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How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop.
Kirkland D, Pfuhler S, Tweats D, Aardema M, Corvi R, Darroudi F, Elhajouji A, Glatt H, Hastwell P, Hayashi M, Kasper P, Kirchner S, Lynch A, Marzin D, Maurici D, Meunier JR, Müller L, Nohynek G, Parry J, Parry E, Thybaud V, Tice R, van Benthem J, Vanparys P, White P. Kirkland D, et al. Among authors: thybaud v. Mutat Res. 2007 Mar 30;628(1):31-55. doi: 10.1016/j.mrgentox.2006.11.008. Epub 2007 Jan 13. Mutat Res. 2007. PMID: 17293159
Strategies in case of positive in vivo results in genotoxicity testing.
Thybaud V, Macgregor JT, Müller L, Crebelli R, Dearfield K, Douglas G, Farmer PB, Gocke E, Hayashi M, Lovell DP, Lutz WK, Marzin D, Moore M, Nohmi T, Phillips DH, Van Benthem J. Thybaud V, et al. Mutat Res. 2011 Aug 16;723(2):121-8. doi: 10.1016/j.mrgentox.2010.09.002. Epub 2010 Sep 17. Mutat Res. 2011. PMID: 20854927
Compilation and use of genetic toxicity historical control data.
Hayashi M, Dearfield K, Kasper P, Lovell D, Martus HJ, Thybaud V. Hayashi M, et al. Among authors: thybaud v. Mutat Res. 2011 Aug 16;723(2):87-90. doi: 10.1016/j.mrgentox.2010.09.007. Epub 2010 Oct 8. Mutat Res. 2011. PMID: 20933606
Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity? I. Reports of individual databases presented at an EURL ECVAM Workshop.
Kirkland D, Zeiger E, Madia F, Gooderham N, Kasper P, Lynch A, Morita T, Ouedraogo G, Parra Morte JM, Pfuhler S, Rogiers V, Schulz M, Thybaud V, van Benthem J, Vanparys P, Worth A, Corvi R. Kirkland D, et al. Among authors: thybaud v. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:55-68. doi: 10.1016/j.mrgentox.2014.10.005. Epub 2014 Oct 23. Mutat Res Genet Toxicol Environ Mutagen. 2014. PMID: 25435356 Free article.
Strategy for genotoxicity testing: hazard identification and risk assessment in relation to in vitro testing.
Thybaud V, Aardema M, Clements J, Dearfield K, Galloway S, Hayashi M, Jacobson-Kram D, Kirkland D, MacGregor JT, Marzin D, Ohyama W, Schuler M, Suzuki H, Zeiger E; Expert Working Group on Hazard Identification and Risk Assessment in Relation to In Vitro Testing. Thybaud V, et al. Mutat Res. 2007 Feb 3;627(1):41-58. doi: 10.1016/j.mrgentox.2006.10.003. Epub 2006 Nov 27. Mutat Res. 2007. PMID: 17126066
Relationships between p53 status, apoptosis and induction of micronuclei in different human and mouse cell lines in vitro: Implications for improving existing assays.
Whitwell J, Smith R, Jenner K, Lyon H, Wood D, Clements J, Aschcroft-Hawley K, Gollapudi B, Kirkland D, Lorge E, Pfuhler S, Tanir JY, Thybaud V. Whitwell J, et al. Among authors: thybaud v. Mutat Res Genet Toxicol Environ Mutagen. 2015 Aug;789-790:7-27. doi: 10.1016/j.mrgentox.2015.05.011. Epub 2015 May 30. Mutat Res Genet Toxicol Environ Mutagen. 2015. PMID: 26232254
Standardized cell sources and recommendations for good cell culture practices in genotoxicity testing.
Lorge E, Moore MM, Clements J, O'Donovan M, Fellows MD, Honma M, Kohara A, Galloway S, Armstrong MJ, Thybaud V, Gollapudi B, Aardema MJ, Tanir JY. Lorge E, et al. Among authors: thybaud v. Mutat Res Genet Toxicol Environ Mutagen. 2016 Oct;809:1-15. doi: 10.1016/j.mrgentox.2016.08.001. Epub 2016 Aug 3. Mutat Res Genet Toxicol Environ Mutagen. 2016. PMID: 27692294 Free article.
61 results