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3,041 results

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The function and regulation of TET2 in innate immunity and inflammation.
Cong B, Zhang Q, Cao X. Cong B, et al. Protein Cell. 2021 Mar;12(3):165-173. doi: 10.1007/s13238-020-00796-6. Epub 2020 Oct 21. Protein Cell. 2021. PMID: 33085059 Free PMC article. Review.
Mutation and dysregulation of TET2 contribute to the development of multiple hematological malignancies. ...In addition, we highlight regulation of TET2 at various molecular levels as well as the correlated inflammatory diseases, which will provide the insight to in …
Mutation and dysregulation of TET2 contribute to the development of multiple hematological malignancies. ...In addition, we highlight …
TET2 regulates osteoclastogenesis by modulating autophagy in OVX-induced bone loss.
Yang C, Tao H, Zhang H, Xia Y, Bai J, Ge G, Li W, Zhang W, Xiao L, Xu Y, Wang Z, Gu Y, Yang H, Liu Y, Geng D. Yang C, et al. Autophagy. 2022 Dec;18(12):2817-2829. doi: 10.1080/15548627.2022.2048432. Epub 2022 Mar 24. Autophagy. 2022. PMID: 35255774 Free PMC article.
Macroautophagy/autophagy maintains cellular homeostasis by recycling unnecessary and damaged organelles. This study revealed that TET2 promoted bone loss in oophorectomized (OVX) mice and that TET2 promoted osteoclast differentiation by regulating autophagy. Tet2 …
Macroautophagy/autophagy maintains cellular homeostasis by recycling unnecessary and damaged organelles. This study revealed that TET2 …
Tet2 at the interface between cancer and immunity.
Jiang S. Jiang S. Commun Biol. 2020 Nov 12;3(1):667. doi: 10.1038/s42003-020-01391-5. Commun Biol. 2020. PMID: 33184433 Free PMC article. Review.
Tet2 mutations drive tumorigenesis in several blood cancers as well as in solid cancers. ...Finally, I propose key unanswered hypotheses regarding Tet2 in the cancer-immunity cycle....
Tet2 mutations drive tumorigenesis in several blood cancers as well as in solid cancers. ...Finally, I propose key unanswered hypothe …
Aging drives Tet2+/- clonal hematopoiesis via IL-1 signaling.
Caiado F, Kovtonyuk LV, Gonullu NG, Fullin J, Boettcher S, Manz MG. Caiado F, et al. Blood. 2023 Feb 23;141(8):886-903. doi: 10.1182/blood.2022016835. Blood. 2023. PMID: 36379023 Free PMC article.
Using bone marrow (BM) transplantation and newly developed genetic mosaicism (HSC-SCL-Cre-ERT; Tet2+/flox; R26+/tm6[CAG-ZsGreen1]Hze) mouse models of Tet2+/-driven CHIP, we observed an association between increased Tet2+/- clonal expansion and higher BM level …
Using bone marrow (BM) transplantation and newly developed genetic mosaicism (HSC-SCL-Cre-ERT; Tet2+/flox; R26+/tm6[CAG-ZsGreen1]Hze) …
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation.
Moran-Crusio K, Reavie L, Shih A, Abdel-Wahab O, Ndiaye-Lobry D, Lobry C, Figueroa ME, Vasanthakumar A, Patel J, Zhao X, Perna F, Pandey S, Madzo J, Song C, Dai Q, He C, Ibrahim S, Beran M, Zavadil J, Nimer SD, Melnick A, Godley LA, Aifantis I, Levine RL. Moran-Crusio K, et al. Cancer Cell. 2011 Jul 12;20(1):11-24. doi: 10.1016/j.ccr.2011.06.001. Epub 2011 Jun 30. Cancer Cell. 2011. PMID: 21723200 Free PMC article.
Although there are extensive genetic data implicating TET2 mutations in myeloid transformation, the consequences of Tet2 loss in hematopoietic development have not been delineated. ...In addition, Tet2(+/-) mice also displayed increased stem cell self-renewal …
Although there are extensive genetic data implicating TET2 mutations in myeloid transformation, the consequences of Tet2 loss …
Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.
Cimmino L, Dolgalev I, Wang Y, Yoshimi A, Martin GH, Wang J, Ng V, Xia B, Witkowski MT, Mitchell-Flack M, Grillo I, Bakogianni S, Ndiaye-Lobry D, Martín MT, Guillamot M, Banh RS, Xu M, Figueroa ME, Dickins RA, Abdel-Wahab O, Park CY, Tsirigos A, Neel BG, Aifantis I. Cimmino L, et al. Cell. 2017 Sep 7;170(6):1079-1095.e20. doi: 10.1016/j.cell.2017.07.032. Epub 2017 Aug 17. Cell. 2017. PMID: 28823558 Free PMC article.
To determine the role of TET2 deficiency in leukemia stem cell maintenance, we generated a reversible transgenic RNAi mouse to model restoration of endogenous Tet2 expression. Tet2 restoration reverses aberrant hematopoietic stem and progenitor cell (HSPC) se …
To determine the role of TET2 deficiency in leukemia stem cell maintenance, we generated a reversible transgenic RNAi mouse to model …
TET2 Suppresses VHL Deficiency-Driven Clear Cell Renal Cell Carcinoma by Inhibiting HIF Signaling.
Zhang X, Li S, He J, Jin Y, Zhang R, Dong W, Lin M, Yang Y, Tian T, Zhou Y, Xu Y, Lei QY, Zhang J, Zhang Q, Xu Y, Lv L. Zhang X, et al. Cancer Res. 2022 Jun 6;82(11):2097-2109. doi: 10.1158/0008-5472.CAN-21-3013. Cancer Res. 2022. PMID: 35176127
Stimulating the TET2-FBP1 axis with vitamin C repressed the growth of VHL-deficient ccRCC with wild-type TET2 and increased the sensitivity to glycolysis inhibitors. Moreover, combined expression levels of the HNF4alpha-TET2-FBP1 axis served as a biomarker of …
Stimulating the TET2-FBP1 axis with vitamin C repressed the growth of VHL-deficient ccRCC with wild-type TET2 and increased th …
Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils.
Huerga Encabo H, Aramburu IV, Garcia-Albornoz M, Piganeau M, Wood H, Song A, Ferrelli A, Sharma A, Minutti CM, Domart MC, Papazoglou D, Gurashi K, Llorian Sopena M, Goldstone R, Fallesen T, Wang Q, Ariza-McNaughton L, Wiseman DH, Batta K, Gupta R, Papayannopoulos V, Bonnet D. Huerga Encabo H, et al. Cell Stem Cell. 2023 Jun 1;30(6):781-799.e9. doi: 10.1016/j.stem.2023.05.004. Cell Stem Cell. 2023. PMID: 37267914 Free article.
Using genetic engineering of human HSCs (hHSCs) and transplantation in immunodeficient mice, we describe how a commonly mutated gene in CH, TET2, affects human neutrophil development and function. TET2 loss in hHSCs produce a distinct neutrophil heterogeneity in bon …
Using genetic engineering of human HSCs (hHSCs) and transplantation in immunodeficient mice, we describe how a commonly mutated gene in CH, …
JAK2 and TET2 Mutation in Polycythemia Vera.
Padda J, Khalid K, Yadav J, Almanie AH, Mehta KA, Al Hennawi H, Boddeti NL, Campos VYM, Jean-Charles G. Padda J, et al. Cureus. 2021 Sep 9;13(9):e17854. doi: 10.7759/cureus.17854. eCollection 2021 Sep. Cureus. 2021. PMID: 34660059 Free PMC article. Review.
The Ten-Eleven Translocation-2 (TET2) gene, located on chromosome 4q24, has been implicated in hematological malignancies. ...However, little is known about the role of TET2 mutations in patients with PV. Several studies have been conducted to further assess the sig …
The Ten-Eleven Translocation-2 (TET2) gene, located on chromosome 4q24, has been implicated in hematological malignancies. ...However …
TET2: A cornerstone in normal and malignant hematopoiesis.
Kunimoto H, Nakajima H. Kunimoto H, et al. Cancer Sci. 2021 Jan;112(1):31-40. doi: 10.1111/cas.14688. Epub 2020 Nov 18. Cancer Sci. 2021. PMID: 33048426 Free PMC article. Review.
TET2 itself associates with histone modifiers, thereby regulating histone modifications and expression of target genes. ...Future studies focusing on the molecular basis of stem cell and immune regulation by TET2 loss will further deepen our understanding of the ent …
TET2 itself associates with histone modifiers, thereby regulating histone modifications and expression of target genes. ...Future stu …
3,041 results