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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 2
2001 1
2002 3
2003 6
2004 12
2005 27
2006 49
2007 62
2008 49
2009 73
2010 74
2011 88
2012 84
2013 98
2014 102
2015 117
2016 103
2017 105
2018 107
2019 93
2020 141
2021 137
2022 117
2023 127
2024 42

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1,604 results

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Page 1
The Relevance of TLR8 in Viral Infections.
Martínez-Espinoza I, Guerrero-Plata A. Martínez-Espinoza I, et al. Pathogens. 2022 Jan 22;11(2):134. doi: 10.3390/pathogens11020134. Pathogens. 2022. PMID: 35215078 Free PMC article. Review.
Toll-like receptors (TLRs) are the largest pattern recognition receptors responsible for activating the innate and adaptive immune response against viruses through the release of inflammatory cytokines and antiviral mediators. Viruses are recognized by several TLRs, including …
Toll-like receptors (TLRs) are the largest pattern recognition receptors responsible for activating the innate and adaptive immune response …
TLR8 gain of function: a tall surprise.
Boisson B, Casanova JL. Boisson B, et al. Blood. 2021 May 6;137(18):2420-2422. doi: 10.1182/blood.2020010463. Blood. 2021. PMID: 33956066 Free article. No abstract available.
TLR8 reprograms human Treg metabolism and function.
Liu X, Li L, Peng G. Liu X, et al. Aging (Albany NY). 2019 Sep 4;11(17):6614-6615. doi: 10.18632/aging.102223. Epub 2019 Sep 4. Aging (Albany NY). 2019. PMID: 31487689 Free PMC article. No abstract available.
CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes.
Yang C, Bachu M, Du Y, Brauner C, Yuan R, Ah Kioon MD, Chesi G, Barrat FJ, Ivashkiv LB. Yang C, et al. Nat Commun. 2022 Jun 14;13(1):3426. doi: 10.1038/s41467-022-31132-7. Nat Commun. 2022. PMID: 35701499 Free PMC article.
Mechanistically, costimulation by CXCL4 and TLR8 synergistically activates TBK1 and IKKepsilon, repurposes these kinases towards an inflammatory response via coupling with IRF5, and activates the NLRP3 inflammasome. CXCL4 signaling, in a cooperative and synergistic manner …
Mechanistically, costimulation by CXCL4 and TLR8 synergistically activates TBK1 and IKKepsilon, repurposes these kinases towards an i …
TLR8: the forgotten relative revindicated.
Cervantes JL, Weinerman B, Basole C, Salazar JC. Cervantes JL, et al. Cell Mol Immunol. 2012 Nov;9(6):434-8. doi: 10.1038/cmi.2012.38. Epub 2012 Oct 22. Cell Mol Immunol. 2012. PMID: 23085951 Free PMC article. Review.
The endosomal Toll-like receptors (TLRs) TLR3, TLR7, TLR8 and TLR9 are important in sensing foreign nucleic acids encountered by phagocytes. Because TLR8 was initially thought to be non-functional in mice, less is known about TLR8 than the genetically and fun …
The endosomal Toll-like receptors (TLRs) TLR3, TLR7, TLR8 and TLR9 are important in sensing foreign nucleic acids encountered by phag …
Trial Watch: experimental TLR7/TLR8 agonists for oncological indications.
Frega G, Wu Q, Le Naour J, Vacchelli E, Galluzzi L, Kroemer G, Kepp O. Frega G, et al. Oncoimmunology. 2020 Jul 21;9(1):1796002. doi: 10.1080/2162402X.2020.1796002. Oncoimmunology. 2020. PMID: 32934889 Free PMC article. Review.
Both resiquimod and motolimod operate as agonists of Toll-like receptor 7 (TLR7) and/or TLR8, in thus far delivering adjuvant-like signals to antigen-presenting cells (APCs). ...Here, we summarize preclinical and clinical evidence recently collected to support the developm …
Both resiquimod and motolimod operate as agonists of Toll-like receptor 7 (TLR7) and/or TLR8, in thus far delivering adjuvant-like si …
TLR8 aggravates skin inflammation and fibrosis by activating skin fibroblasts in systemic sclerosis.
Kong X, Jiang S, He Q, Shi X, Pu W, Huang Y, Ma Y, Liu Q, Sun D, Huang D, Wu F, Li P, Tu W, Zhao Y, Wang L, Chen Y, Wu W, Tang Y, Zhao X, Zhu Q, Gao J, Xu W, Shui X, Qian F, Wang J. Kong X, et al. Rheumatology (Oxford). 2023 Sep 4:kead456. doi: 10.1093/rheumatology/kead456. Online ahead of print. Rheumatology (Oxford). 2023. PMID: 37665747
The role of TLR8 in inflammation and fibrosis was investigated using a TLR8-overexpression vector, activator (VTX-2337), inhibitor (cu-cpt-8m), and TLR8 siRNA in skin fibroblasts. ...Consistently, both TLR8-siRNA and cu-cpt-8m reversed the phenotypes o …
The role of TLR8 in inflammation and fibrosis was investigated using a TLR8-overexpression vector, activator (VTX-2337), inhib …
Human toll-like receptor 8 (TLR8) in NK cells: Implication for cancer immunotherapy.
Veneziani I, Alicata C, Moretta L, Maggi E. Veneziani I, et al. Immunol Lett. 2023 Sep;261:13-16. doi: 10.1016/j.imlet.2023.07.003. Epub 2023 Jul 13. Immunol Lett. 2023. PMID: 37451320 Free article. Review.
In particular CD56(bright) NK cells subset, that is the most abundant NK cell subset in tissues and tumor microenvironment (TME), was mostly activated in terms of pro-inflammatory cytokine production, proliferation and cytotoxicity, by agonists specific for endosomal TLR8. …
In particular CD56(bright) NK cells subset, that is the most abundant NK cell subset in tissues and tumor microenvironment (TME), was mostly …
TLR8 escapes X chromosome inactivation in human monocytes and CD4(+) T cells.
Youness A, Cenac C, Faz-López B, Grunenwald S, Barrat FJ, Chaumeil J, Mejía JE, Guéry JC. Youness A, et al. Biol Sex Differ. 2023 Sep 18;14(1):60. doi: 10.1186/s13293-023-00544-5. Biol Sex Differ. 2023. PMID: 37723501 Free PMC article.
CONCLUSIONS: TLR8, mirroring TLR7, escapes XCI in human monocytes and CD4(+) T cells. ...Surprisingly, these differences were attributable not only to the ability of TLR7 and TLR8 to be expressed on the Xi, but also to the joint transcriptional behavior of the TLR7- …
CONCLUSIONS: TLR8, mirroring TLR7, escapes XCI in human monocytes and CD4(+) T cells. ...Surprisingly, these differences were attribu …
Targeting the innate immune receptor TLR8 using small-molecule agents.
Sakaniwa K, Shimizu T. Sakaniwa K, et al. Acta Crystallogr D Struct Biol. 2020 Jul 1;76(Pt 7):621-629. doi: 10.1107/S2059798320006518. Epub 2020 Jun 17. Acta Crystallogr D Struct Biol. 2020. PMID: 32627735 Free PMC article. Review.
Toll-like receptors (TLRs) are pattern-recognition receptors that initiate innate immune responses. Among the TLRs, TLR8 (and TLR7) recognizes single-stranded RNA to mediate downstream signals. In recent years, intensive X-ray crystal structural analyses have provided atom …
Toll-like receptors (TLRs) are pattern-recognition receptors that initiate innate immune responses. Among the TLRs, TLR8 (and TLR7) r …
1,604 results