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Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent.
Theoclitou ME, Aquila B, Block MH, Brassil PJ, Castriotta L, Code E, Collins MP, Davies AM, Deegan T, Ezhuthachan J, Filla S, Freed E, Hu H, Huszar D, Jayaraman M, Lawson D, Lewis PM, Nadella MV, Oza V, Padmanilayam M, Pontz T, Ronco L, Russell D, Whitston D, Zheng X. Theoclitou ME, et al. J Med Chem. 2011 Oct 13;54(19):6734-50. doi: 10.1021/jm200629m. Epub 2011 Sep 7. J Med Chem. 2011. PMID: 21899292
Kinesin motor proteins as targets for cancer therapy.
Huszar D, Theoclitou ME, Skolnik J, Herbst R. Huszar D, et al. Among authors: theoclitou me. Cancer Metastasis Rev. 2009 Jun;28(1-2):197-208. doi: 10.1007/s10555-009-9185-8. Cancer Metastasis Rev. 2009. PMID: 19156502 Review.
Role of Surface Perfection in Chemical Force Microscopy.
McKendry R, Theoclitou ME, Abell C, Rayment T. McKendry R, et al. Among authors: theoclitou me. Langmuir. 1998 May 12;14(10):2846-2849. doi: 10.1021/la970374e. Langmuir. 1998. PMID: 27690145