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Characteristics of the TDRD1 gene promoter in chickens.
Gao X, Sun X, Xu P, Shi X, Zhang M, Yuan X, Jiang J, Jin K, Zuo Q, Zhang Y, Li B. Gao X, et al. Mol Genet Genomics. 2022 May;297(3):903-910. doi: 10.1007/s00438-022-01886-2. Epub 2022 Mar 28. Mol Genet Genomics. 2022. PMID: 35347417
Further, ChIP experiments verified that TCF7L2 enriched in the TDRD1 core transcriptional initiation region, suggesting that TCF7L2 and ZEB1 play an important role in the regulation of TDRD1. In summary, the region from - 161 to 0 bp is the core promoter region of …
Further, ChIP experiments verified that TCF7L2 enriched in the TDRD1 core transcriptional initiation region, suggesting that TCF7L2 a …
The cancer testis antigen TDRD1 regulates prostate cancer proliferation by associating with the snRNP biogenesis machinery.
Kim H, Barua A, Huang L, Zhou T, Bolaji M, Zachariah S, Mitra A, Jung SY, He B, Feng Q. Kim H, et al. Oncogene. 2023 Jun;42(22):1821-1831. doi: 10.1038/s41388-023-02690-x. Epub 2023 Apr 12. Oncogene. 2023. PMID: 37041411
In the nucleus, TDRD1 interacts with Coilin, the scaffold protein of Cajal bodies. ...Taken together, this study represents the first characterization of TDRD1 functions in prostate cancer development and suggests TDRD1 as a potential therapeutic target for p …
In the nucleus, TDRD1 interacts with Coilin, the scaffold protein of Cajal bodies. ...Taken together, this study represents the first …
DNA hypomethylation activation Wnt/TCF7L2/TDRD1 pathway promotes spermatogonial stem cell formation.
Gao X, Shi X, Zhou S, Chen C, Hu C, Xia Q, Li X, Gao W, Ding Y, Zuo Q, Zhang Y, Li B. Gao X, et al. J Cell Physiol. 2022 Sep;237(9):3640-3650. doi: 10.1002/jcp.30822. Epub 2022 Jul 5. J Cell Physiol. 2022. PMID: 35790000
Here, we predicted the target gene of the Wnt/TCF7L2 pathway, namely TDRD1, by bioinformatics analysis. Functional studies revealed that overexpression of TDRD1 during RA-induced SSCs formation in vitro significantly upregulated the expression of reproductive marker …
Here, we predicted the target gene of the Wnt/TCF7L2 pathway, namely TDRD1, by bioinformatics analysis. Functional studies revealed t …
The cancer testis antigen TDRD1 regulates prostate cancer proliferation by associating with snRNP biogenesis machinery.
Feng Q, Kim H, Barua A, Huang L, Bolaji M, Zachariah S, Jung SY, He B, Zhou T, Mitra A. Feng Q, et al. Res Sq [Preprint]. 2023 Feb 22:rs.3.rs-2035901. doi: 10.21203/rs.3.rs-2035901/v1. Res Sq. 2023. PMID: 36865141 Free PMC article. Updated. Preprint.
In the nucleus, TDRD1 interacts with Coilin, the scaffold protein of Cajal bodies. ...Taken together, this study represents the first characterization of TDRD1 functions in prostate cancer development and suggests TDRD1 as a potential therapeutic target for p …
In the nucleus, TDRD1 interacts with Coilin, the scaffold protein of Cajal bodies. ...Taken together, this study represents the first …
Tdrd1 acts as a molecular scaffold for Piwi proteins and piRNA targets in zebrafish.
Huang HY, Houwing S, Kaaij LJ, Meppelink A, Redl S, Gauci S, Vos H, Draper BW, Moens CB, Burgering BM, Ladurner P, Krijgsveld J, Berezikov E, Ketting RF. Huang HY, et al. EMBO J. 2011 Jul 8;30(16):3298-308. doi: 10.1038/emboj.2011.228. EMBO J. 2011. PMID: 21743441 Free PMC article.
Furthermore, we find that Tdrd1 binds both zebrafish Piwi proteins, Ziwi and Zili, and reveals sequence specificity in the interaction between Tdrd1 tudor domains and symmetrically dimethylated arginines (sDMAs) in Zili. Finally, we show that Tdrd1 complexes …
Furthermore, we find that Tdrd1 binds both zebrafish Piwi proteins, Ziwi and Zili, and reveals sequence specificity in the interactio …
Testicular expression of TDRD1, TDRD5, TDRD9 and TDRD12 in azoospermia.
Babakhanzadeh E, Khodadadian A, Rostami S, Alipourfard I, Aghaei M, Nazari M, Hosseinnia M, Mehrjardi MYV, Jamshidi Y, Ghasemi N. Babakhanzadeh E, et al. BMC Med Genet. 2020 Feb 14;21(1):33. doi: 10.1186/s12881-020-0970-0. BMC Med Genet. 2020. PMID: 32059713 Free PMC article.
METHODS: Here we evaluate gene and protein expression levels of four key TDRDs (TDRD1, TDRD5, TDRD9 and TDRD12) in testicular biopsy samples obtained from men with obstructive azoospermia (OA, n = 29), as controls, and various types of non-obstructive azoospermia containin …
METHODS: Here we evaluate gene and protein expression levels of four key TDRDs (TDRD1, TDRD5, TDRD9 and TDRD12) in testicular biopsy …
H3K4me2 cooperates with Wnt/TCF7L2 to regulate TDRD1 and promote chicken spermatogonia stem cell formation.
Ding Y, Gao X, Zhao J, Zhi Q, Liu X, Zuo Q, Jin K, Zhang Y, Niu Y, Han W, Song J, Li B. Ding Y, et al. Poult Sci. 2023 Apr;102(4):102552. doi: 10.1016/j.psj.2023.102552. Epub 2023 Feb 2. Poult Sci. 2023. PMID: 36921513 Free PMC article.
Functionally, RT-qPCR, flow cytometry, immunohistochemistry, and indirect immunofluorescence results showed that H3K4me2 regulated TDRD1 to promote SSCs formation both in vivo and in vitro. Furthermore, ChIP-qPCR and dual luciferase assays showed that H3K4me2 was enriched …
Functionally, RT-qPCR, flow cytometry, immunohistochemistry, and indirect immunofluorescence results showed that H3K4me2 regulated TDRD1 …
tdrd1 is a germline-specific and sexually dimorphically expressed gene in Paralichthys olivaceus.
Zhao J, Wang B, Yu H, Wang Y, Liu X, Zhang Q. Zhao J, et al. Gene. 2018 Oct 5;673:61-69. doi: 10.1016/j.gene.2018.06.043. Epub 2018 Jun 18. Gene. 2018. PMID: 29920365
Tudor domain containing protein 1 (tdrd1) is a member of the Tudor family and has shown essential functions during embryogenesis and gametogenesis. In this study, we cloned the full length cDNA of Paralichthys olivaceus tdrd1 (Potdrd1). PoTDRD1 is a multidomain prot …
Tudor domain containing protein 1 (tdrd1) is a member of the Tudor family and has shown essential functions during embryogenesis and …
Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell differentiation and nuage/germinal granule formation in mice.
Chuma S, Hosokawa M, Kitamura K, Kasai S, Fujioka M, Hiyoshi M, Takamune K, Noce T, Nakatsuji N. Chuma S, et al. Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15894-9. doi: 10.1073/pnas.0601878103. Epub 2006 Oct 12. Proc Natl Acad Sci U S A. 2006. PMID: 17038506 Free PMC article.
We report here that a targeted mutation in Tudor domain containing 1/mouse tudor repeat 1 (Tdrd1/Mtr-1), a tudor-related gene in mice, leads to male sterility because of postnatal spermatogenic defects. ...Tdrd1/Mtr-1 mutants lack, and Mvh/Ddx4 mutants show, strong …
We report here that a targeted mutation in Tudor domain containing 1/mouse tudor repeat 1 (Tdrd1/Mtr-1), a tudor-related gene in mice …
Upregulation of TDRD1 Promotes the Sexual Maturation in Allotetraploids Hybridized from Red Crucian Carp (Carassius auratus Red var) () and Common Carp (Cyprinus carpio L) ().
Yan Y, Wang Y, Wang J, Ren L, Dong X, Zhang C, Zeng Y, Liu S. Yan Y, et al. J Proteome Res. 2020 Jun 5;19(6):2337-2345. doi: 10.1021/acs.jproteome.0c00008. Epub 2020 Apr 28. J Proteome Res. 2020. PMID: 32286072
Protein-protein interaction and pathway analysis further suggested that TDRD1 served as a hub protein in metabolic-related pathways and networks. ...Quantitative proteomics integrated with network analysis explored the molecular mechanism in that TDRD1 regulated sex …
Protein-protein interaction and pathway analysis further suggested that TDRD1 served as a hub protein in metabolic-related pathways a …
85 results