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Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current.
Beca S, Helli PB, Simpson JA, Zhao D, Farman GP, Jones P, Tian X, Wilson LS, Ahmad F, Chen SRW, Movsesian MA, Manganiello V, Maurice DH, Conti M, Backx PH. Beca S, et al. Among authors: tian x. Circ Res. 2011 Oct 14;109(9):1024-1030. doi: 10.1161/CIRCRESAHA.111.250464. Epub 2011 Sep 8. Circ Res. 2011. PMID: 21903937 Free PMC article.
Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias.
Xiao J, Tian X, Jones PP, Bolstad J, Kong H, Wang R, Zhang L, Duff HJ, Gillis AM, Fleischer S, Kotlikoff M, Copello JA, Chen SR. Xiao J, et al. Among authors: tian x. J Biol Chem. 2007 Nov 30;282(48):34828-38. doi: 10.1074/jbc.M707423200. Epub 2007 Oct 5. J Biol Chem. 2007. PMID: 17921453 Free PMC article.
Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release.
Zhou Q, Xiao J, Jiang D, Wang R, Vembaiyan K, Wang A, Smith CD, Xie C, Chen W, Zhang J, Tian X, Jones PP, Zhong X, Guo A, Chen H, Zhang L, Zhu W, Yang D, Li X, Chen J, Gillis AM, Duff HJ, Cheng H, Feldman AM, Song LS, Fill M, Back TG, Chen SR. Zhou Q, et al. Among authors: tian x. Nat Med. 2011 Jul 10;17(8):1003-9. doi: 10.1038/nm.2406. Nat Med. 2011. PMID: 21743453 Free PMC article.
The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias.
Chen W, Wang R, Chen B, Zhong X, Kong H, Bai Y, Zhou Q, Xie C, Zhang J, Guo A, Tian X, Jones PP, O'Mara ML, Liu Y, Mi T, Zhang L, Bolstad J, Semeniuk L, Cheng H, Zhang J, Chen J, Tieleman DP, Gillis AM, Duff HJ, Fill M, Song LS, Chen SR. Chen W, et al. Among authors: tian x. Nat Med. 2014 Feb;20(2):184-92. doi: 10.1038/nm.3440. Epub 2014 Jan 19. Nat Med. 2014. PMID: 24441828 Free PMC article.
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