Among authors: tang j. Curr Alzheimer Res. 2008 Apr;5(2):121-31. doi: 10.2174/156720508783954730. Curr Alzheimer Res. 2008. PMID: 18393797 Review.

7

beta-Secretase as a therapeutic target for Alzheimer's disease.

Ghosh AK, Gemma S, Tang J. Ghosh AK, et al. Among authors: tang j. Neurotherapeutics. 2008 Jul;5(3):399-408. doi: 10.1016/j.nurt.2008.05.007. Neurotherapeutics. 2008. PMID: 18625451 Free PMC article. Review.

8

Design, synthesis, protein-ligand X-ray structure, and biological evaluation of a series of novel macrocyclic human immunodeficiency virus-1 protease inhibitors to combat drug resistance.

Ghosh AK, Kulkarni S, Anderson DD, Hong L, Baldridge A, Wang YF, Chumanevich AA, Kovalevsky AY, Tojo Y, Amano M, Koh Y, Tang J, Weber IT, Mitsuya H. Ghosh AK, et al. Among authors: tang j. J Med Chem. 2009 Dec 10;52(23):7689-705. doi: 10.1021/jm900695w. J Med Chem. 2009. PMID: 19746963 Free PMC article.

9

Developing β-secretase inhibitors for treatment of Alzheimer's disease.

Ghosh AK, Brindisi M, Tang J. Ghosh AK, et al. Among authors: tang j. J Neurochem. 2012 Jan;120 Suppl 1(Suppl 1):71-83. doi: 10.1111/j.1471-4159.2011.07476.x. Epub 2011 Nov 28. J Neurochem. 2012. PMID: 22122681 Free PMC article. Review.

10

Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent β-secretase inhibitors.

Ghosh AK, Pandey S, Gangarajula S, Kulkarni S, Xu X, Rao KV, Huang X, Tang J. Ghosh AK, et al. Among authors: tang j. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5460-5. doi: 10.1016/j.bmcl.2012.07.043. Epub 2012 Jul 20. Bioorg Med Chem Lett. 2012. PMID: 22863204 Free PMC article.

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