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Year Number of Results
1994 3
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2000 6
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2002 7
2003 16
2004 11
2005 12
2006 12
2007 15
2008 18
2009 19
2010 21
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399 results

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Page 1
Kunitz-type protease inhibitor TFPI2 remodels stemness and immunosuppressive tumor microenvironment in glioblastoma.
Pang L, Dunterman M, Guo S, Khan F, Liu Y, Taefi E, Bahrami A, Geula C, Hsu WH, Horbinski C, James CD, Chen P. Pang L, et al. Nat Immunol. 2023 Oct;24(10):1654-1670. doi: 10.1038/s41590-023-01605-y. Epub 2023 Sep 4. Nat Immunol. 2023. PMID: 37667051
In human GBM, TFPI2 correlates positively with stemness, microglia abundance, immunosuppression and poor prognosis. Our study identifies a function for TFPI2 and supports therapeutic targeting of TFPI2 as an effective strategy for GBM....
In human GBM, TFPI2 correlates positively with stemness, microglia abundance, immunosuppression and poor prognosis. Our study identif …
TFPI2 suppresses breast cancer progression through inhibiting TWIST-integrin alpha5 pathway.
Zhao D, Qiao J, He H, Song J, Zhao S, Yu J. Zhao D, et al. Mol Med. 2020 Apr 5;26(1):27. doi: 10.1186/s10020-020-00158-2. Mol Med. 2020. PMID: 32248791 Free PMC article.
Over-expression of TFPI2 inhibited cell viability, proliferation, migration and invasion of breast cancer cells. Mechanistically, Twist-related protein 1 (TWIST1) was negatively associated with TFPI2 in breast cancer patients, whose expression was decreased by TF …
Over-expression of TFPI2 inhibited cell viability, proliferation, migration and invasion of breast cancer cells. Mechanistically, Twi …
The TFPI2-PPARgamma axis induces M2 polarization and inhibits fibroblast activation to promote recovery from post-myocardial infarction in diabetic mice.
Guo M, Xia Z, Hong Y, Ji H, Li F, Liu W, Li S, Xin H, Tan K, Lian Z. Guo M, et al. J Inflamm (Lond). 2023 Nov 1;20(1):35. doi: 10.1186/s12950-023-00357-8. J Inflamm (Lond). 2023. PMID: 37915070 Free PMC article.
Therefore, in the present study, we investigated the role of TFPI2 in post-MI effects in a diabetic mouse model. RESULTS: TFPI2 expression was markedly decreased in the infarcted myocardium of diabetic MI mice compared with that in non-diabetic mice. ...TFPI2 …
Therefore, in the present study, we investigated the role of TFPI2 in post-MI effects in a diabetic mouse model. RESULTS: TFPI2 …
TFPI2 Promotes Perivascular Migration in an Angiotropism Model of Melanoma.
Mo J, Zhao X, Wang W, Zhao N, Dong X, Zhang Y, Cheng R, Sun B. Mo J, et al. Front Oncol. 2021 Jun 24;11:662434. doi: 10.3389/fonc.2021.662434. eCollection 2021. Front Oncol. 2021. PMID: 34249699 Free PMC article.
Angiotropism and TFPI2 expression were examined in surgical specimens of melanoma by immunohistochemical staining. ...High levels of TFPI2 were correlated with worse and better survival in uveal and cutaneous melanoma, respectively. ...
Angiotropism and TFPI2 expression were examined in surgical specimens of melanoma by immunohistochemical staining. ...High levels of …
TFPI2 suppresses the interaction of TGF-beta2 pathway regulators to promote endothelial-mesenchymal transition in diabetic nephropathy.
Guan G, Xie J, Dai Y, Han H. Guan G, et al. J Biol Chem. 2022 Mar;298(3):101725. doi: 10.1016/j.jbc.2022.101725. Epub 2022 Feb 11. J Biol Chem. 2022. PMID: 35157852 Free PMC article.
Here, we found abnormal upregulation of TFPI2 in the renal cortex of diabetic mice, accompanied by impaired renal function. We also injected a single dose of adeno-associated virus (AAV)2 carrying shRNA targeting TFPI2 intravenously into these mice and found that kn …
Here, we found abnormal upregulation of TFPI2 in the renal cortex of diabetic mice, accompanied by impaired renal function. We also i …
Two ways of epigenetic silencing of TFPI2 in cervical cancer.
Fullár A, Karászi K, Hollósi P, Lendvai G, Oláh L, Reszegi A, Papp Z, Sobel G, Dudás J, Kovalszky I. Fullár A, et al. PLoS One. 2020 Jun 19;15(6):e0234873. doi: 10.1371/journal.pone.0234873. eCollection 2020. PLoS One. 2020. PMID: 32559232 Free PMC article.
Due to downregulation of miR-23a expression by HPV in cancer cells, TFPI2 was silenced by promoter methylation. In contrary, miR-23a was active in HPV-free fibroblasts and inactivated TFPI2. ...As a consequence, inactivation of the TFPI2 gene plays a strategi …
Due to downregulation of miR-23a expression by HPV in cancer cells, TFPI2 was silenced by promoter methylation. In contrary, miR-23a …
Gene methylation in gastric cancer.
Qu Y, Dang S, Hou P. Qu Y, et al. Clin Chim Acta. 2013 Sep 23;424:53-65. doi: 10.1016/j.cca.2013.05.002. Epub 2013 May 10. Clin Chim Acta. 2013. PMID: 23669186 Free article. Review.
The role of TFPI2 hypermethylation in the detection of gastric and colorectal cancer.
Hu H, Chen X, Wang C, Jiang Y, Li J, Ying X, Yang Y, Li B, Zhou C, Zhong J, Wu D, Ying J, Duan S. Hu H, et al. Oncotarget. 2017 Sep 20;8(48):84054-84065. doi: 10.18632/oncotarget.21097. eCollection 2017 Oct 13. Oncotarget. 2017. PMID: 29137404 Free PMC article.
Similarly, TCGA data also supported TFPI2 hypermethylation was a promising diagnostic marker for GC and CRC. ...In conclusion, TFPI2 hypermethylation might be a promising diagnostic biomarker for GC and CRC....
Similarly, TCGA data also supported TFPI2 hypermethylation was a promising diagnostic marker for GC and CRC. ...In conclusion, TFP …
SDC2 and TFPI2 Methylation in Stool Samples as an Integrated Biomarker for Early Detection of Colorectal Cancer.
Zhang W, Yang C, Wang S, Xiang Z, Dou R, Lin Z, Zheng J, Xiong B. Zhang W, et al. Cancer Manag Res. 2021 Apr 30;13:3601-3617. doi: 10.2147/CMAR.S300861. eCollection 2021. Cancer Manag Res. 2021. PMID: 33958894 Free PMC article.
Moreover, SDC2 and TFPI2 methylation showed a positive correlation. Functional network analysis suggested that both methylated SDC2 and TFPI2 were involved in tumor cells' metabolic programs. ...CONCLUSION: Our data indicate that SDC2 and TFPI2 were hypermeth …
Moreover, SDC2 and TFPI2 methylation showed a positive correlation. Functional network analysis suggested that both methylated SDC2 a …
399 results