Tempel W - Search Results

1

Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product.

Hughes SJ, Barnard L, Mottaghi K, Tempel W, Antoshchenko T, Hong BS, Allali-Hassani A, Smil D, Vedadi M, Strauss E, Park HW. Hughes SJ, et al. Among authors: tempel w. ACS Infect Dis. 2016 Sep 9;2(9):627-641. doi: 10.1021/acsinfecdis.6b00090. Epub 2016 Aug 3. ACS Infect Dis. 2016. PMID: 27759386

2

Crystal structures of Klebsiella pneumoniae pantothenate kinase in complex with N-substituted pantothenamides.

Li B, Tempel W, Smil D, Bolshan Y, Schapira M, Park HW. Li B, et al. Among authors: tempel w. Proteins. 2013 Aug;81(8):1466-72. doi: 10.1002/prot.24290. Epub 2013 Jul 2. Proteins. 2013. PMID: 23553820

3

Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.

Hong BS, Allali-Hassani A, Tempel W, Finerty PJ Jr, Mackenzie F, Dimov S, Vedadi M, Park HW. Hong BS, et al. Among authors: tempel w. J Biol Chem. 2010 May 21;285(21):16330-40. doi: 10.1074/jbc.M109.039024. Epub 2010 Mar 18. J Biol Chem. 2010. PMID: 20299452 Free PMC article.

4

Structural characterization of human cholesterol 7α-hydroxylase.

Tempel W, Grabovec I, MacKenzie F, Dichenko YV, Usanov SA, Gilep AA, Park HW, Strushkevich N. Tempel W, et al. J Lipid Res. 2014 Sep;55(9):1925-32. doi: 10.1194/jlr.M050765. Epub 2014 Jun 13. J Lipid Res. 2014. PMID: 24927729 Free PMC article.

5

Chromokinesins NOD and KID Use Distinct ATPase Mechanisms and Microtubule Interactions To Perform a Similar Function.

Walker BC, Tempel W, Zhu H, Park H, Cochran JC. Walker BC, et al. Among authors: tempel w. Biochemistry. 2019 May 7;58(18):2326-2338. doi: 10.1021/acs.biochem.9b00011. Epub 2019 Apr 24. Biochemistry. 2019. PMID: 30973712

6

Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.

Butler KV, Ma A, Yu W, Li F, Tempel W, Babault N, Pittella-Silva F, Shao J, Wang J, Luo M, Vedadi M, Brown PJ, Arrowsmith CH, Jin J. Butler KV, et al. Among authors: tempel w. J Med Chem. 2016 Nov 10;59(21):9881-9889. doi: 10.1021/acs.jmedchem.6b01244. Epub 2016 Nov 2. J Med Chem. 2016. PMID: 27804297 Free PMC article.

7

Bromo-deaza-SAH: a potent and selective DOT1L inhibitor.

Yu W, Smil D, Li F, Tempel W, Fedorov O, Nguyen KT, Bolshan Y, Al-Awar R, Knapp S, Arrowsmith CH, Vedadi M, Brown PJ, Schapira M. Yu W, et al. Among authors: tempel w. Bioorg Med Chem. 2013 Apr 1;21(7):1787-1794. doi: 10.1016/j.bmc.2013.01.049. Epub 2013 Jan 30. Bioorg Med Chem. 2013. PMID: 23433670 Free PMC article.

8

Crystal structure of human multiple copies in T-cell lymphoma-1 oncoprotein.

Tempel W, Dimov S, Tong Y, Park HW, Hong BS. Tempel W, et al. Proteins. 2013 Mar;81(3):519-25. doi: 10.1002/prot.24198. Epub 2012 Dec 24. Proteins. 2013. PMID: 23042581

9

New small molecule inhibitors of histone methyl transferase DOT1L with a nitrile as a non-traditional replacement for heavy halogen atoms.

Spurr SS, Bayle ED, Yu W, Li F, Tempel W, Vedadi M, Schapira M, Fish PV. Spurr SS, et al. Among authors: tempel w. Bioorg Med Chem Lett. 2016 Sep 15;26(18):4518-4522. doi: 10.1016/j.bmcl.2016.07.041. Epub 2016 Jul 21. Bioorg Med Chem Lett. 2016. PMID: 27485386

10

Certhrax toxin, an anthrax-related ADP-ribosyltransferase from Bacillus cereus.

Visschedyk D, Rochon A, Tempel W, Dimov S, Park HW, Merrill AR. Visschedyk D, et al. Among authors: tempel w. J Biol Chem. 2012 Nov 30;287(49):41089-102. doi: 10.1074/jbc.M112.412809. Epub 2012 Sep 19. J Biol Chem. 2012. PMID: 22992735 Free PMC article.

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