Taub ME - Search Results

1

Mode of action and human relevance assessment of male CD-1 mouse renal adenocarcinoma associated with lifetime exposure to empagliflozin.

Phillips JA, Taub ME, Bogdanffy MS, Yuan J, Knight B, Smith JD, Ku WW. Phillips JA, et al. Among authors: taub me. J Appl Toxicol. 2022 Oct;42(10):1570-1584. doi: 10.1002/jat.4329. Epub 2022 Apr 18. J Appl Toxicol. 2022. PMID: 35393688

2

A Predominant Oxidative Renal Metabolite of Empagliflozin in Male Mice Is Cytotoxic in Mouse Renal Tubular Cells but not Genotoxic.

Smith JD, Huang Z, Escobar PA, Foppiano P, Maw H, Loging W, Yu H, Phillips JA, Taub M, Ku WW. Smith JD, et al. Int J Toxicol. 2017 Nov/Dec;36(6):440-448. doi: 10.1177/1091581817735090. Epub 2017 Nov 12. Int J Toxicol. 2017. PMID: 29130831

3

Sex-, Species-, and Tissue-Specific Metabolism of Empagliflozin in Male Mouse Kidney Forms an Unstable Hemiacetal Metabolite (M466/2) That Degrades to 4-Hydroxycrotonaldehyde, a Reactive and Cytotoxic Species.

Taub ME, Ludwig-Schwellinger E, Ishiguro N, Kishimoto W, Yu H, Wagner K, Tweedie D. Taub ME, et al. Chem Res Toxicol. 2015 Jan 20;28(1):103-15. doi: 10.1021/tx500380t. Epub 2015 Jan 5. Chem Res Toxicol. 2015. PMID: 25489797

4

N-Methylation of BI 187004 by Thiol S-Methyltransferase.

Maw HH, Zeng X, Campbell S, Taub ME, Teitelbaum AM. Maw HH, et al. Among authors: taub me. Drug Metab Dispos. 2018 Jun;46(6):770-778. doi: 10.1124/dmd.117.079764. Epub 2018 Mar 7. Drug Metab Dispos. 2018. PMID: 29514826

5

Prediction and Quantification of Hepatic Transporter-Mediated Uptake of Pitavastatin Utilizing a Combination of the Relative Activity Factor Approach and Mechanistic Modeling.

Mitra P, Weinheimer S, Michalewicz M, Taub ME. Mitra P, et al. Among authors: taub me. Drug Metab Dispos. 2018 Jul;46(7):953-963. doi: 10.1124/dmd.118.080614. Epub 2018 Apr 17. Drug Metab Dispos. 2018. PMID: 29666154

6

Digoxin is not a substrate for organic anion-transporting polypeptide transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a substrate for a sodium-dependent transporter expressed in HEK293 cells.

Taub ME, Mease K, Sane RS, Watson CA, Chen L, Ellens H, Hirakawa B, Reyner EL, Jani M, Lee CA. Taub ME, et al. Drug Metab Dispos. 2011 Nov;39(11):2093-102. doi: 10.1124/dmd.111.040816. Epub 2011 Aug 17. Drug Metab Dispos. 2011. PMID: 21849517

7

Bridging in vitro and in vivo metabolism and transport of faldaprevir in human using a novel cocultured human hepatocyte system, HepatoPac.

Ramsden D, Tweedie DJ, Chan TS, Taub ME, Li Y. Ramsden D, et al. Among authors: taub me. Drug Metab Dispos. 2014 Mar;42(3):394-406. doi: 10.1124/dmd.113.055897. Epub 2013 Dec 23. Drug Metab Dispos. 2014. PMID: 24366904

8

The Use of Transporter Probe Drug Cocktails for the Assessment of Transporter-Based Drug-Drug Interactions in a Clinical Setting-Proposal of a Four Component Transporter Cocktail.

Ebner T, Ishiguro N, Taub ME. Ebner T, et al. Among authors: taub me. J Pharm Sci. 2015 Sep;104(9):3220-8. doi: 10.1002/jps.24489. Epub 2015 May 15. J Pharm Sci. 2015. PMID: 25981193

9

Enzyme-transporter interplay in the formation and clearance of abundant metabolites of faldaprevir found in excreta but not in circulation.

Li Y, Zhou J, Ramsden D, Taub ME, O'Brien D, Xu J, Busacca CA, Gonnella N, Tweedie DJ. Li Y, et al. Among authors: taub me. Drug Metab Dispos. 2014 Mar;42(3):384-93. doi: 10.1124/dmd.113.055863. Epub 2013 Dec 17. Drug Metab Dispos. 2014. PMID: 24346834

10

Mechanisms underlying benign and reversible unconjugated hyperbilirubinemia observed with faldaprevir administration in hepatitis C virus patients.

Sane RS, Steinmann GG, Huang Q, Li Y, Podila L, Mease K, Olson S, Taub ME, Stern JO, Nehmiz G, Böcher WO, Asselah T, Tweedie D. Sane RS, et al. Among authors: taub me. J Pharmacol Exp Ther. 2014 Nov;351(2):403-12. doi: 10.1124/jpet.114.218081. Epub 2014 Sep 9. J Pharmacol Exp Ther. 2014. PMID: 25204339 Clinical Trial.

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