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Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways.
Deelen J, Uh HW, Monajemi R, van Heemst D, Thijssen PE, Böhringer S, van den Akker EB, de Craen AJ, Rivadeneira F, Uitterlinden AG, Westendorp RG, Goeman JJ, Slagboom PE, Houwing-Duistermaat JJ, Beekman M. Deelen J, et al. Among authors: thijssen pe. Age (Dordr). 2013 Feb;35(1):235-49. doi: 10.1007/s11357-011-9340-3. Epub 2011 Nov 24. Age (Dordr). 2013. PMID: 22113349 Free PMC article.
Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers.
Deelen J, Beekman M, Codd V, Trompet S, Broer L, Hägg S, Fischer K, Thijssen PE, Suchiman HE, Postmus I, Uitterlinden AG, Hofman A, de Craen AJ, Metspalu A, Pedersen NL, van Duijn CM, Jukema JW, Houwing-Duistermaat JJ, Samani NJ, Slagboom PE. Deelen J, et al. Among authors: thijssen pe. Int J Epidemiol. 2014 Jun;43(3):878-86. doi: 10.1093/ije/dyt267. Epub 2014 Jan 14. Int J Epidemiol. 2014. PMID: 24425829 Free PMC article.
Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies.
Pons D, Trompet S, de Craen AJ, Thijssen PE, Quax PH, de Vries MR, Wierda RJ, van den Elsen PJ, Monraats PS, Ewing MM, Heijmans BT, Slagboom PE, Zwinderman AH, Doevendans PA, Tio RA, de Winter RJ, de Maat MP, Iakoubova OA, Sattar N, Shepherd J, Westendorp RG, Jukema JW; PROSPER study group; WOSCOPS study group; GENDER study group. Pons D, et al. Among authors: thijssen pe. Heart. 2011 Jan;97(2):143-50. doi: 10.1136/hrt.2010.199927. Epub 2010 Nov 8. Heart. 2011. PMID: 21062767
DNA methylation signatures link prenatal famine exposure to growth and metabolism.
Tobi EW, Goeman JJ, Monajemi R, Gu H, Putter H, Zhang Y, Slieker RC, Stok AP, Thijssen PE, Müller F, van Zwet EW, Bock C, Meissner A, Lumey LH, Eline Slagboom P, Heijmans BT. Tobi EW, et al. Among authors: thijssen pe. Nat Commun. 2014 Nov 26;5:5592. doi: 10.1038/ncomms6592. Nat Commun. 2014. PMID: 25424739 Free PMC article.
Corrigendum: DNA methylation signatures link prenatal famine exposure to growth and metabolism.
Tobi EW, Goeman JJ, Monajemi R, Gu H, Putter H, Zhang Y, Slieker RC, Stok AP, Thijssen PE, Müller F, van Zwet EW, Bock C, Meissner A, Lumey LH, Eline Slagboom P, Heijmans BT. Tobi EW, et al. Among authors: thijssen pe. Nat Commun. 2015 Jul 7;6:7740. doi: 10.1038/ncomms8740. Nat Commun. 2015. PMID: 26151124 Free PMC article. No abstract available.
Heterogeneous clinical presentation in ICF syndrome: correlation with underlying gene defects.
Weemaes CM, van Tol MJ, Wang J, van Ostaijen-ten Dam MM, van Eggermond MC, Thijssen PE, Aytekin C, Brunetti-Pierri N, van der Burg M, Graham Davies E, Ferster A, Furthner D, Gimelli G, Gennery A, Kloeckener-Gruissem B, Meyn S, Powell C, Reisli I, Schuetz C, Schulz A, Shugar A, van den Elsen PJ, van der Maarel SM. Weemaes CM, et al. Among authors: thijssen pe. Eur J Hum Genet. 2013 Nov;21(11):1219-25. doi: 10.1038/ejhg.2013.40. Epub 2013 Mar 13. Eur J Hum Genet. 2013. PMID: 23486536 Free PMC article.
Adipocyte telomere length associates negatively with adipocyte size, whereas adipose tissue telomere length associates negatively with the extent of fibrosis in severely obese women.
el Bouazzaoui F, Henneman P, Thijssen P, Visser A, Koning F, Lips MA, Janssen I, Pijl H, Willems van Dijk K, van Harmelen V. el Bouazzaoui F, et al. Int J Obes (Lond). 2014 May;38(5):746-9. doi: 10.1038/ijo.2013.175. Epub 2013 Sep 12. Int J Obes (Lond). 2014. PMID: 24100424
Mutations in CDCA7 and HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome.
Thijssen PE, Ito Y, Grillo G, Wang J, Velasco G, Nitta H, Unoki M, Yoshihara M, Suyama M, Sun Y, Lemmers RJ, de Greef JC, Gennery A, Picco P, Kloeckener-Gruissem B, Güngör T, Reisli I, Picard C, Kebaili K, Roquelaure B, Iwai T, Kondo I, Kubota T, van Ostaijen-Ten Dam MM, van Tol MJ, Weemaes C, Francastel C, van der Maarel SM, Sasaki H. Thijssen PE, et al. Nat Commun. 2015 Jul 28;6:7870. doi: 10.1038/ncomms8870. Nat Commun. 2015. PMID: 26216346 Free PMC article.
25 results