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The alveolar rhabdomyosarcoma PAX3/FKHR fusion protein is a transcriptional activator.
Sublett JE, Jeon IS, Shapiro DN. Sublett JE, et al. Oncogene. 1995 Aug 3;11(3):545-52. Oncogene. 1995. PMID: 7630639
The PAX3/FKHR fusion gene, formed by a t(2;13)(q35;q14) in alveolar rhabdomyosarcoma, encodes a hybrid protein that contains both PAX3 DNA binding domains, the paired box and homeodomain, linked to the bisected DNA binding domain of FKHR, …
The PAX3/FKHR fusion gene, formed by a t(2;13)(q35;q14) in alveolar rhabdomyosarcoma, encodes a hybrid …
The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3.
Fredericks WJ, Galili N, Mukhopadhyay S, Rovera G, Bennicelli J, Barr FG, Rauscher FJ 3rd. Fredericks WJ, et al. Mol Cell Biol. 1995 Mar;15(3):1522-35. doi: 10.1128/MCB.15.3.1522. Mol Cell Biol. 1995. PMID: 7862145 Free PMC article.
To determine the role of the fusion protein in transcriptional regulation and oncogenesis, we identified the PAX3-FKHR fusion protein and characterized its function(s) as a transcription factor relative to wild-type PAX3. .. …
To determine the role of the fusion protein in transcriptional regulation and oncogenesis, we identified the PAX3 …
The PAX3-FOXO1 fusion protein present in rhabdomyosarcoma interferes with normal FOXO activity and the TGF-beta pathway.
Schmitt-Ney M, Camussi G. Schmitt-Ney M, et al. PLoS One. 2015 Mar 25;10(3):e0121474. doi: 10.1371/journal.pone.0121474. eCollection 2015. PLoS One. 2015. PMID: 25806826 Free PMC article.
PAX3-FOXO1 (PAX3-FKHR) is the fusion protein produced by the genomic translocation that characterizes the alveolar subtype of Rhabdomyosarcoma, a pediatric sarcoma with myogenic phenotype. PAX3-FOXO1 is an aberrant but functional trans …
PAX3-FOXO1 (PAX3-FKHR) is the fusion protein produced by the genomic translocation that characterizes the alv …
The hybrid PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma transforms fibroblasts in culture.
Scheidler S, Fredericks WJ, Rauscher FJ 3rd, Barr FG, Vogt PK. Scheidler S, et al. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9805-9. doi: 10.1073/pnas.93.18.9805. Proc Natl Acad Sci U S A. 1996. PMID: 8790412 Free PMC article.
The PAX3-FKHR fusion product retains the DNA binding domains of the PAX3 protein and the putative activator domain of the FKHR protein. The PAX3-FKHR protein has been shown to function as a transcriptional a …
The PAX3-FKHR fusion product retains the DNA binding domains of the PAX3 protein and the putative activator …
Structural and functional studies of FKHR-PAX3, a reciprocal fusion gene of the t(2;13) chromosomal translocation in alveolar rhabdomyosarcoma.
Hu Q, Yuan Y, Wang C. Hu Q, et al. PLoS One. 2013 Jun 14;8(6):e68065. doi: 10.1371/journal.pone.0068065. Print 2013. PLoS One. 2013. PMID: 23799156 Free PMC article.
Alveolar rhabdomyosarcoma (ARMS) is an aggressive pediatric cancer of skeletal muscle. More than 70% of ARMS tumors carry balanced t(2;13) chromosomal translocation that leads to the production of two novel fusion genes, PAX3-FKHR and FKHR-PAX3. …
Alveolar rhabdomyosarcoma (ARMS) is an aggressive pediatric cancer of skeletal muscle. More than 70% of ARMS tumors carry bala …
Alveolar rhabdomyosarcoma-associated proteins PAX3/FOXO1A and PAX7/FOXO1A suppress the transcriptional activity of MyoD-target genes in muscle stem cells.
Calhabeu F, Hayashi S, Morgan JE, Relaix F, Zammit PS. Calhabeu F, et al. Oncogene. 2013 Jan 31;32(5):651-62. doi: 10.1038/onc.2012.73. Epub 2012 Jun 18. Oncogene. 2013. PMID: 22710712
Rhabdomyosarcoma (RMS) is the commonest soft-tissue sarcoma in childhood and is characterized by expression of myogenic proteins, including the transcription factors MyoD and myogenin. ...PAX3/FOXO1A or PAX7/FOXO1A did not inhibit the transcriptional …
Rhabdomyosarcoma (RMS) is the commonest soft-tissue sarcoma in childhood and is characterized by expression of myogenic proteins …
PAX3-FKHR sensitizes human alveolar rhabdomyosarcoma cells to camptothecin-mediated growth inhibition and apoptosis.
Zeng FY, Cui J, Liu L, Chen T. Zeng FY, et al. Cancer Lett. 2009 Nov 1;284(2):157-64. doi: 10.1016/j.canlet.2009.04.016. Epub 2009 May 12. Cancer Lett. 2009. PMID: 19442434 Free PMC article.
Patients with alveolar rhabdomyosarcoma (ARMS) have poorer response to conventional chemotherapy and lower survival rates than those with embryonal RMS (ERMS). ...Camptothecin more efficiently inhibited proliferation and induced apoptosis in Rh30 (ARMS) than RD (ERM …
Patients with alveolar rhabdomyosarcoma (ARMS) have poorer response to conventional chemotherapy and lower survival rates than …
Carnitine palmitoyltransferase 1A (CPT1A): a transcriptional target of PAX3-FKHR and mediates PAX3-FKHR-dependent motility in alveolar rhabdomyosarcoma cells.
Liu L, Wang YD, Wu J, Cui J, Chen T. Liu L, et al. BMC Cancer. 2012 Apr 25;12:154. doi: 10.1186/1471-2407-12-154. BMC Cancer. 2012. PMID: 22533991 Free PMC article.
More than 80% of aggressive ARMSs harbor a PAX3-FKHR fusion transcription factor, which regulates cell migration and promotes metastasis, most likely by regulating the fusion protein's transcriptional targets. ...We showed t …
More than 80% of aggressive ARMSs harbor a PAX3-FKHR fusion transcription factor, which regulates cell migration …
In vivo amplification of the PAX3-FKHR and PAX7-FKHR fusion genes in alveolar rhabdomyosarcoma.
Barr FG, Nauta LE, Davis RJ, Schäfer BW, Nycum LM, Biegel JA. Barr FG, et al. Hum Mol Genet. 1996 Jan;5(1):15-21. doi: 10.1093/hmg/5.1.15. Hum Mol Genet. 1996. PMID: 8789435 Free article.
In the pediatric cancer alveolar rhabdomyosarcoma, characteristic t(2;13)(q35;q14) or variant t(1;13)(p36;q14) chromosomal translocations generate PAX3-FKHR or PAX7-FKHR fusion genes. Using fluorescence in situ hybridization, reverse transcripta …
In the pediatric cancer alveolar rhabdomyosarcoma, characteristic t(2;13)(q35;q14) or variant t(1;13)(p36;q14) chromosomal tra …
Lack of effective T-lymphocyte response to the PAX3/FKHR translocation area in alveolar rhabdomyosarcoma.
Rodeberg DA, Nuss RA, Heppelmann CJ, Celis E. Rodeberg DA, et al. Cancer Immunol Immunother. 2005 Jun;54(6):526-34. doi: 10.1007/s00262-004-0625-6. Epub 2004 Nov 20. Cancer Immunol Immunother. 2005. PMID: 15838707 Free PMC article.
PURPOSE: Alveolar rhabdomyosarcoma (ARMS) frequently contains the fusion transcription factor PAX3/FKHR. ...CONCLUSIONS: It appears that the fusion area of PAX3/FKHR may not be a good source of antigenic anti-tumor pe …
PURPOSE: Alveolar rhabdomyosarcoma (ARMS) frequently contains the fusion transcription factor PAX3/FKH …
49 results