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Structural and thermodynamic analyses of human TMED1 (p24gamma1) Golgi dynamics.
Mota DCAM, Cardoso IA, Mori RM, Batista MRB, Basso LGM, Nonato MC, Costa-Filho AJ, Mendes LFS. Mota DCAM, et al. Biochimie. 2022 Jan;192:72-82. doi: 10.1016/j.biochi.2021.10.002. Epub 2021 Oct 9. Biochimie. 2022. PMID: 34634369
Besides, although the presence of a TMED homo-oligomerization was suggested previously based on crystallographic contacts observed for the isolated Golgi Dynamics (GOLD) domain, no further analyses of its presence in solution were done. Here, we describe the first high-resolution …
Besides, although the presence of a TMED homo-oligomerization was suggested previously based on crystallographic contacts observed for the i …
The GOLD domain-containing protein TMED1 is involved in interleukin-33 signaling.
Connolly DJ, O'Neill LA, McGettrick AF. Connolly DJ, et al. J Biol Chem. 2013 Feb 22;288(8):5616-23. doi: 10.1074/jbc.M112.403899. Epub 2013 Jan 14. J Biol Chem. 2013. PMID: 23319592 Free PMC article.
The detection of IL-33 by ST2L initiates downstream signaling pathways that result in the activation of MAPKs and NF-kappaB. Here, we show that TMED1 associates with ST2L. Using a series of mutation and deletion constructs, we demonstrate that this interaction is mediated …
The detection of IL-33 by ST2L initiates downstream signaling pathways that result in the activation of MAPKs and NF-kappaB. Here, we show t …
TMED family genes and their roles in human diseases.
Zhou L, Li H, Yao H, Dai X, Gao P, Cheng H. Zhou L, et al. Int J Med Sci. 2023 Oct 16;20(13):1732-1743. doi: 10.7150/ijms.87272. eCollection 2023. Int J Med Sci. 2023. PMID: 37928880 Free PMC article. Review.
The members of the transmembrane emp24 domain-containing protein (TMED) family are summarized in human as four subfamilies, alpha (TMED 4, 9), beta (TMED 2), gamma (TMED1, 3, 5, 6, 7) and delta (TMED 10), with a total of nine members, which are important regulators of intr …
The members of the transmembrane emp24 domain-containing protein (TMED) family are summarized in human as four subfamilies, alpha (TMED 4, 9 …
Integrative Multi-Omics Analysis Identifies Transmembrane p24 Trafficking Protein 1 (TMED1) as a Potential Prognostic Marker in Colorectal Cancer.
Guo X, Zhou W, Jin J, Lin J, Zhang W, Zhang L, Luan X. Guo X, et al. Biology (Basel). 2024 Jan 29;13(2):83. doi: 10.3390/biology13020083. Biology (Basel). 2024. PMID: 38392302 Free PMC article.
However, the expression level and biological role of TMED1 in colorectal cancer (CRC) have yet to be fully elucidated. In this study, the integration of patient survival and multi-omics data (immunohistochemical staining, transcriptomics, and proteomics) revealed that the …
However, the expression level and biological role of TMED1 in colorectal cancer (CRC) have yet to be fully elucidated. In this study, …
Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling.
Fenech EJ, Lari F, Charles PD, Fischer R, Laétitia-Thézénas M, Bagola K, Paton AW, Paton JC, Gyrd-Hansen M, Kessler BM, Christianson JC. Fenech EJ, et al. Elife. 2020 Jul 2;9:e57306. doi: 10.7554/eLife.57306. Elife. 2020. PMID: 32614325 Free PMC article.
Among these were four membrane-embedded interactors of RNF26, a polytopic E3 whose abundance is auto-regulated by ubiquitin-proteasome dependent degradation. RNF26 co-assembles with TMEM43, ENDOD1, TMEM33 and TMED1 to form a complex capable of modulating innate immune sign …
Among these were four membrane-embedded interactors of RNF26, a polytopic E3 whose abundance is auto-regulated by ubiquitin-proteasome depen …
TMED2/9/10 Serve as Biomarkers for Poor Prognosis in Head and Neck Squamous Carcinoma.
Gao W, Zhang ZW, Wang HY, Li XD, Peng WT, Guan HY, Liao YX, Liu A. Gao W, et al. Front Genet. 2022 Jun 8;13:895281. doi: 10.3389/fgene.2022.895281. eCollection 2022. Front Genet. 2022. PMID: 35754792 Free PMC article.
Results: Compared with normal tissues, the mRNA expression levels of TMED1/2/4/5/7/8/9/10 were significantly increased in the TCGA HNSC dataset. ...
Results: Compared with normal tissues, the mRNA expression levels of TMED1/2/4/5/7/8/9/10 were significantly increased in the TCGA HN …
Comparative proteomic analysis of PK15 swine kidney cells infected with a pseudorabies pathogenic variant and the Bartha-K/61 vaccine strain.
Zhang H, Zhang R, Wang F, Li G, Wen Y, Shan H. Zhang H, et al. Microb Pathog. 2022 Sep;170:105698. doi: 10.1016/j.micpath.2022.105698. Epub 2022 Aug 5. Microb Pathog. 2022. PMID: 35934202
Compared to Bartha-K/61-infected PK15 cells, SD-2017-infected cells displayed differentially expressed proteins involved in tryptophan metabolism, mitophagy and Notch signaling. Western blot analysis of MARK2, TSR1 and TMED1 three representative proteins validated the reli …
Compared to Bartha-K/61-infected PK15 cells, SD-2017-infected cells displayed differentially expressed proteins involved in tryptophan metab …
Downregulation of Three Novel miRNAs in the Lymph Nodes of Sheep Immunized With the Brucella suis Strain 2 Vaccine.
Chen S, Wang C, Chen Q, Zhao D, Liu Y, Zhao S, Fu S, He X, Yang B, Zhao Q, An Q, Zhang Z, Cheng Y, Man C, Liu G, Wei X, Zhang W, Du L, Wang F. Chen S, et al. Front Vet Sci. 2022 Feb 22;9:813170. doi: 10.3389/fvets.2022.813170. eCollection 2022. Front Vet Sci. 2022. PMID: 35274021 Free PMC article.
The immune-related target genes of novel_229 included ENSOARG00000000649 and TMED1, as well as LCN2, PDPK1 and LPO were novel_609 target genes. ...
The immune-related target genes of novel_229 included ENSOARG00000000649 and TMED1, as well as LCN2, PDPK1 and LPO were novel_609 tar …
Identification and Analysis of ZIC-Related Genes in Cerebellum of Autism Spectrum Disorders.
Li H, Cui J, Hu C, Li H, Luo X, Hao Y. Li H, et al. Neuropsychiatr Dis Treat. 2024 Feb 22;20:325-339. doi: 10.2147/NDT.S444138. eCollection 2024. Neuropsychiatr Dis Treat. 2024. PMID: 38410689 Free PMC article.
RESULTS: (i) ZIC1, ZIC2, and ZIC3 were associated with neurodevelopmental disorders and risk genes related to ASD in the human cerebellum and (ii) ZIC1, ZIC2, and ZIC3 were highly expressed in the cerebellum, which may play a pathogenic role by affecting neuronal development and …
RESULTS: (i) ZIC1, ZIC2, and ZIC3 were associated with neurodevelopmental disorders and risk genes related to ASD in the human cerebellum an …
11 results