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TMPRSS12 Functions in Meiosis and Spermiogenesis and Is Required for Male Fertility in Mice.
Zhang J, Zhou X, Wan D, Yu L, Chen X, Yan T, Wu Z, Zheng M, Zhu F, Zhu H. Zhang J, et al. Front Cell Dev Biol. 2022 Apr 25;10:757042. doi: 10.3389/fcell.2022.757042. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35547804 Free PMC article.
Mice deficient in Tmprss12 exhibited male sterility. In meiosis, TMPRSS12 was demonstrated to regulate synapsis and double-strand break repair; spermatocytes of Tmprss12 (-/-) mice underwent impaired meiosis and subsequent apoptosis, resulting in reduced sper …
Mice deficient in Tmprss12 exhibited male sterility. In meiosis, TMPRSS12 was demonstrated to regulate synapsis and double-str …
Tmprss12 is required for sperm motility and uterotubal junction migration in mice.
Larasati T, Noda T, Fujihara Y, Shimada K, Tobita T, Yu Z, Matzuk MM, Ikawa M. Larasati T, et al. Biol Reprod. 2020 Aug 4;103(2):254-263. doi: 10.1093/biolre/ioaa060. Biol Reprod. 2020. PMID: 32529245 Free PMC article.
TMPRSS12 was detected in the acrosomal region of spermatozoa by immunostaining. ...Because Tmprss12 is conserved among mammals, including humans, our results may explain some genetic cases of idiopathic male infertility, and TMPRSS12 and its downstream cascad …
TMPRSS12 was detected in the acrosomal region of spermatozoa by immunostaining. ...Because Tmprss12 is conserved among mammals …
TMPRSS12 Is an Activating Protease for Subtype B Avian Metapneumovirus.
Yun B, Zhang Y, Liu Y, Guan X, Wang Y, Qi X, Cui H, Liu C, Zhang Y, Gao H, Gao L, Li K, Gao Y, Wang X. Yun B, et al. J Virol. 2016 Nov 28;90(24):11231-11246. doi: 10.1128/JVI.01567-16. Print 2016 Dec 15. J Virol. 2016. PMID: 27707927 Free PMC article.
Notably, we observed TMPRSS12 mRNA expression in target organs of aMPV/B in chickens. Overall, our results indicate that TMPRSS12 is crucial for aMPV/B F protein proteolysis and aMPV/B infectivity and that TMPRSS12 may serve as a target for novel therapeutics …
Notably, we observed TMPRSS12 mRNA expression in target organs of aMPV/B in chickens. Overall, our results indicate that TMPRSS12 …
COVID-19 and human spermatozoa-Potential risks for infertility and sexual transmission?
Aitken RJ. Aitken RJ. Andrology. 2021 Jan;9(1):48-52. doi: 10.1111/andr.12859. Epub 2020 Aug 5. Andrology. 2021. PMID: 32649023 Free PMC article. Review.
The latter not only provides COVID-19 with a foothold on the sperm surface but may also promote integration, given the additional presence of a range of proteases (TMPRSS2, TMPRSS11B, TMPRSS12, furin) capable of promoting viral fusion. This article reviews the roles played …
The latter not only provides COVID-19 with a foothold on the sperm surface but may also promote integration, given the additional presence o …
Scanning of novel cancer/testis proteins by human testis proteomic analysis.
Liu M, Hu Z, Qi L, Wang J, Zhou T, Guo Y, Zeng Y, Zheng B, Wu Y, Zhang P, Chen X, Tu W, Zhang T, Zhou Q, Jiang M, Guo X, Zhou Z, Sha J. Liu M, et al. Proteomics. 2013 Apr;13(7):1200-10. doi: 10.1002/pmic.201200489. Epub 2013 Mar 6. Proteomics. 2013. PMID: 23436708
Many of the identified human testicular proteins are associated with human infertility, especially human testicular predominantly expressed proteins. We characterized six novel cancer/testis genes (TMPRSS12, TPPP2, PRSS55, DMRT1, PIWIL1, HEMGN), which map to cancer-associa …
Many of the identified human testicular proteins are associated with human infertility, especially human testicular predominantly expressed …
Characterization of a prognostic four‑gene methylation signature associated with radiotherapy for head and neck squamous cell carcinoma.
Ma J, Li R, Wang J. Ma J, et al. Mol Med Rep. 2019 Jul;20(1):622-632. doi: 10.3892/mmr.2019.10294. Epub 2019 May 24. Mol Med Rep. 2019. PMID: 31180552 Free PMC article.
A four-gene methylation signature was determined by the lasso Cox-PH model that consisted of ZNF10, TMPRSS12, ERGIC2, and RNF215. The risk score based on the four-gene signature was able to divide the training or validation set into two risk groups with significantly diffe …
A four-gene methylation signature was determined by the lasso Cox-PH model that consisted of ZNF10, TMPRSS12, ERGIC2, and RNF215. The …