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TMEM74 promotes tumor cell survival by inducing autophagy via interactions with ATG16L1 and ATG9A.
Sun Y, Chen Y, Zhang J, Cao L, He M, Liu X, Zhao N, Yin A, Huang H, Wang L. Sun Y, et al. Cell Death Dis. 2017 Aug 31;8(8):e3031. doi: 10.1038/cddis.2017.370. Cell Death Dis. 2017. PMID: 29048433 Free PMC article.
Autophagy is a highly inducible system of intracellular degradation that occurs in lysosomes or vacuoles. Transmembrane 74 (TMEM74) has been shown to induce autophagy. However, the mechanism by which TMEM74 stimulates autophagy and the impacts of TMEM74-induc …
Autophagy is a highly inducible system of intracellular degradation that occurs in lysosomes or vacuoles. Transmembrane 74 (TMEM74) h …
Functional coupling of Tmem74 and HCN1 channels regulates anxiety-like behavior in BLA neurons.
Shao LX, Jiang Q, Liu XX, Gong DM, Yin YX, Wu G, Sun NH, Wang CK, Chen QZ, Yu C, Shi WX, Fan HY, Fukunaga K, Chen Z, Lu YM, Han F. Shao LX, et al. Mol Psychiatry. 2019 Oct;24(10):1461-1477. doi: 10.1038/s41380-019-0402-8. Epub 2019 Mar 18. Mol Psychiatry. 2019. PMID: 30886335
Furthermore, genetic deletion of Tmem74 or selective knockdown of Tmem74 in BLA pyramidal neurons resulted in anxiety-like behaviors in mice. ...The I(h) current blocker ZD7288 mimicked these effects in BLA pyramidal neurons in wild-type mice but not in Tmem74 …
Furthermore, genetic deletion of Tmem74 or selective knockdown of Tmem74 in BLA pyramidal neurons resulted in anxiety-like beh …
The Expression of TMEM74 in Liver Cancer and Lung Cancer Correlating With Survival Outcomes.
Sun Y, Deng J, Xia P, Chen W, Wang L. Sun Y, et al. Appl Immunohistochem Mol Morphol. 2019 Sep;27(8):618-625. doi: 10.1097/PAI.0000000000000659. Appl Immunohistochem Mol Morphol. 2019. PMID: 29629952
Meanwhile, further analysis showed that the levels of TMEM74 expression were closely correlated to survival period of patients-the higher expression of TMEM74 was correlated with shorter survival period. Moreover, the in vitro experiments showed that overexpression …
Meanwhile, further analysis showed that the levels of TMEM74 expression were closely correlated to survival period of patients-the hi …
Autophagy regulatory molecule, TMEM74, interacts with BIK and inhibits BIK-induced apoptosis.
Sun Y, Li Q, Zhang J, Chen Z, He Q, Liu X, Zhao N, Yin A, Huang H, He M, Cao L, Wang L. Sun Y, et al. Cell Signal. 2017 Aug;36:34-41. doi: 10.1016/j.cellsig.2017.04.005. Epub 2017 Apr 13. Cell Signal. 2017. PMID: 28412412
TMEM74 (Transmembrane protein 74), a lysosome transmembrane protein, induces cell autophagy. ...The data indicated that TMEM74 associates with BIK via TM domains of TMEM74 and BH3 domain of BIK. ...
TMEM74 (Transmembrane protein 74), a lysosome transmembrane protein, induces cell autophagy. ...The data indicated that TMEM74 …
TMEM74, a lysosome and autophagosome protein, regulates autophagy.
Yu C, Wang L, Lv B, Lu Y, Zeng L, Chen Y, Ma D, Shi T, Wang L. Yu C, et al. Biochem Biophys Res Commun. 2008 May 2;369(2):622-9. doi: 10.1016/j.bbrc.2008.02.055. Epub 2008 Feb 21. Biochem Biophys Res Commun. 2008. PMID: 18294959
Subcellular localization analysis showed TMEM74 localized to the lysosome and autophagosome. Overexpression of TMEM74 in HeLa cells resulted in autophagic vacuolization, increased the dotted distribution of MDC and GFP-LC3, and endogenous LC3-II levels. ...These fin …
Subcellular localization analysis showed TMEM74 localized to the lysosome and autophagosome. Overexpression of TMEM74 in HeLa …
Divergent projections of the prelimbic cortex mediate autism- and anxiety-like behaviors.
Luo YF, Lu L, Song HY, Xu H, Zheng ZW, Wu ZY, Jiang CC, Tong C, Yuan HY, Liu XX, Chen X, Sun ML, Tang YM, Fan HY, Han F, Lu YM. Luo YF, et al. Mol Psychiatry. 2023 Jun;28(6):2343-2354. doi: 10.1038/s41380-023-01954-y. Epub 2023 Jan 23. Mol Psychiatry. 2023. PMID: 36690791 Free PMC article.
The comorbidity of autism spectrum disorder and anxiety is common, but the underlying circuitry is poorly understood. Here, Tmem74(-/-) mice showed autism- and anxiety-like behaviors along with increased excitability of pyramidal neurons (PNs) in the prelimbic cortex (PL), …
The comorbidity of autism spectrum disorder and anxiety is common, but the underlying circuitry is poorly understood. Here, Tmem74(-/ …
Prognosis-related autophagy genes in female lung adenocarcinoma.
Liu Z, Zhang K, Zhao Z, Qin Z, Tang H. Liu Z, et al. Medicine (Baltimore). 2022 Jan 7;101(1):e28500. doi: 10.1097/MD.0000000000028500. Medicine (Baltimore). 2022. PMID: 35029906 Free PMC article.
Up-regulated 15 genes: PARP1, BNIP3, P4HB, ATIC, IKBKE, ITGB4, VMP1, PTK6, EIF4EBP1, GAPDH, ATG9B, ERO1A, TMEM74, CDKN2A, BIRC5. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis showed that these genes were significantly associated with autophagy and mito …
Up-regulated 15 genes: PARP1, BNIP3, P4HB, ATIC, IKBKE, ITGB4, VMP1, PTK6, EIF4EBP1, GAPDH, ATG9B, ERO1A, TMEM74, CDKN2A, BIRC5. Gene …
Super-variants identification for brain connectivity.
Li T, Hu J, Wang S, Zhang H. Li T, et al. Hum Brain Mapp. 2021 Apr 1;42(5):1304-1312. doi: 10.1002/hbm.25294. Epub 2020 Nov 24. Hum Brain Mapp. 2021. PMID: 33236465 Free PMC article.
These verified super-variants contain single nucleotide polymorphisms that locate in 14 genes which have been reported to have association with brain structure and function, and/or neurodevelopmental and neurodegenerative disorders in the literature. We also identified novel loci …
These verified super-variants contain single nucleotide polymorphisms that locate in 14 genes which have been reported to have association w …
The transmembrane proteins (TMEM) and their role in cell proliferation, migration, invasion, and epithelial-mesenchymal transition in cancer.
Herrera-Quiterio GA, Encarnación-Guevara S. Herrera-Quiterio GA, et al. Front Oncol. 2023 Oct 23;13:1244740. doi: 10.3389/fonc.2023.1244740. eCollection 2023. Front Oncol. 2023. PMID: 37936608 Free PMC article. Review.
TMEM proteins carry out a wide variety of functions necessary to maintain cell homeostasis TMEM165 participates in glycosylation protein, TMEM88 in the development of cardiomyocytes, TMEM45A in epidermal keratinization, and TMEM74 regulating autophagy. However, for many TM …
TMEM proteins carry out a wide variety of functions necessary to maintain cell homeostasis TMEM165 participates in glycosylation protein, TM …
Construction and Validation of a Prognostic Risk Model for Triple-Negative Breast Cancer Based on Autophagy-Related Genes.
Yan C, Liu Q, Jia R. Yan C, et al. Front Oncol. 2022 Feb 4;12:829045. doi: 10.3389/fonc.2022.829045. eCollection 2022. Front Oncol. 2022. PMID: 35186763 Free PMC article.
RESULTS: There are 43 DE-ARGs identified between normal and tumor samples. A risk model for OS using CDKN1A, CTSD, CTSL, EIF4EBP1, TMEM74, and VAMP3 was established based on univariate Cox regression and LASSO regression analysis. ...CONCLUSION: Based on six ARGs (CDKN1A, …
RESULTS: There are 43 DE-ARGs identified between normal and tumor samples. A risk model for OS using CDKN1A, CTSD, CTSL, EIF4EBP1, TMEM74 …
24 results