TLR8 aggravates skin inflammation and fibrosis by activating skin fibroblasts in systemic sclerosis.
Kong X, Jiang S, He Q, Shi X, Pu W, Huang Y, Ma Y, Liu Q, Sun D, Huang D, Wu F, Li P, Tu W, Zhao Y, Wang L, Chen Y, Wu W, Tang Y, Zhao X, Zhu Q, Gao J, Xu W, Shui X, Qian F, Wang J.
Kong X, et al.
Rheumatology (Oxford). 2023 Sep 4:kead456. doi: 10.1093/rheumatology/kead456. Online ahead of print.
Rheumatology (Oxford). 2023.
PMID: 37665747
The role of TLR8 in inflammation and fibrosis was investigated using a TLR8-overexpression vector, activator (VTX-2337), inhibitor (cu-cpt-8m), and TLR8 siRNA in skin fibroblasts. ...Consistently, both TLR8-siRNA and cu-cpt-8m reversed the phenotypes o …
The role of TLR8 in inflammation and fibrosis was investigated using a TLR8-overexpression vector, activator (VTX-2337), inhib …