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Showing results for thymus doerfler
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Caspase enzyme activity is not essential for apoptosis during thymocyte development.
Doerfler P, Forbush KA, Perlmutter RM. Doerfler P, et al. J Immunol. 2000 Apr 15;164(8):4071-9. doi: 10.4049/jimmunol.164.8.4071. J Immunol. 2000. PMID: 10754300
To address the importance of caspases in thymocyte development, we have generated transgenic mice that express the baculovirus protein p35, a viral caspase inhibitor, specifically in the thymus. p35 expression inhibited Fas (CD95)-, CD3-, or peptide-induced caspase activit …
To address the importance of caspases in thymocyte development, we have generated transgenic mice that express the baculovirus protein p35, …