TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry.
Feng Z, Liu S, Su M, Song C, Lin C, Zhao F, Li Y, Zeng X, Zhu Y, Hou Y, Ren C, Zhang H, Yi P, Ji Y, Wang C, Li H, Ma M, Luo L, Li L.
Feng Z, et al.
Nat Commun. 2024 Mar 15;15(1):2371. doi: 10.1038/s41467-024-46720-y.
Nat Commun. 2024.
PMID: 38490996
Free PMC article.
The TANGO6 N- and C-terminal cytoplasmic fragments capture RNA polymerase II subunit B (RPB) 2 in the cis-Golgi during the G1 phase. COPI-docked TANGO6 carries RPB2 to the ER and then to the nucleus. Functional disruption of TANGO6 hinders the nuclear entry o …
The TANGO6 N- and C-terminal cytoplasmic fragments capture RNA polymerase II subunit B (RPB) 2 in the cis-Golgi during the G1 phase. …