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30 results
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Molecular mechanism of cAMP modulation of HCN pacemaker channels.
Wainger BJ, DeGennaro M, Santoro B, Siegelbaum SA, Tibbs GR. Wainger BJ, et al. Among authors: tibbs gr. Nature. 2001 Jun 14;411(6839):805-10. doi: 10.1038/35081088. Nature. 2001. PMID: 11459060
HCN and K2P Channels in Anesthetic Mechanisms Research.
Riegelhaupt PM, Tibbs GR, Goldstein PA. Riegelhaupt PM, et al. Among authors: tibbs gr. Methods Enzymol. 2018;602:391-416. doi: 10.1016/bs.mie.2018.01.015. Epub 2018 Mar 2. Methods Enzymol. 2018. PMID: 29588040 Review.
Voltage-Gated Ion Channels in the PNS: Novel Therapies for Neuropathic Pain?
Tibbs GR, Posson DJ, Goldstein PA. Tibbs GR, et al. Trends Pharmacol Sci. 2016 Jul;37(7):522-542. doi: 10.1016/j.tips.2016.05.002. Epub 2016 May 24. Trends Pharmacol Sci. 2016. PMID: 27233519 Review.
cAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore.
Lyashchenko AK, Redd KJ, Goldstein PA, Tibbs GR. Lyashchenko AK, et al. Among authors: tibbs gr. PLoS One. 2014 Jul 1;9(7):e101236. doi: 10.1371/journal.pone.0101236. eCollection 2014. PLoS One. 2014. PMID: 24983358 Free PMC article.
HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain.
Tibbs GR, Rowley TJ, Sanford RL, Herold KF, Proekt A, Hemmings HC Jr, Andersen OS, Goldstein PA, Flood PD. Tibbs GR, et al. J Pharmacol Exp Ther. 2013 Jun;345(3):363-73. doi: 10.1124/jpet.113.203620. Epub 2013 Apr 2. J Pharmacol Exp Ther. 2013. PMID: 23549867 Free PMC article.
PIP2-mediated HCN3 channel gating is crucial for rhythmic burst firing in thalamic intergeniculate leaflet neurons.
Ying SW, Tibbs GR, Picollo A, Abbas SY, Sanford RL, Accardi A, Hofmann F, Ludwig A, Goldstein PA. Ying SW, et al. Among authors: tibbs gr. J Neurosci. 2011 Jul 13;31(28):10412-23. doi: 10.1523/JNEUROSCI.0021-11.2011. J Neurosci. 2011. PMID: 21753018 Free PMC article.
Voltage-dependent opening of HCN channels: Facilitation or inhibition by the phytoestrogen, genistein, is determined by the activation status of the cyclic nucleotide gating ring.
Rozario AO, Turbendian HK, Fogle KJ, Olivier NB, Tibbs GR. Rozario AO, et al. Among authors: tibbs gr. Biochim Biophys Acta. 2009 Sep;1788(9):1939-49. doi: 10.1016/j.bbamem.2009.06.003. Epub 2009 Jun 11. Biochim Biophys Acta. 2009. PMID: 19524546 Free PMC article.
Probing S4 and S5 segment proximity in mammalian hyperpolarization-activated HCN channels by disulfide bridging and Cd2+ coordination.
Bell DC, Turbendian HK, Valley MT, Zhou L, Riley JH, Siegelbaum SA, Tibbs GR. Bell DC, et al. Among authors: tibbs gr. Pflugers Arch. 2009 Jun;458(2):259-72. doi: 10.1007/s00424-008-0613-3. Epub 2008 Nov 26. Pflugers Arch. 2009. PMID: 19034494 Free PMC article.
Ion binding in the open HCN pacemaker channel pore: fast mechanisms to shape "slow" channels.
Lyashchenko AK, Tibbs GR. Lyashchenko AK, et al. Among authors: tibbs gr. J Gen Physiol. 2008 Mar;131(3):227-43. doi: 10.1085/jgp.200709868. Epub 2008 Feb 11. J Gen Physiol. 2008. PMID: 18270171 Free PMC article.
Propofol inhibits HCN1 pacemaker channels by selective association with the closed states of the membrane embedded channel core.
Lyashchenko AK, Redd KJ, Yang J, Tibbs GR. Lyashchenko AK, et al. Among authors: tibbs gr. J Physiol. 2007 Aug 15;583(Pt 1):37-56. doi: 10.1113/jphysiol.2007.136465. Epub 2007 Jun 14. J Physiol. 2007. PMID: 17569731 Free PMC article.
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