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2000 1
2022 5
2023 3
2024 1

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THEM6-mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer.
Blomme A, Peter C, Mui E, Rodriguez Blanco G, An N, Mason LM, Jamieson LE, McGregor GH, Lilla S, Ntala C, Patel R, Thiry M, Kung SHY, Leclercq M, Ford CA, Rushworth LK, McGarry DJ, Mason S, Repiscak P, Nixon C, Salji MJ, Markert E, MacKay GM, Kamphorst JJ, Graham D, Faulds K, Fazli L, Gleave ME, Avezov E, Edwards J, Yin H, Sumpton D, Blyth K, Close P, Murphy DJ, Zanivan S, Leung HY. Blomme A, et al. EMBO Mol Med. 2022 Mar 7;14(3):e14764. doi: 10.15252/emmm.202114764. Epub 2022 Jan 11. EMBO Mol Med. 2022. PMID: 35014179 Free PMC article.
In this study, we identified thioesterase superfamily member 6 (THEM6) as a marker of ADT resistance in PCa. THEM6 deletion reduces in vivo tumour growth and restores castration sensitivity in orthograft models of CRPC. ...Altogether, our results highlight THEM6 …
In this study, we identified thioesterase superfamily member 6 (THEM6) as a marker of ADT resistance in PCa. THEM6 deletion re …
THEM6: A Novel Molecular Biomarker Predicts Tumor Microenvironment, Molecular Subtype, and Prognosis in Bladder Cancer.
Zhao X, Hu J, Li J, Gu L, Chen J, Othmane B, Gong G, Yuan J, Deng H. Zhao X, et al. Dis Markers. 2022 Jul 21;2022:7147279. doi: 10.1155/2022/7147279. eCollection 2022. Dis Markers. 2022. PMID: 35909893 Free PMC article.
While THEM6 high expression indicated luminal subtype, hyperprogression and better response to targeted therapies, such as blocking THEM6 and several immune-inhibited oncogenic pathways. ...THEM6 could accurately predict the molecular subtype of BLCA, which w …
While THEM6 high expression indicated luminal subtype, hyperprogression and better response to targeted therapies, such as blocking …
THEM6 is a prognostic biomarker for breast cancer and is associated with immune infiltration.
Lu X, Chen W, Tian G, Ge F. Lu X, et al. Sci Rep. 2023 Dec 11;13(1):21974. doi: 10.1038/s41598-023-49379-5. Sci Rep. 2023. PMID: 38081884 Free PMC article.
Biological functional analyses revealed that THEM6 was associated with tumor progression and pathogenesis. Finally, we discovered that in BRCA, THEM6 expression was linked to multiple immune cell types. qRT-PCR and Western blotting experiments demonstrated a general …
Biological functional analyses revealed that THEM6 was associated with tumor progression and pathogenesis. Finally, we discovered tha …
Identification of immune-related prognostic biomarkers in triple-negative breast cancer.
Song XQ, Shao ZM. Song XQ, et al. Transl Cancer Res. 2024 Apr 30;13(4):1707-1720. doi: 10.21037/tcr-23-1554. Epub 2024 Apr 25. Transl Cancer Res. 2024. PMID: 38737702 Free PMC article.
RESULTS: The prognostic risk score model included 12 genes: TDO2, CHIT1, CARML2, HLA-C, ADIRF, C19orf33, CA8, AHNAK2, RHOV, OPLAH, THEM6, and NEBL. The receiver operator characteristic (ROC) curves for survivability values at 1, 3, and 5 years in the FUSCC TNBC cohort demo …
RESULTS: The prognostic risk score model included 12 genes: TDO2, CHIT1, CARML2, HLA-C, ADIRF, C19orf33, CA8, AHNAK2, RHOV, OPLAH, THEM6 …
Cell cycle protein BORA is associated with colorectal cancer progression by AURORA-PLK1 cascades: a bioinformatics analysis.
Mahajan M, Sarkar A, Mondal S. Mahajan M, et al. J Cell Commun Signal. 2023 Sep;17(3):773-791. doi: 10.1007/s12079-022-00719-6. Epub 2022 Dec 20. J Cell Commun Signal. 2023. PMID: 36538275 Free PMC article.
Six Sub-networks and seven key genes, BORA, CCT7, DTL, RUVBL1, RUVBL2, THEM6 and TMEM97 associated with the CRC progression were identified. ...
Six Sub-networks and seven key genes, BORA, CCT7, DTL, RUVBL1, RUVBL2, THEM6 and TMEM97 associated with the CRC progression were iden …
The First Pituitary Proteome Landscape From Matched Anterior and Posterior Lobes for a Better Understanding of the Pituitary Gland.
Banerjee A, Biswas D, Barpanda A, Halder A, Sibal S, Kattimani R, Shah A, Mahadevan A, Goel A, Srivastava S. Banerjee A, et al. Mol Cell Proteomics. 2023 Jan;22(1):100478. doi: 10.1016/j.mcpro.2022.100478. Epub 2022 Dec 5. Mol Cell Proteomics. 2023. PMID: 36470533 Free PMC article.
The study also identified proteins POU1F1 (pituitary-specific positive transcription factor 1), POMC (pro-opiomelanocortin), PCOLCE2 (procollagen C-endopeptidase enhancer 2), and NPTX2 (neuronal pentraxin-2) as pituitary-enriched proteins and was validated for their lobe specific …
The study also identified proteins POU1F1 (pituitary-specific positive transcription factor 1), POMC (pro-opiomelanocortin), PCOLCE2 (procol …