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Probing a protein-protein interaction by in vitro evolution.
Thom G, Cockroft AC, Buchanan AG, Candotti CJ, Cohen ES, Lowne D, Monk P, Shorrock-Hart CP, Jermutus L, Minter RR. Thom G, et al. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7619-24. doi: 10.1073/pnas.0602341103. Epub 2006 May 9. Proc Natl Acad Sci U S A. 2006. PMID: 16684878 Free PMC article.
A variant human IgG1-Fc mediates improved ADCC.
Stewart R, Thom G, Levens M, Güler-Gane G, Holgate R, Rudd PM, Webster C, Jermutus L, Lund J. Stewart R, et al. Among authors: thom g. Protein Eng Des Sel. 2011 Sep;24(9):671-8. doi: 10.1093/protein/gzr015. Epub 2011 May 18. Protein Eng Des Sel. 2011. PMID: 21596686
Ribosome display.
Thom G, Groves M. Thom G, et al. Methods Mol Biol. 2012;901:101-16. doi: 10.1007/978-1-61779-931-0_6. Methods Mol Biol. 2012. PMID: 22723096
Brain penetration, target engagement, and disposition of the blood-brain barrier-crossing bispecific antibody antagonist of metabotropic glutamate receptor type 1.
Webster CI, Caram-Salas N, Haqqani AS, Thom G, Brown L, Rennie K, Yogi A, Costain W, Brunette E, Stanimirovic DB. Webster CI, et al. Among authors: thom g. FASEB J. 2016 May;30(5):1927-40. doi: 10.1096/fj.201500078. Epub 2016 Feb 2. FASEB J. 2016. PMID: 26839377
Central mGluR1 target engagement after systemic administration was demonstrated by a dose-dependent inhibition of mGluR-1-mediated thermal hyperalgesia and by colocalization of the antibody with thalamic neurons involved in mGluR1-mediated pain processing. We demonstrate the feas …
Central mGluR1 target engagement after systemic administration was demonstrated by a dose-dependent inhibition of mGluR-1-mediated thermal h …
97 results