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1987 1
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1996 3
1997 1
1998 3
1999 4
2001 3
2002 6
2003 4
2004 5
2005 5
2006 3
2007 1
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2013 3
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128 results

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Page 1
PIWI-Interacting RNA HAAPIR Regulates Cardiomyocyte Death After Myocardial Infarction by Promoting NAT10-Mediated ac(4) C Acetylation of Tfec mRNA.
Wang K, Zhou LY, Liu F, Lin L, Ju J, Tian PC, Liu CY, Li XM, Chen XZ, Wang T, Wang F, Wang SC, Zhang J, Zhang YH, Tian JW, Wang K. Wang K, et al. Adv Sci (Weinh). 2022 Mar;9(8):e2106058. doi: 10.1002/advs.202106058. Epub 2022 Feb 9. Adv Sci (Weinh). 2022. PMID: 35138696 Free PMC article.
Mechanistically, HAAPIR directly interacts with NAT10 and enhances ac(4) C acetylation of Tfec mRNA transcript, which increases Tfec expression. TFEC can further upregulate the transcription of BCL2-interacting killer (Bik), a pro-apoptotic factor, which resu …
Mechanistically, HAAPIR directly interacts with NAT10 and enhances ac(4) C acetylation of Tfec mRNA transcript, which increases Tf …
TFEC contributes to cardiac hypertrophy by inhibiting AMPK/mTOR signaling.
Zhao T, Wang Z, Chi Y, Ni C, Zheng X. Zhao T, et al. Exp Ther Med. 2021 Nov;22(5):1271. doi: 10.3892/etm.2021.10706. Epub 2021 Sep 7. Exp Ther Med. 2021. PMID: 34594408 Free PMC article.
Injection of rAd-short hairpin (sh)-TFEC significantly decreased the expression of TFEC in heart tissues compared with group injected with rAd-negative control (NC). ...In addition, the AngII-induced increase in cardiomyocyte size could be reversed by TFEC kn …
Injection of rAd-short hairpin (sh)-TFEC significantly decreased the expression of TFEC in heart tissues compared with group i …
On the role of TFEC in reptilian coloration.
Tzika AC. Tzika AC. Front Cell Dev Biol. 2024 Feb 7;12:1358828. doi: 10.3389/fcell.2024.1358828. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 38385026 Free PMC article.
Genomic mapping previously identified a TFEC mutation linked to the piebald ball python phenotype. The association of TFEC with skin coloration was further supported by gene-editing experiments in the brown anole lizard. ...Indeed, both wild-type and piebald ball py …
Genomic mapping previously identified a TFEC mutation linked to the piebald ball python phenotype. The association of TFEC wit …
tfec controls the hematopoietic stem cell vascular niche during zebrafish embryogenesis.
Mahony CB, Fish RJ, Pasche C, Bertrand JY. Mahony CB, et al. Blood. 2016 Sep 8;128(10):1336-45. doi: 10.1182/blood-2016-04-710137. Epub 2016 Jul 11. Blood. 2016. PMID: 27402973 Free article.
Tfec mediates these changes by increasing the expression of several cytokines in cECs from the CHT niche. Among these, we found kitlgb, which could rescue the loss of HSCs observed in tfec mutants. We conclude that tfec plays an important role in the niche to …
Tfec mediates these changes by increasing the expression of several cytokines in cECs from the CHT niche. Among these, we found kitlg …
The complex relationship between TFEB transcription factor phosphorylation and subcellular localization.
Puertollano R, Ferguson SM, Brugarolas J, Ballabio A. Puertollano R, et al. EMBO J. 2018 Jun 1;37(11):e98804. doi: 10.15252/embj.201798804. Epub 2018 May 15. EMBO J. 2018. PMID: 29764979 Free PMC article. Review.
The MiT-TFE family of basic helix-loop-helix leucine-zipper transcription factors includes four members: TFEB, TFE3, TFEC, and MITF Originally described as oncogenes, these factors play a major role as regulators of lysosome biogenesis, cellular energy homeostasis, and aut …
The MiT-TFE family of basic helix-loop-helix leucine-zipper transcription factors includes four members: TFEB, TFE3, TFEC, and MITF O …
The MITF paralog tfec is required in neural crest development for fate specification of the iridophore lineage from a multipotent pigment cell progenitor.
Petratou K, Spencer SA, Kelsh RN, Lister JA. Petratou K, et al. PLoS One. 2021 Jan 13;16(1):e0244794. doi: 10.1371/journal.pone.0244794. eCollection 2021. PLoS One. 2021. PMID: 33439865 Free PMC article.
Mitfa has been identified as the master regulator of melanocyte fate. Here, we show that an Mitf-related transcription factor, Tfec, functions as master regulator of the iridophore fate. Surprisingly, our phenotypic analysis of tfec mutants demonstrates that Tfec …
Mitfa has been identified as the master regulator of melanocyte fate. Here, we show that an Mitf-related transcription factor, Tfec, …
TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation.
Zhao GQ, Zhao Q, Zhou X, Mattei MG, de Crombrugghe B. Zhao GQ, et al. Mol Cell Biol. 1993 Aug;13(8):4505-12. doi: 10.1128/mcb.13.8.4505-4512.1993. Mol Cell Biol. 1993. PMID: 8336698 Free PMC article.
TFEC RNA is found in many tissues of adult rats, but the relative concentrations of TFEC and TFE3 RNAs vary considerably in these different tissues. No TFEC RNA was detectable in several cell lines, including fibroblasts, myoblasts, chondrosarcoma cells, and …
TFEC RNA is found in many tissues of adult rats, but the relative concentrations of TFEC and TFE3 RNAs vary considerably in th …
Piebaldism and chromatophore development in reptiles are linked to the tfec gene.
Garcia-Elfring A, Sabin CE, Iouchmanov AL, Roffey HL, Samudra SP, Alcala AJ, Osman RS, Lauderdale JD, Hendry AP, Menke DB, Barrett RDH. Garcia-Elfring A, et al. Curr Biol. 2023 Feb 27;33(4):755-763.e3. doi: 10.1016/j.cub.2023.01.004. Epub 2023 Jan 25. Curr Biol. 2023. PMID: 36702128 Free PMC article.
We functionally validated tfec in a lizard model (Anolis sagrei) using the gene editing CRISPR/Cas9 system and TEM imaging of skin. Our findings show that reading frame mutations in tfec affect coloration and lead to a loss of iridophores in Anolis, indicating that …
We functionally validated tfec in a lizard model (Anolis sagrei) using the gene editing CRISPR/Cas9 system and TEM imaging of skin. O …
TFEC can function as a transcriptional activator of the nonmuscle myosin II heavy chain-A gene in transfected cells.
Chung MC, Kim HK, Kawamoto S. Chung MC, et al. Biochemistry. 2001 Jul 31;40(30):8887-97. doi: 10.1021/bi002847d. Biochemistry. 2001. PMID: 11467950
Furthermore, cDNA cloning by polymerase chain reaction yielded cDNAs for two TFEC isoforms, designated TFEC-l and TFEC-s, which are generated by alternative pre-mRNA splicing. ...TFE3 has a high transactivation potency but the lowest binding activity. TFEC …
Furthermore, cDNA cloning by polymerase chain reaction yielded cDNAs for two TFEC isoforms, designated TFEC-l and TFEC- …
TFEC is a macrophage-restricted member of the microphthalmia-TFE subfamily of basic helix-loop-helix leucine zipper transcription factors.
Rehli M, Lichanska A, Cassady AI, Ostrowski MC, Hume DA. Rehli M, et al. J Immunol. 1999 Feb 1;162(3):1559-65. J Immunol. 1999. PMID: 9973413
The murine homologue of the TFEC was cloned as part of an analysis of the expression of the microphthalmia-TFE (MiT) subfamily of transcription factors in macrophages. ...Five of six putative Ets motifs identified in the TFEC promoter bind the macrophage-restricted …
The murine homologue of the TFEC was cloned as part of an analysis of the expression of the microphthalmia-TFE (MiT) subfamily of tra …
128 results