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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 6
1999 1
2000 6
2001 2
2002 3
2003 2
2004 1
2005 6
2006 4
2007 5
2008 8
2009 2
2010 5
2011 10
2012 13
2013 13
2014 15
2015 25
2016 21
2017 25
2018 20
2019 27
2020 23
2021 24
2022 27
2023 40
2024 12

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313 results

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Page 1
Novel TCF21(high) pericyte subpopulation promotes colorectal cancer metastasis by remodelling perivascular matrix.
Li X, Pan J, Liu T, Yin W, Miao Q, Zhao Z, Gao Y, Zheng W, Li H, Deng R, Huang D, Qiu S, Zhang Y, Qi Q, Deng L, Huang M, Tang PM, Cao Y, Chen M, Ye W, Zhang D. Li X, et al. Gut. 2023 Apr;72(4):710-721. doi: 10.1136/gutjnl-2022-327913. Epub 2022 Sep 7. Gut. 2023. PMID: 36805487 Free PMC article.
Pericyte-conditional Tcf21-knockout mice were constructed to investigate the effects of TCF21 in TPCs on CRC metastasis. ...Tcf21 depletion in TPCs mitigated perivascular ECM remodelling and CRCLM, whereas the coinjection of TCF21(high) TPCs and CRC ce …
Pericyte-conditional Tcf21-knockout mice were constructed to investigate the effects of TCF21 in TPCs on CRC metastasis. ... …
Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis.
Wirka RC, Wagh D, Paik DT, Pjanic M, Nguyen T, Miller CL, Kundu R, Nagao M, Coller J, Koyano TK, Fong R, Woo YJ, Liu B, Montgomery SB, Wu JC, Zhu K, Chang R, Alamprese M, Tallquist MD, Kim JB, Quertermous T. Wirka RC, et al. Nat Med. 2019 Aug;25(8):1280-1289. doi: 10.1038/s41591-019-0512-5. Epub 2019 Jul 29. Nat Med. 2019. PMID: 31359001 Free PMC article.
Moreover, TCF21 expression was strongly associated with SMC phenotypic modulation in diseased human coronary arteries, and higher levels of TCF21 expression were associated with decreased CAD risk in human CAD-relevant tissues. These results establish a protective r …
Moreover, TCF21 expression was strongly associated with SMC phenotypic modulation in diseased human coronary arteries, and higher lev …
Intrapericardial long non-coding RNA-Tcf21 antisense RNA inducing demethylation administration promotes cardiac repair.
Zhu D, Liu S, Huang K, Li J, Mei X, Li Z, Cheng K. Zhu D, et al. Eur Heart J. 2023 May 14;44(19):1748-1760. doi: 10.1093/eurheartj/ehad114. Eur Heart J. 2023. PMID: 36916305 Free PMC article.
LncRNA-Tcf21 antisense RNA inducing demethylation (TARID) that enriched in EVs was identified to up-regulate Tcf21 expression. ...CONCLUSION: This study identified Tcf21 as a critical target for improving cardiac fibrosis. Up-regulating Tcf21 by using …
LncRNA-Tcf21 antisense RNA inducing demethylation (TARID) that enriched in EVs was identified to up-regulate Tcf21 expression. …
TCF21: a critical transcription factor in health and cancer.
Ao X, Ding W, Zhang Y, Ding D, Liu Y. Ao X, et al. J Mol Med (Berl). 2020 Aug;98(8):1055-1068. doi: 10.1007/s00109-020-01934-7. Epub 2020 Jun 15. J Mol Med (Berl). 2020. PMID: 32542449 Review.
Transcription factor 21 (TCF21) is a member of the basic helix-loop-helix (bHLH) transcription factors that mediate cell fate and differentiation by orchestrating temporal and spatial gene expression during the development of various organs. ...Its function is mainly regul …
Transcription factor 21 (TCF21) is a member of the basic helix-loop-helix (bHLH) transcription factors that mediate cell fate and dif …
TCF21(+) mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice.
Shen YC, Shami AN, Moritz L, Larose H, Manske GL, Ma Q, Zheng X, Sukhwani M, Czerwinski M, Sultan C, Chen H, Gurczynski SJ, Spence JR, Orwig KE, Tallquist M, Li JZ, Hammoud SS. Shen YC, et al. Nat Commun. 2021 Jun 23;12(1):3876. doi: 10.1038/s41467-021-24130-8. Nat Commun. 2021. PMID: 34162856 Free PMC article.
Here, we characterize a recently identified mouse testis interstitial population expressing the transcription factor Tcf21. We found that TCF21(lin) cells are bipotential somatic progenitors present in fetal testis and ovary, maintain adult testis homeostasis during …
Here, we characterize a recently identified mouse testis interstitial population expressing the transcription factor Tcf21. We found …
TCF21: Flipping the Phenotypic Switch in SMC.
Xie Y, Martin KA. Xie Y, et al. Circ Res. 2020 Feb 14;126(4):530-532. doi: 10.1161/CIRCRESAHA.120.316533. Epub 2020 Feb 13. Circ Res. 2020. PMID: 32078454 Free PMC article. No abstract available.
DNMT3a-mediated methylation of TCF21/hnRNPA1 aggravates hepatic fibrosis by regulating the NF-kappaB signaling pathway.
Li L, Diao S, Chen Z, Zhang J, Chen W, Wang T, Chen X, Zhao Y, Xu T, Huang C, Li J. Li L, et al. Pharmacol Res. 2023 Jul;193:106808. doi: 10.1016/j.phrs.2023.106808. Epub 2023 Jun 1. Pharmacol Res. 2023. PMID: 37268177 Free article.
However, the mechanism by which TCF21 regulates epithelial-mesenchymal transformation in hepatic fibrosis has not been elucidated. ...Furthermore, the combination of DNMT3a with TCF21 promoter results in TCF21 hypermethylation. Our results suggest that DNMT3a …
However, the mechanism by which TCF21 regulates epithelial-mesenchymal transformation in hepatic fibrosis has not been elucidated. .. …
Role of the bHLH transcription factor TCF21 in development and tumorigenesis.
Lotfi CFP, Passaia BS, Kremer JL. Lotfi CFP, et al. Braz J Med Biol Res. 2021 Mar 15;54(5):e10637. doi: 10.1590/1414-431X202010637. eCollection 2021. Braz J Med Biol Res. 2021. PMID: 33729392 Free PMC article. Review.
We summarize the molecular and biological properties of TCF21 control with an emphasis on molecular and functional TCF21 interactions. ...This review focuses on research on the roles of TCF21 in development and tumorigenesis systematically considering the phy …
We summarize the molecular and biological properties of TCF21 control with an emphasis on molecular and functional TCF21 inter …
The Tcf21 lineage constitutes the lung lipofibroblast population.
Park J, Ivey MJ, Deana Y, Riggsbee KL, Sörensen E, Schwabl V, Sjöberg C, Hjertberg T, Park GY, Swonger JM, Rosengreen T, Morty RE, Ahlbrecht K, Tallquist MD. Park J, et al. Am J Physiol Lung Cell Mol Physiol. 2019 May 1;316(5):L872-L885. doi: 10.1152/ajplung.00254.2018. Epub 2019 Jan 24. Am J Physiol Lung Cell Mol Physiol. 2019. PMID: 30675802 Free PMC article.
Others have demonstrated that Tcf21 is expressed in embryonic lung mesenchyme and that loss of Tcf21 results in a pulmonary hypoplasia phenotype. ...Lipid metabolism genes were highly expressed in perinatal and adult Tcf21 lineage cells. Overexpression of …
Others have demonstrated that Tcf21 is expressed in embryonic lung mesenchyme and that loss of Tcf21 results in a pulmonary hy …
Tcf21 marks visceral adipose mesenchymal progenitors and functions as a rate-limiting factor during visceral adipose tissue development.
Liu Q, Li C, Deng B, Gao P, Wang L, Li Y, Shiri M, Alkaifi F, Zhao J, Stephens JM, Simintiras CA, Francis J, Sun J, Fu X. Liu Q, et al. Cell Rep. 2023 Mar 28;42(3):112166. doi: 10.1016/j.celrep.2023.112166. Epub 2023 Feb 28. Cell Rep. 2023. PMID: 36857185 Free PMC article.
During development, the Tcf21 lineage gives rise to adipocytes. In adult mice, Tcf21 LCs transform into a fibrotic or quiescent state. ...Furthermore, single-cell RNA sequencing (scRNA-seq) identifies the heterogeneity of Tcf21 LCs. Loss of Tcf21 promo …
During development, the Tcf21 lineage gives rise to adipocytes. In adult mice, Tcf21 LCs transform into a fibrotic or quiescen …
313 results