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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 4
1970 1
1979 1
1983 1
1991 1
1993 2
1994 1
1995 2
1996 2
1997 2
1998 2
1999 2
2000 7
2001 4
2002 6
2003 15
2004 9
2005 13
2006 8
2007 5
2008 8
2009 17
2010 9
2011 10
2012 10
2013 12
2014 24
2015 27
2016 28
2017 24
2018 18
2019 34
2020 40
2021 32
2022 44
2023 36
2024 18

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429 results

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Page 1
THEMIS: Two Models, Different Thresholds.
Choi S, Cornall R, Lesourne R, Love PE. Choi S, et al. Trends Immunol. 2017 Sep;38(9):622-632. doi: 10.1016/j.it.2017.06.006. Epub 2017 Jul 8. Trends Immunol. 2017. PMID: 28697966 Free PMC article. Review.
THEMIS, a recently identified T-lineage-restricted protein, is the founding member of a large metazoan protein family. Gene inactivation studies have revealed a critical requirement for THEMIS during thymocyte positive selection, implicating THEMIS in signali …
THEMIS, a recently identified T-lineage-restricted protein, is the founding member of a large metazoan protein family. Gene inactivat …
THEMIS: Justice Delayed.
Banerjee S, Rosol ZP. Banerjee S, et al. J Am Coll Cardiol. 2024 Apr 30;83(17):1637-1639. doi: 10.1016/j.jacc.2024.03.383. J Am Coll Cardiol. 2024. PMID: 38658102 No abstract available.
THEMIS: a critical TCR signal regulator for ligand discrimination.
Gascoigne NR, Acuto O. Gascoigne NR, et al. Curr Opin Immunol. 2015 Apr;33:86-92. doi: 10.1016/j.coi.2015.01.020. Epub 2015 Feb 18. Curr Opin Immunol. 2015. PMID: 25700024 Review.
However, its molecular role remained an enigma until recently. Conventionally positively-selected T-cells are lacking in THEMIS-deficient mice, leading to the initial hypothesis that THEMIS positively regulates TCR signaling. ...The finding that THEMIS is con …
However, its molecular role remained an enigma until recently. Conventionally positively-selected T-cells are lacking in THEMIS-defic …
Themis suppresses the effector function of CD8(+) T cells in acute viral infection.
Tang J, Jia X, Li J, Dong J, Wang J, Li W, Zhu Y, Hu Y, Hou B, Lin C, Cong Y, Ren T, Yan C, Yang H, Lai Q, Zheng H, Bao Y, Gautam N, Wang HR, Xu B, Chen XL, Li Q, Gascoigne NRJ, Fu G. Tang J, et al. Cell Mol Immunol. 2023 May;20(5):512-524. doi: 10.1038/s41423-023-00997-z. Epub 2023 Mar 28. Cell Mol Immunol. 2023. PMID: 36977779 Free PMC article.
Recent studies using Themis T-cell conditional knockout mice also demonstrated that Themis is required to promote mature CD8(+) T-cell homeostasis, cytokine responsiveness, and antibacterial responses. ...Mechanistically, we found that Themis mediates PD-1 ex …
Recent studies using Themis T-cell conditional knockout mice also demonstrated that Themis is required to promote mature CD8(+ …
Themis controls T cell activation, effector functions, and metabolism of peripheral CD8(+) T cells.
Gautam N, Wojciech L, Yap J, Chua YL, Ding EM, Sim DC, Tan AS, Ahl PJ, Prasad M, Tung DW, Connolly JE, Adriani G, Brzostek J, Gascoigne NR. Gautam N, et al. Life Sci Alliance. 2023 Sep 22;6(12):e202302156. doi: 10.26508/lsa.202302156. Print 2023 Dec. Life Sci Alliance. 2023. PMID: 37739454 Free PMC article.
Themis is important in regulating positive selection of thymocytes during T cell development, but its role in peripheral T cells is less understood. ...This study reveals the phenomenon of peripheral adaptation to loss of Themis, by demonstrating direct TCR-induced …
Themis is important in regulating positive selection of thymocytes during T cell development, but its role in peripheral T cells is l …
THEMIS increases TCR signaling in CD4(+)CD8(+) thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1.
Choi S, Lee J, Hatzihristidis T, Gaud G, Dutta A, Arya A, Clubb LM, Stamos DB, Markovics A, Mikecz K, Love PE. Choi S, et al. Sci Signal. 2023 May 9;16(784):eade1274. doi: 10.1126/scisignal.ade1274. Epub 2023 May 9. Sci Signal. 2023. PMID: 37159521 Free PMC article.
The T cell lineage-restricted protein THEMIS plays a critical role in T cell development at the positive selection stage. ...Moreover, overexpression of SHP1 phenocopied the Themis(-/-) developmental defect, whereas deletion of Ptpn6, Ptpn11 (encoding SHP2), or both …
The T cell lineage-restricted protein THEMIS plays a critical role in T cell development at the positive selection stage. ...Moreover …
THEMIS and THEMIS-PCI.
Bhatt DL, Steg PG. Bhatt DL, et al. Eur Heart J. 2019 Nov 1;40(41):3378-3381. doi: 10.1093/eurheartj/ehz707. Eur Heart J. 2019. PMID: 31545357 Clinical Trial. No abstract available.
Negative times negative equals positive, THEMIS sets the rule on thymic selection and peripheral T cell responses.
Mélique S, Yang C, Lesourne R. Mélique S, et al. Biomed J. 2022 Apr;45(2):334-346. doi: 10.1016/j.bj.2022.03.008. Epub 2022 Mar 26. Biomed J. 2022. PMID: 35346866 Free PMC article. Review.
Recent evidences also point to a role for THEMIS in peripheral T cells beyond its role on thymic selection. Here, we present an overview of the past research on THEMIS in the context of T cell development and peripheral T cell function and discuss the possible impli …
Recent evidences also point to a role for THEMIS in peripheral T cells beyond its role on thymic selection. Here, we present an overv …
Themis is indispensable for IL-2 and IL-15 signaling in T cells.
Liu Y, Cong Y, Niu Y, Yuan Y, Tan F, Lai Q, Hu Y, Hou B, Li J, Lin C, Zheng H, Dong J, Tang J, Chen Q, Brzostek J, Zhang X, Chen XL, Wang HR, Gascoigne NRJ, Xu B, Lin SH, Fu G. Liu Y, et al. Sci Signal. 2022 Feb 15;15(721):eabi9983. doi: 10.1126/scisignal.abi9983. Epub 2022 Feb 15. Sci Signal. 2022. PMID: 35167340
We investigated whether Themis plays a direct role in cytokine signaling in mature T cells. ...The cellular, metabolic, and biochemical defects caused by Themis deficiency were corrected in mice lacking both Themis and the phosphatase Shp1, suggesting that …
We investigated whether Themis plays a direct role in cytokine signaling in mature T cells. ...The cellular, metabolic, and biochemic …
THEMIS-tery is solved.
Wiest DL. Wiest DL. Nat Immunol. 2017 Mar 22;18(4):368-370. doi: 10.1038/ni.3708. Nat Immunol. 2017. PMID: 28323266 No abstract available.
429 results