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Reversible action of diaminothiazoles in cancer cells is implicated by the induction of a fast conformational change of tubulin and suppression of microtubule dynamics.
Thomas NE, Thamkachy R, Sivakumar KC, Sreedevi KJ, Louis XL, Thomas SA, Kumar R, Rajasekharan KN, Cassimeris L, Sengupta S. Thomas NE, et al. Among authors: thomas sa. Mol Cancer Ther. 2014 Jan;13(1):179-89. doi: 10.1158/1535-7163.MCT-13-0479. Epub 2013 Nov 5. Mol Cancer Ther. 2014. PMID: 24194566
Diaminothiazoles evade multidrug resistance in cancer cells and xenograft tumour models and develop transient specific resistance: understanding the basis of broad-spectrum versus specific resistance.
Vasudevan S, Thomas SA, Sivakumar KC, Komalam RJ, Sreerekha KV, Rajasekharan KN, Sengupta S. Vasudevan S, et al. Among authors: thomas sa. Carcinogenesis. 2015 Aug;36(8):883-93. doi: 10.1093/carcin/bgv072. Epub 2015 May 25. Carcinogenesis. 2015. PMID: 26014355
519 results