Tulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafish.
Jia D, Gao P, Lv Y, Huang Y, Reilly J, Sun K, Han Y, Hu H, Chen X, Zhang Z, Li P, Luo J, Shu X, Tang Z, Liu F, Liu M, Ren X.
Jia D, et al.
Cell Death Dis. 2022 Nov 17;13(11):962. doi: 10.1038/s41419-022-05372-w.
Cell Death Dis. 2022.
PMID: 36396940
Free PMC article.
Photoreceptor cilium length was significantly reduced in the tulp1-dKO retinas. RNA-seq analysis showed that the expression of tektin2 (tekt2), a ciliary and flagellar microtubule structural component, was downregulated in the tulp1-dKO zebrafish. ...In conclusion, our stu …
Photoreceptor cilium length was significantly reduced in the tulp1-dKO retinas. RNA-seq analysis showed that the expression of tektin2 (t …