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Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics.
Bateman RL, Ashworth J, Witte JF, Baker LJ, Bhanumoorthy P, Timm DE, Hurley TD, Grompe M, McClard RW. Bateman RL, et al. Biochem J. 2007 Mar 1;402(2):251-60. doi: 10.1042/BJ20060961. Biochem J. 2007. PMID: 17064256 Free PMC article.
Previously, we prepared a partial mimic of the putative tetrahedral intermediate in the reaction catalysed by FAH co-crystallized with the enzyme to reveal details of the mechanism [Bateman, Bhanumoorthy, Witte, McClard, Grompe and Timm (2001) J. Biol. Chem. 276, 15284-152 …
Previously, we prepared a partial mimic of the putative tetrahedral intermediate in the reaction catalysed by FAH co-crystallized with the e …
Hippocampal AMPA and NMDA mRNA levels and subunit immunoreactivity in human temporal lobe epilepsy patients and a rodent model of chronic mesial limbic epilepsy.
Mathern GW, Pretorius JK, Leite JP, Kornblum HI, Mendoza D, Lozada A, Bertram EH 3rd. Mathern GW, et al. Epilepsy Res. 1998 Sep;32(1-2):154-71. doi: 10.1016/s0920-1211(98)00048-5. Epilepsy Res. 1998. PMID: 9761317
Similarly, spontaneously seizing rats after SSLSE, kindled rats, and control animals were studied for: fascia dentata neuron densities: GluR1 and NMDAR2(a&b) IR; and neo-Timm's staining. In HS and non-HS cases, the mRNA hybridization densities per granule cell, as well …
Similarly, spontaneously seizing rats after SSLSE, kindled rats, and control animals were studied for: fascia dentata neuron densities: GluR …
Aberrant hippocampal mossy fiber sprouting correlates with greater NMDAR2 receptor staining.
Mathern GW, Leite JP, Babb TL, Pretorius JK, Kuhlman PA, Mendoza D, Fried I, Sakamoto AC, Assirati JA, Adelson PD, Peacock WJ. Mathern GW, et al. Neuroreport. 1996 Apr 10;7(5):1029-35. doi: 10.1097/00001756-199604100-00015. Neuroreport. 1996. PMID: 8804045
Patients with hippocampal sclerosis (n = 11) were compared with those with temporal mass lesions (n = 7) and material obtained at autopsies (n = 4); and unilateral KA-injected rat hippocampi (n = 7) were compared with the contralateral saline-injected side and non-lesioned animal …
Patients with hippocampal sclerosis (n = 11) were compared with those with temporal mass lesions (n = 7) and material obtained at autopsies …
Seizures decrease postnatal neurogenesis and granule cell development in the human fascia dentata.
Mathern GW, Leiphart JL, De Vera A, Adelson PD, Seki T, Neder L, Leite JP. Mathern GW, et al. Epilepsia. 2002;43 Suppl 5:68-73. doi: 10.1046/j.1528-1157.43.s.5.28.x. Epilepsia. 2002. PMID: 12121298 Free article.
METHODS: Surgically resected (n = 53) and age-comparable autopsy (n = 22) hippocampi were studied for neuronal densities, polysialic acid (PSA) neural cell adhesion molecule (NCAM) immunoreactivity (IR), TUNEL, and neo-Timm's histochemistry. RESULTS: Compared with autopsy …
METHODS: Surgically resected (n = 53) and age-comparable autopsy (n = 22) hippocampi were studied for neuronal densities, polysialic acid (P …
Anoxia during kainate status epilepticus shortens behavioral convulsions but generates hippocampal neuron loss and supragranular mossy fiber sprouting.
Mathern GW, Price G, Rosales C, Pretorius JK, Lozada A, Mendoza D. Mathern GW, et al. Epilepsy Res. 1998 Apr;30(2):133-51. doi: 10.1016/s0920-1211(97)00103-4. Epilepsy Res. 1998. PMID: 9600545
Hippocampal sections showed that compared to controls: (1) hypoxia-only rats showed no differences in ventral neuron densities and neo-Timm's stained IML-OML GVs; (2) KA-status rats had decreased CA3 densities and a non-significant increase in ventral IML-OML GV difference …
Hippocampal sections showed that compared to controls: (1) hypoxia-only rats showed no differences in ventral neuron densities and neo-Ti …