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2,021 results

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Page 1
TFEB at a glance.
Napolitano G, Ballabio A. Napolitano G, et al. J Cell Sci. 2016 Jul 1;129(13):2475-81. doi: 10.1242/jcs.146365. Epub 2016 Jun 1. J Cell Sci. 2016. PMID: 27252382 Free PMC article. Review.
Phosphorylated TFEB is retained in the cytoplasm, whereas dephosphorylated TFEB translocates to the nucleus to induce the transcription of target genes. Thus, a lysosome-to-nucleus signaling pathway regulates cellular energy metabolism through TFEB. Recently, …
Phosphorylated TFEB is retained in the cytoplasm, whereas dephosphorylated TFEB translocates to the nucleus to induce the tran …
TFEB; Beyond Its Role as an Autophagy and Lysosomes Regulator.
Franco-Juárez B, Coronel-Cruz C, Hernández-Ochoa B, Gómez-Manzo S, Cárdenas-Rodríguez N, Arreguin-Espinosa R, Bandala C, Canseco-Ávila LM, Ortega-Cuellar D. Franco-Juárez B, et al. Cells. 2022 Oct 7;11(19):3153. doi: 10.3390/cells11193153. Cells. 2022. PMID: 36231114 Free PMC article. Review.
The regulation of TFEB occurs predominantly at the post-translational level, including phosphorylation, acetylation, SUMOylating, PARsylation, and glycosylation. ...In this review, we provide updated insights into novel post-translational modifications that regulate TFE …
The regulation of TFEB occurs predominantly at the post-translational level, including phosphorylation, acetylation, SUMOylating, PAR …
Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.
Cui Z, Napolitano G, de Araujo MEG, Esposito A, Monfregola J, Huber LA, Ballabio A, Hurley JH. Cui Z, et al. Nature. 2023 Feb;614(7948):572-579. doi: 10.1038/s41586-022-05652-7. Epub 2023 Jan 25. Nature. 2023. PMID: 36697823 Free PMC article.
The transcription factor TFEB is a master regulator of lysosomal biogenesis and autophagy(1). ...Two full Rag-Ragulator complexes present each molecule of TFEB to the mTOR active site. One Rag-Ragulator complex is bound to Raptor in the canonical mode seen previousl …
The transcription factor TFEB is a master regulator of lysosomal biogenesis and autophagy(1). ...Two full Rag-Ragulator complexes pre …
Past, present, and future perspectives of transcription factor EB (TFEB): mechanisms of regulation and association with disease.
Tan A, Prasad R, Lee C, Jho EH. Tan A, et al. Cell Death Differ. 2022 Aug;29(8):1433-1449. doi: 10.1038/s41418-022-01028-6. Epub 2022 Jun 23. Cell Death Differ. 2022. PMID: 35739255 Free PMC article. Review.
This review also discusses the recently discovered regulatory mechanisms of TFEB and their implications for human diseases. We also summarize the moonlighting functions of TFEB and discuss future research directions and unanswered questions in the field. Overall, th …
This review also discusses the recently discovered regulatory mechanisms of TFEB and their implications for human diseases. We also s …
STUB1 regulates TFEB-induced autophagy-lysosome pathway.
Sha Y, Rao L, Settembre C, Ballabio A, Eissa NT. Sha Y, et al. EMBO J. 2017 Sep 1;36(17):2544-2552. doi: 10.15252/embj.201796699. Epub 2017 Jul 28. EMBO J. 2017. PMID: 28754656 Free PMC article.
Phosphorylated TFEB accumulated in STUB1-deficient cells and in tissues of STUB1-deficient mice resulting in reduced TFEB activity. Conversely, cellular overexpression of STUB1 resulted in reduced phosphorylated TFEB and increased TFEB activity. STUB1 …
Phosphorylated TFEB accumulated in STUB1-deficient cells and in tissues of STUB1-deficient mice resulting in reduced TFEB acti …
The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB Perspective.
Martini-Stoica H, Xu Y, Ballabio A, Zheng H. Martini-Stoica H, et al. Trends Neurosci. 2016 Apr;39(4):221-234. doi: 10.1016/j.tins.2016.02.002. Epub 2016 Mar 9. Trends Neurosci. 2016. PMID: 26968346 Free PMC article. Review.
Decades of research have therefore focused on enhancing the ALP in neurodegenerative diseases. More recently, transcription factor EB (TFEB), a major regulator of autophagy and lysosomal biogenesis, has emerged as a leading factor in addressing disease pathology. We review …
Decades of research have therefore focused on enhancing the ALP in neurodegenerative diseases. More recently, transcription factor EB (TF …
Regulation of TFEB nuclear localization by HSP90AA1 promotes autophagy and longevity.
Yang S, Nie T, She H, Tao K, Lu F, Hu Y, Huang L, Zhu L, Feng D, He D, Qi J, Kukar T, Ma L, Mao Z, Yang Q. Yang S, et al. Autophagy. 2023 Mar;19(3):822-838. doi: 10.1080/15548627.2022.2105561. Epub 2022 Aug 8. Autophagy. 2023. PMID: 35941759 Free PMC article.
However, the detailed mechanisms that regulate TFEB activity are not fully clear. In this study, we identified a role for HSP90AA1 in modulating TFEB. ...This phosphorylation inhibited HSP90AA1, disrupted its binding to TFEB, and impeded TFEB's nuclear …
However, the detailed mechanisms that regulate TFEB activity are not fully clear. In this study, we identified a role for HSP90AA1 in …
TFEB Biology and Agonists at a Glance.
Chen M, Dai Y, Liu S, Fan Y, Ding Z, Li D. Chen M, et al. Cells. 2021 Feb 5;10(2):333. doi: 10.3390/cells10020333. Cells. 2021. PMID: 33562649 Free PMC article. Review.
Recently, several TFEB agonists have been identified and preclinical or clinical trials are applied. In this review, we present an overview of the latest research on TFEB biology and TFEB agonists....
Recently, several TFEB agonists have been identified and preclinical or clinical trials are applied. In this review, we present an ov …
TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages.
Schuster EM, Epple MW, Glaser KM, Mihlan M, Lucht K, Zimmermann JA, Bremser A, Polyzou A, Obier N, Cabezas-Wallscheid N, Trompouki E, Ballabio A, Vogel J, Buescher JM, Westermann AJ, Rambold AS. Schuster EM, et al. Nat Metab. 2022 Jul;4(7):856-866. doi: 10.1038/s42255-022-00605-w. Epub 2022 Jul 21. Nat Metab. 2022. PMID: 35864246 Free PMC article.
Here we identify the lysosomal biogenesis factor transcription factor EB (TFEB) as regulator for phago-lysosome-mitochondria crosstalk in macrophages. ...By activating itaconate production, TFEB selectively restricts proliferating Salmonella, a bacterial subpopulati …
Here we identify the lysosomal biogenesis factor transcription factor EB (TFEB) as regulator for phago-lysosome-mitochondria crosstal …
TFEB-mediated lysosomal exocytosis alleviates high-fat diet-induced lipotoxicity in the kidney.
Nakamura J, Yamamoto T, Takabatake Y, Namba-Hamano T, Minami S, Takahashi A, Matsuda J, Sakai S, Yonishi H, Maeda S, Matsui S, Matsui I, Hamano T, Takahashi M, Goto M, Izumi Y, Bamba T, Sasai M, Yamamoto M, Matsusaka T, Niimura F, Yanagita M, Nakamura S, Yoshimori T, Ballabio A, Isaka Y. Nakamura J, et al. JCI Insight. 2023 Feb 22;8(4):e162498. doi: 10.1172/jci.insight.162498. JCI Insight. 2023. PMID: 36649084 Free PMC article.
Activated TFEB mediated lysosomal exocytosis of phospholipids, which helped reduce MLB accumulation in PTECs. ...These results indicate a critical role of TFEB-mediated lysosomal exocytosis in counteracting renal lipotoxicity....
Activated TFEB mediated lysosomal exocytosis of phospholipids, which helped reduce MLB accumulation in PTECs. ...These results indica …
2,021 results